Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate

Abruzzo, Angela; Bigucci, Federica; Cerchiara, Teresa; Saladini, Bruno; Gallucci, Maria Caterina; Cruciani, Federica; Vitali, Beatrice; Luppi, Barbara

doi:10.1016/j.carbpol.2012.08.074

Cited by 88 publications

(66 citation statements)

References 32 publications

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“…In the alginate spectrum, it is possible to identify a band at wavelength value of 1609 cm −1 , which is close to that found by Abruzzo et al [28] and indicates the C = O group. In the gelatin spectrum, it is possible to observe a band characteristic of the amide group, at the wavelength of 1545.0 cm −1 , near that found by Yakimets et al [29] The characteristic peaks at 2928 and 2858 cm −1 of buriti oil were identified in all microcapsules, indicating their presence in the particles.…”

Section: Fourier-transform Infrared Spectroscopysupporting

confidence: 68%

Particle size characteristics of buriti oil microcapsules produced by gelatin-sodium alginate complex coacervation: Effect of stirring speed

Lemos

Marfil

Telis

2017

International Journal of Food Properties

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The influence of hydrodynamic conditions in the coacervation medium of the carotenoid-rich buriti oil using gelatin-alginate as wall materials was investigated. The stirring speed had strong influence on the size of the microcapsules, and Reynolds number higher than 70000 resulted in particle size D [4,3] lower than 200 μm. The carotenoid encapsulation efficiency was around 80%, with freeze-dried particles presenting intense yellow color. Although the size of the microparticles was highly dependent on the hydrodynamic conditions during coacervate formation, complex coacervation of gelatin and sodium alginate showed to be a feasible process to producing buriti oil microcapsules. ARTICLE HISTORY

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Section: Fourier-transform Infrared Spectroscopysupporting

confidence: 68%

Particle size characteristics of buriti oil microcapsules produced by gelatin-sodium alginate complex coacervation: Effect of stirring speed

Lemos

Marfil

Telis

2017

International Journal of Food Properties

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“…Several studies revealed that the presence of crosslinker influenced CS mucoadhesiveness as a result of a drop in positively charged free amino groups, reducing the polymer chains' mobility and ability to interact with mucosal surface [9,51]. Surprisingly, CS/β-GP hydrogels were noticed to possess comparable (F4 vs. F2) or even higher (F3 vs. F1) values of mucoadhesive properties.…”

Section: Swelling Index and Mucoadhesion Studiesmentioning

confidence: 99%

“…In the recent years, mucoadhesive delivery systems providing intimate contact between a dosage form and the vaginal mucosa have gained a great attention [3,4]. Among mucoadhesive polymers, chitosan (CS) is extensively studied in designing ocular [5], buccal [6], nasal [7], and vaginal dosage forms [8,9]. In addition, CS is currently receiving great interest in pharmaceutical and biomedical fields, particularly because of its penetration enhancement capability [10,11] and antifungal activity [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application

et al. 2015

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Mucoadhesive gelling systems based on chitosan and chitosan/β-glycerophosphate (β-GP) were developed in order to increase clotrimazole residence time in the vaginal cavity. Ex vivo mucoadhesiveness using porcine vaginal mucosa followed with mechanical, viscoelastic, and swelling properties of prepared hydrogels were evaluated. Drug-free, sterile, unmodified, and β-GP crosslinked chitosan were investigated for the in vitro cytotoxicity in CRL 2616 human vaginal mucosa cells using MTT assay, fluorescent microscopy, and flow cytometry analysis. Chitosan/β-GP hydrogels exhibited pseudoplastic and thixotropic properties. Ionic interaction between β-GP and chitosan improved mechanical properties of hydrogels in terms of hardness, cohesiveness, and compressibility. The hydrogels' ability to interact with porcine vaginal mucosa (measured as force of detachment and work of adhesion) was comparable to those obtained with reference mucoadhesive gel Replens™. Surprisingly, greater mucoadhesive properties were noticed for chitosan/β-GP hydrogels. The cytotoxic effect of unmodified and β-GP crosslinked chitosan was hardly affected by chitosan molecular weight, exhibited mainly through inducing apoptosis, and was found to be significantly lower in the presence of chitosan/β-GP. Furthermore, the higher amount of β-GP was used to crosslink chitosan, the lower cytotoxic effect was observed.

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“…In contrast, the sol phase of respiratory mucus is thought to be cleared much less rapidly than the more solid-like luminal gel layer [24][25][26][27] . Continuous secretion and clearance by peristaltic forces leads to quick turnover times, on the order of 4 -6 h, in the rat GIT 7,28,29 and likely similar values in humans. In the vagina, mucus is cleared (expelled through the introitus) by intra-abdominal pressure as well as abdominal motions, which squeeze the walls of the vagina together 30,31 .…”

Section: Bioadhesionmentioning

confidence: 90%

Untitled

2017

IJPSR

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Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable drugs.

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Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate

Cited by 88 publications

References 32 publications

Particle size characteristics of buriti oil microcapsules produced by gelatin-sodium alginate complex coacervation: Effect of stirring speed

Particle size characteristics of buriti oil microcapsules produced by gelatin-sodium alginate complex coacervation: Effect of stirring speed

The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application

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