Chitin membrane for wound dressing application – preparation, characterisation and toxicological evaluation

Singh, Rita; Chacharkar, M. P.; Mathur, Adesh Kumar

doi:10.1111/j.1742-481x.2008.00482.x

Cited by 34 publications

(14 citation statements)

References 26 publications

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“…Table 3 shows commercial antibacterial wound dressing materials containing these bioactive materials 61. Recent developments in wound dressing materials and their production methods as well as the ingredients used have been reviewed 62–75…”

Section: Wound Dressings and Their Propertiesmentioning

confidence: 99%

A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages

Zahedi

Rezaeian

Siadat

et al. 2009

Polymers for Advanced Techs

783

633

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Wound dressings have experienced continuous and significant changes since the ancient times. The development starts with the use of natural materials to simply cover the wounds to the materials of the present time that could be specially made to exhibit various extraordinary functions. The modern bandage materials made of electrospun biopolymers contain various active compounds that are beneficial to the healing of wounds. These materials are fibrous in nature, with the size of fibers segments ranging from tens of nanometers to micrometers. With the right choices of biopolymers used for these fibrous materials, they could enhance the healing of wounds significantly compared with the conventional fibrous dressing materials, such as gauze. These bandages could be made such that they contain bioactive ingredients, such as antimicrobial, antibacterial, and antiinflammatory agents, which could be released to the wounds enhancing their healing. In an active wound dressing (AWD), the main purpose is to control the biochemical states of a wound in order to aid its healing process. This review provides an overview of different types of wounds, effective parameters in wound healing and different types of wound dressing materials with a special emphasis paid to those prepared by electrospinning.

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Section: Wound Dressings and Their Propertiesmentioning

confidence: 99%

A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages

Zahedi

Rezaeian

Siadat

et al. 2009

Polymers for Advanced Techs

783

633

View full text Add to dashboard Cite

show abstract

“…Marine-origin materials are frequently proposed for many biomedical applications. As examples, collagen [22], chitin [23] and chitosan [24] were reported as candidates for the development of wound dressings. However, to the best of our knowledge, no report has previously proposed FSP for this biomedical application.…”

Section: Introductionmentioning

confidence: 99%

Fish sarcoplasmic proteins as a high value marine material for wound dressing applications

Vieira

Franco

Fernandes

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Fish sarcoplasmic proteins (FSP) constitute around 25-30% of the total fish muscle protein. As the FSP are water soluble, FSP were isolated from fresh cod (Gadus morhua) by centrifugation. By SDS-PAGE, it was possible to determine the composition of FSP extracts (FSP-E). The FSP-E undergo denaturation at 44.12 ± 2.34° C, as characterized by differential scanning calorimetry thermograms (DSC). The secondary structure of FSP-E is mainly composed by α-helix structure, as determined by circular dichroism. The cytocompatibility of FSP-E, at concentrations ranging from 5 to 20 mg/mL, was investigated. Concentrations lower than 10 mg/mL have no cytotoxicity cultures of fibroblasts over 72 h. Further on, FSP membranes (FSP-M) were produced by spin coating to evaluate its properties. FSP-M shown having uniform surface as analyzed by Scanning Electron Microscopy (SEM). The relative amount of α-helix structures is higher when compared with the FSP-E. The FSP-M have higher temperature stability than the FSP-E, since they presented a denaturation temperature of 58.88 ± 3.36° C, according to the DSC analysis. FSP-M shown distinctive mechanical properties, with a stiffness of 16.57 ± 3.95 MPa and a yield strength of 23.85 ± 5.97 MPa. Human lung fibroblasts cell lines (MRC-5) were cultured in direct contact with FSP-M, demonstrating its cytocompatibility for 48 h. Based on these results, FSP can be considered a potential biomaterial recovered from nature, for wound dressing applications.

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“…21 Macromolecules most exhaustively studied are cellulosic derivatives, with ethylcellulose (EC) being the one with the highest functionality. [28][29][30][31][32][33][34][35] Chitin organogels with common edible lipid material (oils), could also be used as an alternative for solid fat in many food-products or food-related applications. 21, 24 Sanchez and co-workers showed that EC can be used to create organogels and that by changing the molecular weight of the polymer, the mechanical properties of the organogel could be altered.…”

Section: Introductionmentioning

confidence: 99%

Polymer organogelation with chitin and chitin nanocrystals

Nikiforidis

Scholten

2015

RSC Adv.

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In this paper, we show that biodegradable and biocompatible organogels can be formed with chitin as the filler material and triglycerides as the continuous hydrophobic phase. When crude chitin was used, a large degree of aggregation was observed that prevented the formation of stable organogels. Two approaches were used to diminish this degree of aggregation and increase the stability. Either surfactants were used to increase the dispersability of the crude chitin, or the crude chitin was transformed into smaller rodlike nanocrystals by acid hydrolysis. Both approaches led to the formation of stable organogels with storage moduli up to 10 6 Pa for high chitin concentrations (20 wt%). Three different types of surfactants were used, namely phosphatidylcholine, enzymatically modified phosphatidylcholine and sorbitan monostearate (Span 60). The choice of surfactant has a large influence on the gel strength and the temperature sensitivity of the gels. With chitin nanocrystals, in the presence of surfactants, larger gel strengths were observed for lower concentrations (1-10 wt%), indicating more efficient packing of the particles. Gels were stable even after addition of considerable amounts of water up to 25 wt%. The increase in gel strength in the presence of water (storage modulus) was most likely an effect of the water absorption ability of chitin that increased the effective volume fraction of the fillers.

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Chitin membrane for wound dressing application – preparation, characterisation and toxicological evaluation

Cited by 34 publications

References 26 publications

A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages

A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages

Fish sarcoplasmic proteins as a high value marine material for wound dressing applications

Polymer organogelation with chitin and chitin nanocrystals

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