Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges

Shaban, Mina; Hasanzadeh, Mohammad

doi:10.1039/d0ra04388e

Cited by 35 publications

(13 citation statements)

References 129 publications

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“…Currently,t here are several review papers [7,[35][36][37][38][39][40][41] on the synthesis and applications of this new type of MSNs,and all of these particles were classified as "dendritic mesoporous silica nanoparticles (DMSNs)". Thec onfusion about their structures and the debate on the formation mechanisms are not clearly addressed.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Xu,

Lei,

Wang

et al. 2022

Angew Chem Int Ed

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Recently, dendritic mesoporous silica nanoparticles with widespread applications have attracted great interest. Despite many publications (>800), the terminology “dendritic” is ambiguous. Understanding what possible “dendritic structures” are, their formation mechanisms and the underlying structure–property relationship is fundamentally important. With the advance of characterization techniques such as electron tomography, two types of tree‐branch‐like and flower‐like structures can be distinguished, both described as “dendritic” in the literature. In this Review, we start with the definition of “dendritic”, then provide critical analysis of reported dendritic silica nanoparticles according to their structural classification. We update the understandings of the formation mechanisms of two types of “dendritic” nanoparticles, highlighting how to control their structural parameters. Applications of dendritic mesoporous nanoparticles are also reviewed with a focus on the biomedical field, providing new insights into the structure–property relationship in this family of nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Xu,

Lei,

Wang

et al. 2022

Angew Chem Int Ed

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“…12 In this regard, wrinkled fibrous nano-silica (WFNS) have attracted the attention of electrochemical immunoassay devices. 13 WFNS nanomaterials have been noted for their easy synthesis, adjustable particle size, large pore volume, excellent mechanical stability, low toxicity, complete biocompatibility, adjustable pore size, and unique large surfaces. 14 In the WFNS structure, the fibers resemble porous spheres that have a very accessible surface.…”

Section: Introductionmentioning

confidence: 99%

Sensitive recognition of prostate‐specific antigen using biotinylated antibody encapsulated on D‐penicillamine decorated wrinkled silicate nanoparticles (WSN): An innovative sandwich‐type biosensor toward diagnosis of prostate cancer

Behyar

Farshchi

Hasanzadeh

2022

J of Molecular Recognition

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In this study, a new sandwich-type biosensor was developed to specific recognition of prostate-specific antigen (PSA) and early-stage diagnosis of prostate cancer using encapsulation of biotinylated antibody (Ab1) of prostate-specific antigen on D-penicillamine decorated wrinkled silicate nanoparticles (WSN). For the first time, KCC-1-NH-DPA was synthesized and used to immobilization of biomacromolecules. So, fabricated immunosensor was performed by on sandwich-type strategy. After fabrication of immunosensor, cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry techniques were used to electrochemical evaluation of immune-platform for PSA detection. The proposed biocompatibility immune-platform provided a novel interface toward sensitive bioanalysis of PSA biomarker in human plasma samples. Due to the use of gold nanoparticles functionalized Cysteamine (Cys A) in the structure of the secondary antibody (Ab2 [HRP-Ab2]), the intensity of the electrochemical signal has increased, resulting in a more accurate detection of the target molecules. Under the right conditions, the engineering immunosensor provides good bioanalytical performance for determining the PSA biomarker in the linear range of 0.002 to 60 μg L À1 which low limit of quantification was 0.002 μg L À1 . As a result, it is suggested to use these immune-devices in the clinical pre-diagnosis of prostate cancer.

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“…There are a variety of nanoparticles that have been synthesized and applied to biomedical fields. Some of these include quantum dots, magnetic nanoparticles, optically active nanoparticles, carbon nanoparticles, emulsions, micelles, liposomes, microcapsules, microspheres, and thin films [9]. Each nanoparticle has its own unique characteristic and is beneficial for sensing, detecting, and diagnosing any disease.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials: Synthesis and Applications in Theranostics

et al. 2021

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Nanomaterials are endowed with unique features and essential properties suitable for employing in the field of nanomedicine. The nanomaterials can be classified as 0D, 1D, 2D, and 3D based on their dimensions. The nanomaterials can be malleable and ductile and they can be drawn into wires and sheets. Examples of nanomaterials are quantum dots (0D), nanorods, nanowires (1D), nanosheets (2D), and nanocubes (3D). These nanomaterials can be synthesized using top-down and bottom-up approaches. The achievements of 0D and 1D nanomaterials are used to detect trace heavy metal (e.g., Pb2+) and have higher sensitivity with the order of five as compared to conventional sensors. The achievements of 2D and 3D nanomaterials are used as diagnostic and therapeutic agents with multifunctional ability in imaging systems such as PET, SPECT, etc. These imaging modalities can be used to track the drug in living tissues. This review comprises the state-of-the-art of the different dimensions of the nanomaterials employed in theranostics. The nanomaterials with different dimensions have unique physicochemical properties that can be utilized for therapy and diagnosis. The multifunctional ability of the nanomaterials can have a distinct advantage that is used in the field of theranostics. Different dimensions of the nanomaterials would have more scope in the field of nanomedicine.

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Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges

Abstract: Dendritic fibrous nanosilica (DFNS) , with multi-component and hierarchically complex structures, has recently been receiving significant attention in various fields of nano-biomedicine.

Cited by 35 publications

References 129 publications

Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Sensitive recognition of prostate‐specific antigen using biotinylated antibody encapsulated on D‐penicillamine decorated wrinkled silicate nanoparticles (WSN): An innovative sandwich‐type biosensor toward diagnosis of prostate cancer

Nanomaterials: Synthesis and Applications in Theranostics

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