Chitosan-based nanoparticles against bacterial infections

Rashki, Somaye; Asgarpour, Kasra; Tarrahimofrad, Hossein; Hashemipour, Maryam Alsadat; Ebrahimi, Mohammad Saeid; Fathizadeh, Hadis; Kazemi, Ahmad; Khan, Haroon; Marzhoseyni, Zeynab; Salavati‐Niasari, Masoud; Mirzaei, Hamed

doi:10.1016/j.carbpol.2020.117108

Cited by 268 publications

(146 citation statements)

References 133 publications

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“…The mean degree of deacetylation is usually >60% ( Ng et al., 2002 ; Varma et al., 2004 ). The average degree of deacetylation and the molecular weight specifies the total number of amide residues and the number of primary amine residues, and this ratio directly influences the CH solubility and the chemical, biological and physical properties ( Kmiec et al., 2017 ; Jaworska et al., 2020 ; Rashki et al., 2020 ; Yang et al., 2020a ).…”

Section: Chitosan (Ch) and Ch Npsmentioning

confidence: 99%

“…Chitosan (CH) is a modified biopolymer obtained via partial de-acetylation of the naturally occurring polysaccharide called chitin, which contains randomly distributed (1! 4)-linked Nacetyl glucosamine and glucosamine units (Rashki et al, 2021). CH can be obtained as a white powder, composed of rigid, inflexible, and nitrogen-containing polysaccharide chains of varying length and molecular weight (Badawy and Rabea, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Chitosan-Based Nanoparticles Against Viral Infections

Boroumand

Badie

Mazaheri

et al. 2021

Front. Cell. Infect. Microbiol.

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111

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Viral infections, in addition to damaging host cells, can compromise the host immune system, leading to frequent relapse or long-term persistence. Viruses have the capacity to destroy the host cell while liberating their own RNA or DNA in order to replicate within additional host cells. The viral life cycle makes it challenging to develop anti-viral drugs. Nanotechnology-based approaches have been suggested to deal effectively with viral diseases, and overcome some limitations of anti-viral drugs. Nanotechnology has enabled scientists to overcome the challenges of solubility and toxicity of anti-viral drugs, and can enhance their selectivity towards viruses and virally infected cells, while preserving healthy host cells. Chitosan is a naturally occurring polymer that has been used to construct nanoparticles (NPs), which are biocompatible, biodegradable, less toxic, easy to prepare, and can function as effective drug delivery systems (DDSs). Furthermore, chitosan is Generally Recognized as Safe (GRAS) by the US Food and Drug Administration (U.S. FDA). Chitosan NPs have been used in drug delivery by the oral, ocular, pulmonary, nasal, mucosal, buccal, or vaginal routes. They have also been studied for gene delivery, vaccine delivery, and advanced cancer therapy. Multiple lines of evidence suggest that chitosan NPs could be used as new therapeutic tools against viral infections. In this review we summarize reports concerning the therapeutic potential of chitosan NPs against various viral infections.

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Section: Chitosan (Ch) and Ch Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nanoparticles Against Viral Infections

Boroumand

Badie

Mazaheri

et al. 2021

Front. Cell. Infect. Microbiol.

Self Cite

111

View full text Add to dashboard Cite

show abstract

“…[ 84 ]. Specifically, chitosan is a positively charged polysaccharide owning favorable membrane penetration and mucoadhesion properties and thus is typically employed to aid gene transfection, intracellular delivery, and mucodelivery [ 87 – 89 ]. Contrary to chitosan, alginate and HA are anionic polymers presenting superior safety and have been extensively used in drug delivery and tissue engineering [ 90 ].…”

Section: Rationality Of Nanoplatforms In Sepsis Managementmentioning

confidence: 99%

Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis

et al. 2021

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Sepsis, a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection, is a leading contributor to mortality in intensive care units. Sepsis-related deaths have been reported to account for 19.7% of all global deaths. However, no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis. Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis. Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry, targeting infection and/or imbalanced immune responses, have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment. Nanoplatforms can overcome the barriers faced by clinical strategies, including delayed diagnosis, drug resistance and incapacity to manage immune disorders. Here, we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts, summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies. Based on these state-of-the-art studies, this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis."Image missing"

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“…[ 17 ] Many products based on chitosan have been used in various medical fields such as tissue engineering, drug delivery, eye application, and joint injection. [ 18–21 ] Moreover, chitosan can promote wound healing and possess good antibacterial ability, [ 22,23 ] but its mechanical properties are poor. This problem is usually solved by blending with other polymers.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Polyvinyl Alcohol‐Chitosan/Cerium Hydrogel with Significant Antibacterial Activity

et al. 2021

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Traditional wound dressings have some major deficiencies, including poor antibacterial ability, low exudate absorption rate and dry environment. These defects can be addressed by the prepared hydrogels in this study, which can provide a moist and cool environment for wound healing. Polyvinyl alcohol‐chitosan/cerium (PVA‐Cs/Ce) composite hydrogels are prepared by a freeze‐thaw method and characterized by x‐ray diffraction (XRD) and scanning electron microscopy (SEM). In addition, the effects of chitosan/cerium (Cs/Ce) complexes with different contents on properties, including mechanical properties, water vapor permeability, swelling ratio, and thermal stability are investigated. SEM images indicate that the composite hydrogels have a good three‐dimensional pore structure. Compared with the pure PVA hydrogel, the composite hydrogels show better swelling properties and more suitable water vapor transmission rate (2504 g m‐2·day) by adding Cs/Ce complexes. And the elongation at break of the hydrogel with a ratio of 5:3 (PVA: Cs/Ce) is the highest value of 567%. In the bacteriostatic circle experiment, PVA‐Cs/Ce composite hydrogels exhibit a pronounced inhibitory effect against two bacteria (Staphylococcus aureus and Escherichia coli). These results suggest that these composite hydrogels have great potential as wound dressings.

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Chitosan-based nanoparticles against bacterial infections

Cited by 268 publications

References 133 publications

Chitosan-Based Nanoparticles Against Viral Infections

Chitosan-Based Nanoparticles Against Viral Infections

Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis

Preparation and Characterization of Polyvinyl Alcohol‐Chitosan/Cerium Hydrogel with Significant Antibacterial Activity

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