Chirurgische Rekonstruktionen beim Larynxkarzinom

Arens, Christoph; Schwemmle, C.; Voigt-Zimmermann, Susanne

doi:10.1007/s00106-020-00916-y

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…9 A variety of materials and methods are available for laryngeal defect reconstruction in open surgery, among which autologous materials such as the ribbon myocutaneous flap (RMF), PMF, mucosal flap, thyroid perichondrium flap, and full-thickness skin graft are common, and repair methods with these materials are mature. 10 The anterior cervical strap muscle used for repair consists of sternohyoid and thyrohyoid muscles, which are designed into a muscle flap with complete fascia, that is, the RMF; this flap can be acquired and used to repair most defects and has been widely used in laryngeal cavity repair. 11 Since Conley began to use the cervical myocutaneous flap to repair laryngeal defects following vertical partial laryngectomy in 1961, 12 laryngeal defect repair using the PMF has gradually matured and has become widely applied.…”

Section: Introductionmentioning

confidence: 99%

Application of Platysma Myocutaneous Flap in Surgical Repair after T2‐3 Glottic Carcinoma Resection

Zhu,

Liang,

Liang

et al. 2024

The Laryngoscope

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ObjectiveNumerous methods and materials are available for vertical partial laryngectomy. In this study, the reparative effects of the platysma myocutaneous flap (PMF) and ribbon myocutaneous flap (RMF) on the postoperative voice quality of patients were compared to provide a reference for selecting a method conducive to improving postoperative voice quality.MethodsA retrospective analysis was performed on patients with unilateral T2‐3 glottic carcinoma. Following vertical partial laryngectomy, the defect was repaired with a PMF or simple RMF. Twelve months after surgery, voice quality was assessed according to voice acoustics, aerodynamics, and subjective perceptual evaluation, and glottic morphology was recorded using a laryngeal stroboscopy.ResultsA total of 70 patients were identified, including 54 in the PMF group and 16 in the RMF group. The PMF group was superior to the RMF group in terms of voice quality assessed by voice acoustics, aerodynamics, and subjective perceptual evaluation. In the PMF group, 72.2% of patients performed phonation with their vocal cords, and approximately 27.8% of patients were affected by supraglottic compression. In the RMF group, 81.3% of patients were affected by supraglottic compression. No significant difference was found in the 5‐year survival rate between the two groups.ConclusionFor defect repair following vertical partial laryngectomy, a PMF can allow better postoperative voice quality to be achieved than an RMF because a PMF can provide more tissue (including strap muscle under the flap) for padding, which enables the glottic portion corresponding to the vocal cord to close well.Level of EvidenceLevel 3 Laryngoscope, 2024

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Section: Introductionmentioning

confidence: 99%

Application of Platysma Myocutaneous Flap in Surgical Repair after T2‐3 Glottic Carcinoma Resection

Zhu,

Liang,

Liang

et al. 2024

The Laryngoscope

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“…The tumor has a high tendency to recur [6]. Symptoms typically include hoarseness, impaired vocal function, breathing problems (dyspnoea), dysphagia, and odynophagia [5,7].…”

Section: Introductionmentioning

confidence: 99%

CLINICAL ROLE OF miRNA BIOMARKERS IN LARYNGEAL SQUAMOUS CELL CARCINOMA (LSCC): LITERATURE REVIEW

Rusinowska,

Tybulczuk

2023

J Hear Sci

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IntroductionMalignant transformations may result from gene dysregulation caused by genetic and epigenetic modifications. The use of miRNAs to treat cancer depends on the downregulation or upregulation of the miRNAs responsible for carcinogenesis (proliferation, angiogenesis, invasion, metastasis), providing the opportunity to suppress tumors. The purpose of this review is to list miRNAs identified so far as biomarkers in laryngeal squamous cell carcinoma (LSCC). This listing may help in predicting the evolution of miRNAs and developing anti-miRNAs and miRNA-mimics as anti-cancer therapies.Material and methodsRelevant publications from 2008 to 2022 were retrieved from the PubMed and Google Scholar databases, using the key words miRNA (PubMed – 149,294 results; Google Scholar – 205,000 results), laryngeal squamous cell carcinoma (PubMed – 33,191 results; Google Scholar – 17,900 results), laryngeal squamous cell carcinoma biomarkers (PubMed – 6249 results; Google Scholar – 18,000 results), laryngeal squamous cell carcinoma miRNA (PubMed – 1338 results; Google Scholar – 17,500 results). Eventually 51 papers were selected for review.ResultsWe identified 51 studies which have detected miRNA-based biomarkers for LSCC, and they are broadly reviewed here.ConclusionsThe identified laryngeal squamous cell-specific miRNA biomarkers appear to be promising for the detection, predicted course, and treatment of LSCC.

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