Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats

Tozaki, Hideyuki; Odoriba, Tomokazu; Okada, Naoki; Fujita, Takuya; Terabe, Akira; Suzuki, Tsutomu; Okabe, Susumu; Muranishi, Shozo; Yamamoto, Akira

doi:10.1016/s0168-3659(02)00084-6

“…94 Sistemas para liberação no cólon contendo paracetamol, mesalazina e insulina têm sido estudados com resultados satisfatórios. [97][98][99][100] enGenHaria de tecidos Engenharia de tecidos é um campo interdisciplinar que integra tecnologia e ciência para manter ou reparar os tecidos do corpo. Arcabouços (scaffolds) ou matrizes extracelulares são dispositivos utilizados na engenharia de tecidos como suportes que promovem a proliferação celular e o crescimento, fornecendo um ambiente estável.…”

Section: Figura 2 Microscopia Eletrônica De Varredura Das Microesferunclassified

Quitosana: biopolímero funcional com potencial industrial biomédico

Laranjeira¹,

Fávere²

2009

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Recebido em 27/1/09; aceito em 13/3/09; publicado na web em 2/4/09 CHITOSAN: FUNCTIONAL BYOPOLYMER WITH BIOMEDICAL INDUSTRIAL POTENTIAL. The importance of chitosan has grown significantly over the last two decades due to its renewable and biodegradable source, and also because of the recent increase in the knowledge of its functionality in the technological and biomedical applications. The present article reviews the biopolymer chitosan and its derivatives as versatile biomaterials for potential drug delivery systems, as well as tissue engineering applications, analgesia and treatment of arthritis.

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“…However, chitosan is prone to glycosidic hydrolysis by microbial enzymes in the colon (Chourasia, Jain, 2003;McConnell, Murdan, Basit, 2008;Muzzarelli, 2011). Furthermore, chitosan has been applied in colontargeted drug delivery systems in several forms such as capsules (Tozaki et al, 2002), matrices (Zambito, Di Colo, 2003), hydrogels (Zhang, Alsarra, Neau, 2002) and microspheres (Lorenzo-Lamosa et al, 1998). Therefore, the potential for chitosan to be used as a coating material is obvious.…”

Section: Introductionmentioning

confidence: 99%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2017

Braz. J. Pharm. Sci.

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The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.

show abstract

“…However, chitosan is prone to glycosidic hydrolysis by microbial enzymes in the colon (Chourasia, Jain, 2003;McConnell, Murdan, Basit, 2008;Muzzarelli, 2011). Furthermore, chitosan has been applied in colon-targeted drug delivery systems in several forms such as capsules (Tozaki, et al, 2002), matrices (Zambito, Di Colo, 2003), hydrogels (Zhang, Alsarra, Neau, 2002) and microspheres (Lorenzo-Lamosa et al, 1998). Therefore, the potential for chitosan to be used as a coating material is obvious.…”

Section: Introductionmentioning

confidence: 99%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2016

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/ gelatin complex film and a multilayer coating system. Uniterms: Chitosan/gelatin complex film/drugs coating. Chitosan/multilayer coating system/drugs coating. Drugs/delivery system/colon-targeted. Tablets/bilayer-coated.O objetivo desta pesquisa foi planejar um novo sistema de liberação de fármacos direcionado ao cólon, utilizando quitosana. Estudaram-se as propriedades dos filmes a fim de obter informações úteis sobre a aplicação desses filmes compósitos. Utilizaram-se os filmes compósitos em sistema de bicamada para investigar a sua viabilidade como materiais de revestimento. Estudos de resistência à tração, grau de intumescimento, solubilidade, grau de biodegradação, no infravermelho por transformada de Fourier (FTIR), de calorimetria diferencial de varredura (DSC) e de microscopia eletrônica de varredura (SEM) mostraram que o filme compósito se formou quando a quitosana e a gelatina reagiram entre si. Os resultados mostraram que a mistura de proporção ótima foi de 6:4 de quitosana:gelatina. Resultados da liberação do fármaco in vitro indicaram que o sistema de revestimento de Eudragit e bicamada de quitosana/gelatina impediu a liberação de fármaco em fluido intestinal simulado (SIF) e em fluido gástrico simulado (SGF). Entretanto, a liberação de fármaco do comprimido revestido em bicamada no SCF aumentou ao longo do tempo e o fármaco foi quase completamente liberado após 24 h. Em geral, se obteve a forma de liberação dirigida ao cólon, utilizando filme complexo de quitosana/gelatina e sistema de revestimento multicamada.Unitermos: Quitosana/filme de complexo de gelatina. Quitosana/sistema multicamadas de revestimento/ revestimento de fármacos. Fármacos/sistema de liberação/dirigido ao cólon. Comprimidos/revestidos com bicamada.

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Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats

Cited by 175 publications

References 21 publications

Quitosana: biopolímero funcional com potencial industrial biomédico

Quitosana: biopolímero funcional com potencial industrial biomédico

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

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