Chiral Thiophosphoramide and Thioamide Ligands in Catalytic Asymmetric Carbon-Carbon Bond-Formation Reactions

Abstract

C a t a l y t i c A s y m m e t r i c C a r b o n -C a r b o n B o n d -F o r m a t i o n R e a c t i o n sAbstract: Metal complexes with organosulfur ligands exist widely in nature. The high polarizability of the electrons on the sulfur atoms is responsible for a variety of structures and the reactivity of metal complexes with sulfur-containing ligands. Organosulfur-containing chiral ligands have various applications in catalytic asymmetric reactions. Our group has been interested in the applications of a series of thiophosphoramide and thioamide ligands in asymmetric carbon-carbon bond-formation reactions. In this account, we describe the synthesis of chiral thiophosphoramide and thioamide ligands and their applications in catalytic asymmetric carbon-carbon bond formation.

Zinc catalyzed, microwave irradiated Sonogashira reaction by Sodium Aluminate (NaAlO2) as a base in water: A Green entente

“…However, recent research has focused on constructing C-C bonds in the absence of one [9][10] or the other metal [11][12][13][14][15][16] or using alternate strategies that achieve the same net aryl-alkyne bond formation [17]. In organic media, aryl iodides are extensively utilized and are generally used at high temperatures [18]. The corresponding halides, particularly chlorides, are less likely to take part unless a stringent forcing environment is provided.…”