Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy

Yan, Tingsheng; He, Jinmei; Liu, Rongmei; Z, Liu; Cheng, Jason Chia‐Hsien

doi:10.1016/j.carbpol.2019.115706

Cited by 91 publications

(44 citation statements)

References 46 publications

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“…As a result of loading CSL in the cavity, a new peak was detected at 1702 cm −1 corresponding to the vibrations of C=O. The characteristic absorption peak of Cs at 1650 and 1380 cm −1 indicated the successful coating of the CS layer [18].…”

Section: Synthesis and Characterization Of Csl@hmsns-csmentioning

confidence: 96%

“…Osteoarthritis can provide acidic environments to protonate free NH 2 groups and improve the water solubility of Cs. The CS layer swells, leading to the exposure of pore entrances and the release of drugs was triggered [18]. Medical Cs are intra-articular injected for clinical application, given their protective action on osteoarthritis by preventing type II collagen degradation [25].…”

Section: Synthesis and Characterization Of Csl@hmsns-csmentioning

confidence: 99%

“…Chitosan is an amino-polysaccharide with advantages of biocompatibility and natural nontoxicity. Chitosan is often chosen as a gatekeeper due to its pH responsiveness and control the release of cargo drugs of nanoparticles in different pH environments [18]. The pH-sensitive nanocomplex that diffuses in the joint cavity is concentrated released in the areas with severe inflammation, which also means the chondrocytes in the acidic microenvironment.…”

Section: Introductionmentioning

confidence: 99%

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Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Jin

Liu

et al. 2020

J Nanobiotechnol

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Background: Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory environment. Our aim was to load celastrol into HMSNs and capped with chitosan to construct a pH-responsive nanoparticle medicine (CSL@HMSNs-Cs), which is of high solubility for osteoarthritis intra-articular injection treatment.

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Section: Synthesis and Characterization Of Csl@hmsns-csmentioning

confidence: 96%

Section: Synthesis and Characterization Of Csl@hmsns-csmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Jin

Liu

et al. 2020

J Nanobiotechnol

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“…HDFSNs-GM-CS-FA@DOX/PA fully combined photothermal, photodynamic and chemotherapies to develop synergistic antitumor efficacy. 119 In another study, DOX was loaded into DFSN then coated with AgNPs. The synthesized DOX/AgNPs/DFSN was injected to cancerous cells via endocytosis.…”

Section: Gene Therapymentioning

confidence: 99%

Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges

Shaban

Hasanzadeh

2020

RSC Adv.

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“…Chitosan is an amino-polysaccharide with advantages of biocompatibility and natural nontoxicity. Chitosan is often chosen as a gatekeeper due to its pH responsiveness and control the release of cargo drugs of nanoparticles in different pH environments (18). The pH-sensitive nanocomplex that diffuses in the joint cavity is concentrated released in the areas with severe in ammation, which also means the chondrocytes in the acidic microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Intra-articular Delivery of Celastrol by Hollow Mesoporous Silica Nanoparticles for pH-sensitive Anti-inflammatory Therapy against Knee Osteoarthritis

Jin

Liu

et al. 2020

Preprint

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Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory environment. Our aim was to load celastrol into HMSNs and capped with chitosan to construct a pH-responsive nanoparticle medicine(CSL@HMSNs-Cs), which is of high solubility for osteoarthritis intra-articular injection treatment. Methods: The CSL@HMSNs-Cs were assembled and the characteristics were measured. The CSL@HMSNs-Cs was applied in vitro in the chondrocytes collected from rats cartilage tissue and in vivo in the MIA induced knee osteoarthritis rats via intra-articular injection. Cytotoxicity assay, pH-responsive release, pain behavior, MRI, safranin o fast green staining, ELISA and western blot analysis were applied to evaluate the bioavailability and therapeutic effect of CSL@HMSNs-Cs.Results: CSL@HMSNs-Cs was stable due to the protection of the chitosan layers in alkaline environment(pH=7.7) but revealed good solubility and therapeutic effect in acidic environment(pH=6.0). The cytotoxicity assay showed no cytotoxicity at relatively low concentration(200 μg/mL) and the cell viability of chondrocytes stimulated by IL-1β was increased in CSL@HMSNs-Cs group. Paw withdrawal threshold in CSL@HMSNs-Cs group is increased, and MRI and Safranin O Fast Green staining showed improvements in articular surface erosion and joint effusion. The upregulated expression levels of IL-1β, TNF-α, IL-6, MMP-3 and MMP-13 and NF-κB signaling pathway of chondrocytes were inhibited in CSL@HMSNs-Cs group.Conclusion: Hollow mesoporous silica nanoparticles were an ideal carrier for natural drugs with poor solubility and were of high biocompatibility for intra-articular injection. These intra-articular injectable CSL@HMSNs-Cs with improved solubility, present a pH-responsive therapeutic strategy against osteoarthritis.

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Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy

Cited by 91 publications

References 46 publications

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges

Intra-articular Delivery of Celastrol by Hollow Mesoporous Silica Nanoparticles for pH-sensitive Anti-inflammatory Therapy against Knee Osteoarthritis

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