Chitosan-based hydrogel wound dressing: From mechanism to applications, a review

Chitosan-based hydrogels: From preparation to applications, a review

“…The formation of the hydrogel is mainly driven by the intermolecular self-assembly of these components through hydrogen bonding. The resulting hydrogel exhibits dual responsiveness to temperature and pH and has great potential in the field of gastrointestinal drug release ( Wang et al, 2023 , Yang et al, 2023 , Zhao et al, 2023 ).…”

“…The intricate network architecture of chitosan-based hydrogels offers a versatile platform for incorporating various bioactive compounds, thereby enabling a broad spectrum of applications in the realms of tissue engineering, drug delivery, food science, and beyond. With the ability to imbibe or contract in response to external stimuli, these hydrogels have demonstrated immense potential for a diverse array of fields ( Zhao et al, 2023 , Yang et al, 2023 ). Considering the growing prominence of green chemistry and the urgent need for environmental preservation, chitosan-based hydrogels have emerged as a promising alternative to conventional biodegradable materials.…”

Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings

“…This complex chitosan-based hydrogel possesses excellent antibacterial activity, antioxidant properties, good hemostasis, and cytocompatibility and can be used to support wound healing as a wound-healing dressing ( Figure 6 C) [ 109 ]. The antibacterial activity can be further and significantly enhanced by encapsulating drugs or adding antibacterial agents in chitosan-based hydrogels [ 110 , 111 ]. There is another work using the strategy of combining quaternary ammonium chitosan and silver nanoparticles using a one-pot method to develop antimicrobial hydrogel wound dressings that are more efficient and synergistic than chitosan derivatives alone [ 112 ].…”

“…It relies on glycoprotein on the platelet membrane for signal activation and conduction and then works with collagen and fibrinogen to agglutinate the platelets into thrombi. In addition, a small amount of negative substance present on the surface of activated platelets can also bind to chitosan and promote platelet aggregation [ 111 , 112 , 113 , 114 ].…”

Clinical Applicable Carboxymethyl Chitosan with Gel-Forming and Stabilizing Properties Based on Terminal Sterilization Methods of Electron Beam Irradiation

“…Hydrogels, which can be categorized into natural and synthetic hydrogels, have gained a great deal of attention in the field of tissue engineering, , wound dressings, implants, and other medical materials because of their good biocompatibility and unique three-dimensional cross-linked network structure . Compared with synthetic hydrogels, natural hydrogels are composed of chitosan, sodium alginate, hyaluronic acid, cellulose, and other natural polysaccharides that have the advantages of high stability, nontoxicity, good biocompatibility, and biodegradability . Among them, chitosan is the only alkaline polysaccharide with an amino group on its monomer in nature, which has excellent biocompatibility and biodegradability, making it widely researched in the biomedical field. , While chitosan is only soluble in moderately acidic environments due to the protonation of amino groups at pH < 6.5, it thus limits many of its potential applications .…”