Chitosan-based systems for oral drug delivery applications

Das, Sabya Sachi; Kar, Sweta; Singh, Sandeep Kumar; Verma, Pankaj; Hussain, Afzal; Beg, Sarwar

doi:10.1016/b978-0-12-819336-5.00009-1

Cited by 7 publications

(4 citation statements)

References 125 publications

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“…It is a potential carrier for drug delivery applications due to its biodegradability, biocompatibility, and mucoadhesive properties. 62 Cationic chitosan polymer particles can be obtained by various methods, including emulsion crosslinking, 63 polyelectrolyte complexation, 64 and the most widely used ionic gelation method. 65 Studies have shown that chitosan strongly attracts the sialic acid (negatively charged) residues over the red blood cells, leading to severe hemagglutination.…”

Section: Natural Cationic Polymers: Preparation Methods and Anticance...mentioning

confidence: 99%

Natural cationic polymer-derived injectable hydrogels for targeted chemotherapy

Das,

Sharma,

Rao

et al. 2023

Mater. Adv.

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Section: Natural Cationic Polymers: Preparation Methods and Anticance...mentioning

confidence: 99%

Natural cationic polymer-derived injectable hydrogels for targeted chemotherapy

Das,

Sharma,

Rao

et al. 2023

Mater. Adv.

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“…The small intestine can also be a target for local treatment, but it is the favorite site for drug absorption, due to its large surface area, being arranged into crypt structures. Several studies demonstrated the protective effect of CS-based drug delivery systems against acidic denaturation and enzymatic degradation, as well as its reversible enhancer effect on the intestinal absorption and its ability to prolong the intestinal residence time due to its intrinsic mucoadhesive characteristics [ 295 ].…”

Section: Chitosan-based Mucosal Drug Delivery Systemsmentioning

confidence: 99%

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

et al. 2022

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Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.

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“…It interacts actively with biological cells/tissues and promotes regeneration, and tissue growth. Besides these, CM–CS has antimicrobial, antifungal, anti-inflammatory, antitumor, tissue engineering, diagnostics, and advanced drug delivery technologies. − CM–CS prevents biofilm formation and adherence of bacterial strains of both Gram-positive and Gram-negative bacteria, resulting in reduced cell-to-cell interaction and microbial floccules formed. Further, the amino group in CM–CS gets protonated in the physiological media and has a high affinity to bind with anionic group microbes and inhibit .…”

Section: Introductionmentioning

confidence: 99%

Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity

Almeleebia,

Akhter,

Khalilullah

et al. 2024

ACS Omega

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A novel combination of antibiotic, ciprofloxacin (CIP) with herbal counterpart naringin (NAR) was encapsulated by an oleic acid lipid core and carboxymethyl chitosan (CM−CS)/Alginate (AG) nanoparticle composite (CIP + NAR−CM−CS/AG−NPs) for improved antimicrobial efficacy of antibiotic. Herein, this study explored the design and preparation of a composite system that enables to deliver both CIP and NAR from the oleic acid lipid core of CM− CS/AG nanoparticles using a nonsolvent ionic gelation technique. The nanoparticles (NPs) were fabricated with improved long-acting antimicrobial activity against E. coli and S. aureus. The optimized composition was investigated for physicochemical properties particle size, particle distribution, and ζ−potential. A diverse array of analytical tools was employed to characterize the optimized formulation including DSC, XRD, Malvern Zetasizer for particle size, ζ−potential, TEM, and SEM. Further, the preparation was investigated for % drug release, flux determination, antioxidant, and antimicrobial activity. The formulation stability was tested for 90 days and also evaluated formulation stability in fetal bovine serum to inspect the modification in physicochemical characteristics. NPs size was determined at 85 nm, PDI, and ζ−potential was recorded at 0.318, and 0.7 ± 0.4 mV. The % CIP and NAR entrapment efficiency and % loading were incurred as 91 ± 1.9, and 89.5 ± 1.2; 11.5 ± 0.6, and 10.8 ± 0.5%, respectively. The drug release erupted in the beginning phase followed by sustained and prolonged release for 48 h. The analytical experiments by DSC ensured the noninteracting and safe use of excipients in combination. X−ray studies demonstrated the amorphous state of the drug in the formulation. The insignificant alteration of formulation characteristics in FBS suggested stable and robust preparation. Storage stability of the developed formulation ensured consistent and uniform stability for three months. The DPPH assays demonstrated that NAR had good antioxidant capacity and supported improving antimicrobial activity of CIP. The hemolytic test suggested the developed formulation was compatible and caused insignificant RBC destruction. The in-house built formulation CIP + NAR−CM−CS/AG−NPs significantly improved the antimicrobial activity compared to CIP alone, offering a novel choice in antimicrobial application.

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Chitosan-based systems for oral drug delivery applications

Cited by 7 publications

References 125 publications

Natural cationic polymer-derived injectable hydrogels for targeted chemotherapy

Natural cationic polymer-derived injectable hydrogels for targeted chemotherapy

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity

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