Chitosan-based nanoparticles for ocular drug delivery

Pal, Kunal; Pradhan, Bikash K.; Kim, Doman; Jarzębski, Maciej

doi:10.1016/b978-0-323-88524-9.00023-1

Cited by 3 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6][7][8][9][10] Moreover, the addition of chitosan can improve the solubility, 11 bioavailability, 12 and mucoadhesive properties 13 of drug delivery systems. Chitosan nanoparticles have been applied in various drug delivery systems, such as colonic drug delivery, 4 nucleic acid drug delivery, 14 ocular drug delivery, 15 peroral delivery, [16][17][18][19][20] pulmonary drug delivery, 21 nasal drug delivery, 22 mucosal drug delivery, 23 gene delivery, 24 vaccine delivery and 25 vaginal drug delivery, 26 as well as for cancer therapy. 27 Despite their many advantages and practical uses, chitosan nanoparticles for drug delivery still face certain obstacles, such as their insoluble nature in neutral and alkaline pH solutions, which restricts their application to environments such as the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

Huanbutta,

Sriamornsak,

Suwanpitak

et al. 2023

IJN

View full text Add to dashboard Cite

Introduction Chitosan nanoparticles have garnered considerable interest in the field of drug delivery owing to their distinctive properties, including biocompatibility, biodegradability, low toxicity, and ability to encapsulate a wide range of drugs. However, the conventional methods (eg, the drop method) for synthesizing chitosan nanoparticles often face limitations in regard to controlling the particle size, morphology, and scalability, hindering their extensive application in drug delivery systems. To overcome these challenges, this study explores using a novel flow chemistry reactor design for fabricating clindamycin-loaded chitosan nanoparticles. Methods By varying two critical operating parameters of flow chemistry, namely, the flow rate ratio and total flow rate, the impact of these parameters on the properties of chitosan nanoparticles is investigated using a central composite experimental design. Results The optimized conditions for nanoparticle preparation yielded remarkable results, with chitosan nanoparticles exhibiting a small size of 371.60 nm and an extremely low polydispersity index of 0.042. Furthermore, using novel design flow chemistry reactor, the productivity of chitosan nanoparticles was estimated to be 25,402.17 mg/min, which was ~12.71 times higher than that obtained via batch synthesis. Conclusion The findings of this study indicate that the use of novel design flow chemistry reactor is promising for synthesizing clindamycin-loaded chitosan nanoparticles and other polymeric nanoparticles intended for drug delivery applications. This is primarily attributed to their ability to produce nanoparticles with a considerably reduced particle size distribution and smaller overall size. The demonstrated high productivity of this technique suggests the potential for industrial-scale nanoparticle manufacturing.

show abstract