Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administration

Oral Methylated N-Aryl Chitosan Derivatives for Inducing Immune Responses to Ovalbumin

“…The adjuvant activity of TM 65 CS was the lowest. This result was in agreement with the observations of a previous study which showed that TMC with 60 % of DQ showed a low immune response and no significant difference in comparison to control and lower DQ of TMC groups [15].…”

“…Moreover, CS and its derivatives, TMC, exhibit immunoadjuvants and antigen delivery systems for mucosal vaccinations [15]. Fig 2a shows (Fig 2a).…”

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

“…The 1 H-NMR analysis reported in Supplementary Figure 2 revealed that the degree of quaternization of the polymer was 50%. This value is close to the value of 48% found in the literature by Hamman et al (2003) to give the best effect on TEER and transport of hydrophilic macromolecules across Caco-2 monolayer cells; higher degrees of quaternization (55% and 59%) did not improve these properties, which they attributed to steric hindrance by the additional methyl groups and increased flexibility of the molecules, a similar effect was observed by Boonyo et al (2007).…”

Vaccine adjuvants: Current challenges and future approaches

“…87,[165][166][167][168][169][170][171][172][173][174][175][176] Other classes of polymeric compounds have been evaluated and shown to successfully deliver antigen to laboratory animals. [177][178][179][180][181][182][183][184][185][186][187][188][189][190] Key findings of research done with these polymeric systems as vaccines carriers are discussed below and the chemistries are shown in Table 4.…”