Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88

Hou, Guojun; Zhang, Minyang; Wang, Jing; Zhu, Weiyun

doi:10.1007/s00253-021-11496-4

Cited by 15 publications

(11 citation statements)

References 63 publications

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“…Similarly, an insect-based diet modulated gut microbiota composition and SCFA production by increasing propionate and butyrate in the ceca of laying hens (Borrelli et al, 2017). Additionally, in weaned piglets, chitosan-chelated zinc modulated ileal microbiota and microbial metabolites propionate, butyrate, and lactate (Hou et al, 2021). In contrast, there is still a lack of knowledge surrounding the importance and functionality of the gut microbiota in fish nutrition (Lokesh et al, 2022).…”

Section: Accessibilitymentioning

confidence: 99%

Potential of shrimp waste meal and insect exuviae as sustainable sources of chitin for fish feeds

Rimoldi

Ceccotti

Brambilla³

et al. 2023

Aquaculture

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Section: Accessibilitymentioning

confidence: 99%

Potential of shrimp waste meal and insect exuviae as sustainable sources of chitin for fish feeds

Rimoldi

Ceccotti

Brambilla³

et al. 2023

Aquaculture

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“…The results showed that the piglets treated with a 100 mg zinc and 766 mg chitosan/kg basal diet had significantly increased ileal villus height and ratio of villi height to crypt depth. The administration of chitosan-chelated zinc increased the abundance of Lactobacillus and significantly decreased the abundance of Streptococcus , Escherichia-shigella , Actinobacillus , and Clostridium sensu stricto 6 in the ileal digesta, indicating the ability of chitosan to modulate the composition of gut microbiota and maintain the function of the intestine [ 101 ]. In C57/BL6 mice with azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colorectal cancer (CRC), intragastrical administration of 300 mg/kg/day COS exhibited antitumor activity via reversing the imbalance of bacteria and fungi, especially by reducing the abundance of Escherichia-Shigella , Enterococcus , and Turicibacter , as well as increasing the levels of Akkermansia , Cladosporium , and butyrate-producing bacteria [ 102 ].…”

Section: The Modulation Of the Gut Microbiota By Chitosan And Cosmentioning

confidence: 99%

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

Guan

Feng

2022

IJMS

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Biodegradable chitin is the second-most abundant natural polysaccharide, widely existing in the exoskeletons of crabs, shrimps, insects, and the cell walls of fungi. Chitosan and chitooligosaccharide (COS, also named chitosan oligosaccharide) are the two most important deacetylated derivatives of chitin. Compared with chitin, chitosan and COS not only have more satisfactory physicochemical properties but also exhibit additional biological activities, which cause them to be widely applied in the fields of food, medicine, and agriculture. Additionally, due to their significant ability to improve gut microbiota, chitosan and COS are deemed prospective prebiotics. Here, we introduced the production, physicochemical properties, applications, and pharmacokinetic characteristics of chitosan and COS. Furthermore, we summarized the latest research on their antioxidant, anti-inflammatory, and antimicrobial activities. Research progress on the prebiotic functions of chitosan and COS is particularly reviewed. We creatively analyzed and discussed the mechanisms and correlations underlying these activities of chitosan and COS and their physicochemical properties. Our work enriched people’s understanding of these non-plant-derived prebiotics. Based on this review, the future directions of research on chitosan and COS are explored. Collectively, optimizing the production technology of chitin derivatives and enriching understanding of their biological functions will shed more light on their capability to improve human health.

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“…A higher abundance of Lactobacillus was observed in the ileal digesta, while the abundance of Streptococcus , Escherichia shigella , Actinobacillus , and Clostridium sensu stricto 6 was significantly decreased in chitosan-chelated zinc group piglets. These results illustrate that CS-Zn treatment could help regulate the composition of ileal flora and improve ileal health [ 62 ]. Overall, evidence of the efficacy of physiological zinc supplementation in promoting a healthy supportive effect of normal gut microbiota seems to be growing.…”

Section: Discussionmentioning

confidence: 96%

The Effect of Quadruple Therapy with Polaprezinc or Bismuth on Gut Microbiota after Helicobacter pylori Eradication: A Randomized Controlled Trial

et al. 2022

JCM

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Background: Quadruple therapy with polaprezinc provided an alternative to Helicobacter pylori eradication; however, the effect on gut microbiota remains uncertain. This study aims to identify whether polaprezinc-containing quadruple therapy causes adverse microbiota effects among asymptomatic adults, compared with bismuth therapy. Methods: This was a randomized control trial. One hundred asymptomatic H. pylori-infected adults were randomly (1:1) assigned to two treatment groups (polaprezinc-containing therapy, PQT; or bismuth-containing therapy, BQT). Fecal samples were collected from subjects before and 4–8 weeks after therapy. Samples were sequenced for the V4 regions of the 16S rRNA gene. Results: The relative abundance of the three dominant bacterial phyla (Bacteroidota, Firmicutes, and Proteobacteria) accounted for more than 95% of each treatment group. The alpha diversity between eradications that succeeded and those that failed had no significant difference (p > 0.05). After successful eradication, the alpha diversity in the BQT group decreased in comparison with the baseline (p < 0.05). Subjects who were successfully eradicated by BQT showed considerably lower alpha diversity indices than those of the PQT at follow-up (p < 0.05). The abundance of Parasutterella in subjects who were successfully eradicated by PQT was four times greater than that of BQT (q < 0.05). Conclusion: A 14-day PQT may be superior to BQT in maintaining short-term gut microbiota homeostasis after H. pylori treatment. Our findings preliminarily provide evidence of the short-term impacts of the gut microbiota after PQT treatment of H. pylori infection.

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Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88

Cited by 15 publications

References 63 publications

Potential of shrimp waste meal and insect exuviae as sustainable sources of chitin for fish feeds

Potential of shrimp waste meal and insect exuviae as sustainable sources of chitin for fish feeds

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

The Effect of Quadruple Therapy with Polaprezinc or Bismuth on Gut Microbiota after Helicobacter pylori Eradication: A Randomized Controlled Trial

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