Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?

Kedjarune‐Leggat, Ureporn; Leggat, Peter A.

doi:10.5772/18831

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…and Rabea (2017), the transfection efficiency of chitosan depends on the degree of acetylation, molecular weight, pH of the transfecting media, cell type, and the charge ratio of the luciferase plasmid to chitosan. Limitations in the use of chitosan for non-viral gene therapy were previously reported by Kedjarune-Leggat and Leggat (2011). Most of the results on gene therapy using chitosan were obtained from experiments in vitro, and further research is needed in vivo.…”

Section: Medicinementioning

confidence: 99%

Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry

et al. 2019

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Chitosan is a biopolymer obtained from chitin, one of the most abundant and renewable materials on Earth. Chitin is a primary component of cell walls in fungi, the exoskeletons of arthropods such as crustaceans, e.g., crabs, lobsters and shrimps, and insects, the radulae of molluscs, cephalopod beaks, and the scales of fish and lissamphibians. The discovery of chitin in 1811 is attributed to Henri Braconnot while the history of chitosan dates back to 1859 with the work of Charles Rouget. The name of chitosan was, however, introduced in 1894 by Felix Hoppe-Seyler. Chitosan has attracted major scientific and industrial interests from the late 1970s due to its particular macromolecular structure, biocompatibility, biodegradability and other intrinsic functional properties. Chitosan and derivatives have practical applications in the food industry, agriculture, pharmacy, medicine, cosmetology, textile and paper industries, and in chemistry. In recent years, chitosan has also received much attention in dentistry, ophthalmology, biomedicine and bioimaging, hygiene and personal care, veterinary medicine, packaging industry, agrochemistry, aquaculture, functional textiles and cosmetotextiles, catalysis, chromatography, beverage industry, photography, wastewater treatment and sludge dewatering, and biotechnology. Nutraceuticals and cosmeceuticals are actually growing markets, and therapeutic and biomedical products should be the next markets in the development of chitosan. Chitosan is also the object of numerous fundamental studies. In this review, we highlight a selection of works on chitosan applications published over the past two decades.

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Section: Medicinementioning

confidence: 99%

Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry

et al. 2019

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“…Genetic materials such as deoxyribonucleic acids and ribonucleic acid are used in gene therapy as pharmaceutical agents to treat various diseases (Lee 2007;Dash et al 2011;Kedjarune-Leggat and Leggat 2011;Choi et al 2016;Badawy and Rabea 2017). However, the use of genetic materials is limited due to rapid degradation by nuclease, large size, poor cellular uptake, high anionic charge density, and also non-specificity.…”

Section: Medicinementioning

confidence: 99%

“…As recently reviewed by Badawy and Rabea (2017), the transfection efficiency of chitosan depends on the degree of acetylation, molecular weight, pH of the transfecting media, cell type, and the charge ratio between the luciferase plasmid to chitosan. Limitations in the use of chitosan for non-viral gene therapy were previously reported by Kedjarune-Leggat and Leggat (2011). Most of the results on gene therapy using chitosan were obtained from experiments in vitro and further research is needed in vivo.…”

Section: Medicinementioning

confidence: 99%

Fundamentals and Applications of Chitosan

Morin‐Crini

Lichtfouse

Torri

et al. 2019

Sustainable Agriculture Reviews

103

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Chitosan is a biopolymer obtained from chitin, one of the most abundant and renewable material on Earth. Chitin is a primary component of cell walls in fungi, the exoskeletons of arthropods, such as crustaceans, e.g. crabs, lobsters and shrimps, and insects, the radulae of molluscs, cephalopod beaks, and the scales of fish and lissamphibians. The discovery of chitin in 1811 is attributed to Henri Braconnot while the history of chitosan dates back to 1859 with the work of Charles Rouget. The name of chitosan was, however, introduced in 1894 by Felix Hoppe-Seyler. Because of its particular macromolecular structure, biocompatibility, biodegradability and other intrinsic functional properties, chitosan has attracted major scientific and industrial interests from the late 1970s. Chitosan and its derivatives have practical applications in food industry, agriculture, pharmacy, medicine, cosmetology, textile and paper industries, and chemistry. In the last two decades, chitosan has also received much attention in numerous other fields such as dentistry, ophthalmology, biomedicine and bio-imaging, hygiene and personal care, veterinary medicine, packaging industry, agrochemistry, aquaculture, functional textiles and cosmetotextiles, catalysis, chromatography, beverage industry, photography, wastewater treatment and sludge dewatering, and biotechnology. Nutraceuticals and cosmeceuticals are actually growing markets, and therapeutic and biomedical products should be the next markets in the development of chitosan. Chitosan is also the object of numerous fundamental studies. An indication of the widespread exploitation and constantly growing importance of this biopolymer is the total of over 58,625 scientific articles published between 2000 and 2017. In this chapter, after a description of chitosan fundamentals, we highlight selected works on chitosan applications published over the last two decades.

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