Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive

Xu, Yiwen; Liang, Kai; Ullah, Wajeeh; Ji, Yali; Ma, Jinghong

doi:10.1016/j.carbpol.2018.03.005

Cited by 44 publications

(22 citation statements)

References 46 publications

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“…2b, the test method of tissue adhesion is illustrated in the schematic diagram. First, fresh porcine skin was cleaned as reported 32 and cut into strips of size 35 mm × 10 mm. Then, 100 μl of freshly prepared gelling solution was applied to one piece, and another piece was brought in contact with the first piece to form a contact area of 10 × 10 mm 2 .…”

Section: Characterization Of the Adhesiveness Of The Hydrogelsmentioning

confidence: 99%

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

et al. 2019

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Dual adhesiveness to tissue and implant biomaterials and bioactivity to stimulate tissue regeneration are interesting properties for developing new generations of tissue-repairing hydrogels with potential new clinical applications. In this study, we developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel with adipic acid dihydrazide (ADH)-modified γ-polyglutamic acid (γ-PGA) as the cross-linking agent, in which the BG plays a multifunctional role to endow the hydrogel with both dual-adhesive and bioactive properties. On one hand, the BG could improve the tissue-bonding strength by providing an alkaline microenvironment to stimulate the bond formation between OSA and the amino groups on the surrounding tissues. On the other hand, BG endows the hydrogel with adhesiveness to implantable materials by releasing Ca ions, which might chelate with the carboxyl groups of the hydrogel matrix. In addition, the composite hydrogel showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. This study demonstrates that a multifunctional hydrogel can be designed by utilizing the multifunctional ions released from silicate BG, and the BG/OSA hydrogel shows good potential as an adhesive and bioactive material for woundhealing applications.

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Section: Characterization Of the Adhesiveness Of The Hydrogelsmentioning

confidence: 99%

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

et al. 2019

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“…Chitin nanocrystals, which mainly come from shrimp and crab shells, are natural polysaccharides with histocompatibility and absorbability. Xu et al [76] prepared a nanocomposite adhesive hydrogel by dispersing chitin nanocrystals (ChiNCs) into a DOPA-grafted citrate-based tissue adhesive. They found that ChiNCs were finely dispersed in the hydrogel matrix and endowed the adhesive with extra cross-links to enhance cohesion performance.…”

Section: Types Of Catechol-based Hydrogelsmentioning

confidence: 99%

Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications

et al. 2019

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Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels.

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“…When the dual-crosslinked hydrogels deform, the weaker non-covalent bonds break to dissipate energy as sacrificial bonds, while the covalent bonds are preserved. Incorporation of one type (e.g., hydrogen bonds [22,23,24], hydrophobic associations [25,26], dipole–dipole interactions [27], host-guest complex interactions [28], metal ions chelation [17], and polymer-nanoparticle interfacial bonds [23,29]) or several types (e.g., hydrogen bonds plus hydrophobic associations [30], hydrophobic associations plus ionic interactions [31], hydrogen bonds plus ionic interactions [32], π–π stacking plus hydrogen bonds [33], and hydrogen bonds plus ion-dipole interactions [34,35]) of non-covalent bonds to a covalent network has been demonstrated as a valid method to fabricate a tough hydrogel.…”

Section: Strategies To Construct Tough Hydrogelsmentioning

confidence: 99%

“…The hydrophobic segments self-assembled in the presence of water and contributed to the energy dissipation via chain slippage and disentanglements under loading. Incorporation of gelatin microgels [83] or chitin nanocrystals [29] into catechol-containing hydrogel introduces extra non-covalent crosslinks to the network, contributing to about 2–3-fold increases in adhesive strength.…”

Section: Tough Hydrogels As Tissue Adhesivesmentioning

confidence: 99%

Recent Developments in Tough Hydrogels for Biomedical Applications

Liu

He²,

Zhang

et al. 2018

Gels

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A hydrogel is a three-dimensional polymer network with high water content and has been attractive for many biomedical applications due to its excellent biocompatibility. However, classic hydrogels are mechanically weak and unsuitable for most physiological load-bearing situations. Thus, the development of tough hydrogels used in the biomedical field becomes critical. This work reviews various strategies to fabricate tough hydrogels with the introduction of non-covalent bonds and the construction of stretchable polymer networks and interpenetrated networks, such as the so-called double-network hydrogel. Additionally, the design of tough hydrogels for tissue adhesive, tissue engineering, and soft actuators is reviewed.

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Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive

Cited by 44 publications

References 46 publications

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications

Recent Developments in Tough Hydrogels for Biomedical Applications

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