Chitosan‐based Interpenetrating Polymeric Network Systems for Sustained Drug Release

Nayak, Amit Kumar; Pal, Dilip Kumar

doi:10.1002/9781118998922.ch7

Cited by 13 publications

(2 citation statements)

References 92 publications

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“…CS is derived from chitin, which is found on the shells of crustaceans, via alkaline deacetylation [42]. The structure of CS comprises N -acetyl glucosamine units that are positively charged, giving this polymer its mucoadhesive property [43].…”

Section: Polymeric Nanomaterials: Properties and Applications In Imentioning

confidence: 99%

Polymer-Based Nanoparticle Strategies for Insulin Delivery

et al. 2019

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Diabetes mellitus (DM) is a chronic metabolic illness estimated to have affected 451 million individuals to date, with this number expected to significantly rise in the coming years. There are two main classes of this disease, namely type 1 diabetes (T1D) and type 2 diabetes (T2D). Insulin therapy is pivotal in the management of diabetes, with diabetic individuals taking multiple daily insulin injections. However, the mode of administration has numerous drawbacks, resulting in poor patient compliance. In order to optimize insulin therapy, novel drug delivery systems (DDSes) have been suggested, and alternative routes of administration have been investigated. A novel aspect in the field of drug delivery was brought about by the coalescence of polymeric science and nanotechnology. In addition to polymeric nanoparticles (PNPs), insulin DDSes can incorporate the use of nanoplatforms/carriers. A combination of these systems can bring about novel formulations and lead to significant improvements in the drug delivery system (DDS) with regard to therapeutic efficacy, bioavailability, increased half-life, improved transport through physical and chemical barriers, and controlled drug delivery. This review will discuss how recent developments in polymer chemistry and nanotechnology have been employed in a multitude of platforms as well as in administration routes for the safe and efficient delivery of insulin for the treatment of DM.

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Section: Polymeric Nanomaterials: Properties and Applications In Imentioning

confidence: 99%

Polymer-Based Nanoparticle Strategies for Insulin Delivery

et al. 2019

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“…2 The current socio-economic situation of the modern world has elevated the interest on the use of natural polysaccharides as replacement of synthetic biopolymers in various biomedical applications. [3][4][5][6] Natural polysaccharides are obtained from algal, plant, animal and microbial origin. 7 With the improvement of biotechnology, several natural polysaccharides are produced in vitro by enzymatic process.…”

Section: Introductionmentioning

confidence: 99%

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

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Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, tablets, gels, creams, beads, spheroids, microparticles, nanoparticles, ophthalmic preparations, and buccal patches, etc. The current chapter deals with a comprehensive and useful discussion on pharmaceutical applications of tamarind seed polysaccharide withits some important features like source, isolation, chemical composition and properties.

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Plant Polysaccharides Blended Ionotropically Gelled Alginate Multiple Unit Systems for Sustained Drug Release

Pal

Nayak²

2017

Handbook of Composites From Renewable Materials

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Chitosan‐based Interpenetrating Polymeric Network Systems for Sustained Drug Release

Cited by 13 publications

References 92 publications

Polymer-Based Nanoparticle Strategies for Insulin Delivery

Polymer-Based Nanoparticle Strategies for Insulin Delivery

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Plant Polysaccharides Blended Ionotropically Gelled Alginate Multiple Unit Systems for Sustained Drug Release

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