Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren, Yachao; Jiang, Lei; Yang, Shuman; Gao, Sainan; Yu, Hao; Hu, Jie; Hu, Dandan; Mao, Wenbin; Peng, Haisheng; Zhou, Yulong

doi:10.1590/s2175-97902017000115009

Cited by 15 publications

(9 citation statements)

References 42 publications

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“…The FTIR spectra of C-JFMs showed a strong peak between 3437–3421 cm −1 attributed to OH stretching and the hydrogen bridges of microcapsules by calcium ions ( Figure S1 ) [ 49 ]. The strong peak exists between 2926–2924 cm −1 and 1739–1734 cm −1 confirmed the presence of asymmetric C–H stretching, symmetric–CH stretching, and carbonyl group [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Hartini

Ponrasu

et al. 2021

Polymers

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Microencapsulation of curcumin in jelly fig pectin was performed by the vacuum spray drying (VSD) technique. The VSD was advanced with a low inlet temperature of 80–90 °C and low pressure of 0.01 mPa. By the in situ cross-linking with multivalent calcium ions, jelly fig pectin produced stable curcumin encapsulated microparticles. The physiochemical characteristics of microparticles were thoroughly investigated. The results revealed that 0.75 w/w% of jelly fig pectin and inlet temperature of 90 °C could be feasible for obtaining curcumin microparticles. The VSD technique showed the best encapsulation efficiency and yield and loading efficiency was up to 91.56 ± 0.80%, 70.02 ± 1.96%, and 5.45 ± 0.14%, respectively. The curcumin was readily released into simulated gastrointestinal fluid with 95.34 ± 0.78% cumulative release in 24 h. The antioxidant activity was stable after being stored for six months and stored as a solution for seven days at room temperature before analysis. Hence, the VSD technique could be applicable for the microencapsulation of bioactive compounds such as curcumin to protect and use in the food/pharmaceutical industry.

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Section: Resultsmentioning

confidence: 99%

Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Hartini

Ponrasu

et al. 2021

Polymers

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“…SIF was prepared by mixing 8400 U/L lipase solution in phosphate buffer (pH 7.4). SCF was prepared by adding 6 g/L pectinase solution in phosphate buffer (pH 7.0) [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, tripolyphosphate concentration, and acetic acid concentration as material attributes, stirring speed, and stirring time as process parameters, whereby their influence on two dependent variables such as particle size (PS) and %entrapment efficiency (%EE) was studied. MetNp were synthesized by employing an ionic-gelation technique and optimized formula obtained from the QbD design study. PS and %EE studies revealed the formation of MetNp with 558.06 ± 2.52 nm and 59.07 ± 2.15%, respectively. Furthermore, a Met release study in various simulated gastro-intestinal media suggested pH-triggered (pH > 7.0) and sustained release profile of Met from Eudragit S100 enteric-coated MetNp capsule (MetNp cap). Moreover, the stability investigation of formulations confirmed good stability with respect to their PS and residual drug content (RDC) at different temperature conditions. In conclusion, the QbD method was effectively utilized in the development of MetNp and enteric-coated MetNp cap depicting their potential to release Met through MetNp cap only in the colon region and can be utilized for the treatment of amoebiasis in the colon.

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“…Several approaches including chitosan nanoparticles, liposomal gels, nanoemulsions, positively charged nanoemulsions, microemulsions and cyclodextrin solutions were studied successfully for dermal and transdermal drug delivery of HCN. Some polymer‐based tablets and colon targeted tablets have also been investigated for the oral drug delivery of HCN . Recently, the spray dried solid dispersions have also been studied for the oral bioavailability enhancement of HCN .…”

Section: Introductionmentioning

confidence: 99%

Enhanced Skin Permeation of Hydrocortisone Using Nanoemulsion as Potential Vehicle

et al. 2019

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The current work was performed to estimate the solubility and Hansen solubility parameters of a poorly soluble corticosteroid hydrocortisone (HCN) in various components of nanoemulsion and to enhance the skin permeation rate of HCN using nanoemulsions as potential vehicles. Screening studies suggested the use of Capryol-90 (oil), Triton-X100 (surfactant) and Transcutol-HP (cosurfactant) in the preparation of HCN nanoemulsions. HCN nanoemulsions were developed using low energy emulsification technique and characterized for droplet size, plolydispersity index (PDI), zeta potential (ZP), refractive index (RI), percent of transmittance (% T) and transmission electron microscopy (TEM) and evaluated for drug release behavior. Selected nanoemulsions and control (HCN suspension) were subjected to in vitro skin permeation studies. Optimized formula HSN8 showed droplet size of 52.6 nm, PDI of 0.109, ZP of À 33.72 mV, RI of 1.337 and % T of 97.68%. TEM confirmed spherical-shaped droplets in nanometer range. In vitro drug release evaluation suggested significant release of HCN from optimized nanoemulsion (98.52%) compared with control (35.85%). Skin permeation profile of HCN from optimized nanoemulsion was also significant compared with control. These results suggested the potential of nanoemulsion in enhancing the transdermal delivery of HCN via rat skin.[a] Dr.

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Design and preparation of a novel colon-targeted tablet of hydrocortisone

Cited by 15 publications

References 42 publications

Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Enhanced Skin Permeation of Hydrocortisone Using Nanoemulsion as Potential Vehicle

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