Chiral voltammetric sensor for warfarin enantiomers based on carbon black paste electrode modified by 3,4,9,10-perylenetetracarboxylic acid

Zilberg, R. A.; Maistrenko, V. N.; Kabirova, L. R.; Gus’kov, V. Yu.; Dubrovsky, D. I.

doi:10.1016/j.jelechem.2020.113986

Cited by 27 publications

(9 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CD‐CuMOF displays the potential to be: i) a new class of CS, ii) an enzyme mimic for chiral drugs, and iii) excellent material for enantiomer discrimination for biomolecules using not only electrochemical methods but also chemical methods. A novel chiral electrochemical sensor based on a carbon black paste electrode, consisting of graphitized carbon black powder Carboblack C modified by self‐assembled nanoclusters of 3,4,9,10‐perylene tetracarboxylic acid (PTCA) was developed for the selective recognition and determination of warfarin (WA) enantiomers [296]. The chirality of PTCA nanoclusters was provided by the spontaneous formation of a 2‐D space group during self‐assembly by an external induction of PTCA nanoclusters (Figure 5).…”

Section: Chiral Resolution Np Sensing Approachesmentioning

confidence: 99%

See 1 more Smart Citation

Enantioseparation/Recognition based on nano techniques/materials

Tarigh

2023

J of Separation Science

View full text Add to dashboard Cite

Enantiomers show different behaviors in interaction with the chiral environment. Due to their identical chemical structure and their wide application in various industries, such as agriculture, medicine, pesticide, food, and so forth, their separation is of great importance. Today, the term "nano" is frequently encountered in all fields. Technology and measuring devices are moving towards miniaturization, and the usage of nanomaterials in all sectors is expanding substantially. Given that scientists have recently attempted to apply miniaturized techniques known as nano-liquid chromatography/capillary-liquid chromatography, which were originally accomplished in 1988, as well as the widespread usage of nanomaterials for chiral resolution (back in 1989), this comprehensive study was developed. Searching the terms "nano" and "enantiomer separation" on scientific websites such as Scopus, Google Scholar, and Web of Science yields articles that either use miniaturized instruments or apply nanomaterials as chiral selectors with a variety of chemical and electrochemical detection techniques, which are discussed in this article.

show abstract

Section: Chiral Resolution Np Sensing Approachesmentioning

confidence: 99%

“…The recognition of warfarin (WA) enantiomers on carbon black paste electrode (CBPE) modified by PTCA. Reprinted [296]. …”

Section: Chiral Resolution Np Sensing Approachesmentioning

confidence: 99%

Enantioseparation/Recognition based on nano techniques/materials

Tarigh

2023

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17][18][19] It is well known that a chiral modifier is the key component for building an electrode's chiral surface for creating high enantioselectivity (ϑ) for selected analytes. 19 The majority of methods (except for molecular imprinting [20][21][22][23][24][25][26] ) use one or more chiral components [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] as modifiers for building a chiral layer on the electrode surface (Scheme 1). Obviously, the value of enantioselectivity depends on the structure of the modifier, and for any chiral analyte, the corresponding "complementary" modifier exists that provides the best enantioselectivity (Scheme 2).…”

Section: Introductionmentioning

confidence: 99%

“…The majority of methods (except for molecular imprinting 20–26 ) use one or more chiral components 27–44 as modifiers for building a chiral layer on the electrode surface (Scheme 1). Obviously, the value of enantioselectivity depends on the structure of the modifier, and for any chiral analyte, the corresponding “complementary” modifier exists that provides the best enantioselectivity (Scheme 2).…”

Section: Introductionmentioning

confidence: 99%

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

et al. 2022

Self Cite

View full text Add to dashboard Cite

The use of chiral modifiers is among the simplest and most popular strategies for synthesizing enantioselective voltammetric sensors that are applied for the analysis and discrimination of enantiomerical drugs in various media. The type and structure of the chiral modifier are the key factors for the creation of enantioselectivity to a specified analyte. We suggest a novel approach to the prediction of the quality of a chiral modifier for preparing highly enantioselective sensors. The suggested approach is based on the molecular mechanics modeling of the adsorption of analyte enantiomers on chiral modifiers and on the comparison of the corresponding adsorption energies (ΔEads). The efficiency of our approach is demonstrated using the example of cyclodextrins and chiral single‐wall carbon nanotubes as chiral modifiers, and a wide range of chiral analytes. We found that the experimental enantioselectivity (ϑexp) measured using voltammetry linearly correlates with ΔEads. The suggested approach also showed good predictive power in application to enantioselective chromatography, which further validates its general applicability.

show abstract

“…Pada Spektroskopi Raman untuk mengukur warfarin [45]. Metode CBPE dengan dimodifikasi PTCA ini dapat memisahkan senyawa kiral seperti warfarin dan memiliki kelebihan berupa selektivitas yang tinggi.…”

unclassified

Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen

2021

View full text Add to dashboard Cite

Warfarin merupakan obat antikoagulan oral yang digunakan untuk menangani penyakit terkait dengan tromboembolisme. Warfarin memiliki indeks terapi yang sempit serta memiliki kecenderungan berinteraksi dengan obat maupun herba sehingga membutuhkan pemantauan yang cermat pada efek farmakologi yang ditimbulkan. Penentuan pemberian dosis serta pengamatan efek dari interaksi warfarin dengan obat atau herba salah satunya dapat diketahui dengan menganalisis konsentrasi warfarin dalam plasma darah. Artikel ini merupakan kajian pustaka yang bertujuan untuk memberikan tinjauan mengenai metode yang digunakan untuk menganalisis konsentrasi warfarin dalam plasma darah serta teknik preparasi sampelnya. Metode yang digunakan dalam review artikel ini menggunakan penelusuran melalui basis data PubMed®. Hasil yang didapatkan bahwa metode yang umum digunakan untuk determinasi warfarin dalam plasma darah yakni high-performance liquid chromatography (HPLC) serta ultra-HPLC dengan detektor ultraviolet (UV), fluoresensi (FLD), diode array (DAD), maupun spektroskopi massa (MS). Metode lainnya yaitu spektrofotometri UV/Vis dan spektrofotometri fluoresensi serta elektroforesis. Dari metode tersebut, metode HPLC dengan detektor spektroskopi massa paling banyak digunakan untuk menganalisis warfarin serta teknik preparasi sampel yang umum digunakan yakni preparasi sampel yang umum digunakan yakni presipitasi protein menggunakan asetonitril sebagai protein presipitan serta penambahan asam untuk meningkatkan nilai recovery warfarin dari plasma darah

show abstract

Chiral voltammetric sensor for warfarin enantiomers based on carbon black paste electrode modified by 3,4,9,10-perylenetetracarboxylic acid

Cited by 27 publications

References 59 publications

Enantioseparation/Recognition based on nano techniques/materials

Enantioseparation/Recognition based on nano techniques/materials

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen

Contact Info

Product

Resources

About