Chitosan-Clay Based (CS-NaBNT) Biodegradable Nanocomposite Films for Potential Utility in Food and Environment

Laaraibi, Asmae; Moughaoui, Fatiha; Damiri, Fouad; Ouakit, Amine; Charhouf, I.; Hamdouch, Souad; Jaafari, A.; AbdelmjidAbourriche,; Knouzi, Noureddine; Bennamara, A.; Berrada, M.

doi:10.5772/intechopen.76498

Cited by 12 publications

(13 citation statements)

References 32 publications

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“…e absorption peaks in the range 900-1200 cm −1 are due to the antisymmetric C-O stretching of the saccharide structure of chitosan [42]. Figure 10 shows the FTIR spectra of lyophilized chitosan salt obtained from solutions of chitosan (acetic acid).…”

Section: Fourier-transform Infrared (Ftir) Spectramentioning

confidence: 99%

Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release

Damiri

Bachra

Bounacir

et al. 2020

Journal of Chemistry

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In this study, chitosan-based hydrogels were produced by incorporating three drugs with a different solubility into a polymer matrix. The lyophilized chitosan salt was prepared using an innovative and less-expensive synthetic process by the freeze-drying technique. Firstly, the three drugs (caffeine, ascorbic acid, and 5-fluorouracil (5-FU)) were selected as model drugs to test the in vitro release behavior of the hydrogel. The drugs were solubilized in chitosan salt, lyophilized, and cross-linked with benzaldehyde involving the formation of a Schiff base with (–C=N-) linkage to produce a physical hydrogel. Subsequently, the physicochemical properties of N-benzyl chitosan and lyophilized chitosan salt were evaluated by Fourier-transform infrared (FTIR) spectra, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The intrinsic viscosity of the conventional chitosan was determined by the Mark–Houwink–Sakurada equation. Moreover, the kinetics of hydrogel swelling and drug release were studied by the UV-visible method at physiological conditions (pH = 7.4 at 37°C). The results show that lyophilized N-benzyl chitosan had a maximum swelling ratio of 720 ± 2% by immersion in phosphate-buffered saline solutions (PBS) (pH = 7.4 at 37°C). In vitro drug releases were evaluated in PBS, and the obtained results show that the maximum drug release after 24 h was 42% for caffeine, 99% for 5-FU, and 94% for ascorbic acid. Then, to optimize the cumulative release of caffeine, Tween 20 was added and 98% as a release percentage was obtained. The drug-loading results were investigated with the Korsmeyer–Peppas kinetic model and applied to determine the drug release mechanism.

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Section: Fourier-transform Infrared (Ftir) Spectramentioning

confidence: 99%

Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release

Damiri

Bachra

Bounacir

et al. 2020

Journal of Chemistry

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“…Chitosan is a marine polysaccharide extracted from chitin [103,126,127]. Naturally, it is found in the cell wall of fungi.…”

Section: Chitin and Chitosan(cs)-based Mnsmentioning

confidence: 99%

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

et al. 2022

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In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams. However, microneedles (MNs) (or microneedle arrays) are low-invasive 3D biomedical constructs that bypass the skin barrier and produce systemic and localized pharmacological effects. In the past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used to manufacture microneedles (MNs). Due to their wide range of functional groups, carbohydrates enable the design and development of tunable properties and functionalities. In recent years, numerous microneedle products have emerged on the market, although much research needs to be undertaken to overcome the various challenges before the successful introduction of microneedles into the market. As a result, carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution. In this review, a comprehensive overview of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose and starch is discussed systematically. It also discusses the various drug delivery strategies and mechanical properties of biomaterial-based MNs, the progress made so far in the clinical translation of carbohydrate-based MNs, and the promotional opportunities for their commercialization. In conclusion, the article summarizes the future perspectives of carbohydrate-based MNs, which are considered as the new class of topical drug delivery systems.

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“…Many researchers have worked on development of biocomposites containing CS [49][50][51][52][53][54][55] and CaP biomaterials. If the biological properties were improved in some cases, the mechanical properties still not comparable to natural bone.…”

Section: Biocomposites: Chitosan-cap Bioceramicsmentioning

confidence: 99%

Chitosan Based Biocomposites for Hard Tissue Engineering

Dabbarh¹,

Elbakali-Kassimi²,

Berrada³

2021

Chitin and Chitosan - Physicochemical Properties and Industrial Applications [Working Title]

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Bone is the second most transplanted organ, just after blood. It provides structural support, protection for organs and soft tissues. It holds some critical biological processes such as the bone marrow blood forming system. It is responsible for storing and supplying minerals such calcium and phosphate. Bone is a connective tissue formed by two predominant phases: an inorganic phase containing mainly apatitic calcium and phosphate and an organic phase made of fibrous type I collagen. This natural biocomposite has many biological features such osteoconductivity, osteoinductivity, osteogenicity and is subject to a continuous remodeling process through osteoclastic and osteoblastic activities. In biomedical engineering, the restoration of damaged hard tissue with autologous bone is not always possible or even the best option. The development of some safe and low-cost alternatives such as biocomposites that mimic organic and calcified bone materials have shown very good results and offer an alternative to autologous bone implants. However, the mechanical properties of biocomposites still present a big challenge as a hard tissue substitute. This chapter reviews the properties of bone substitute materials chitosan and calcium phosphates, discusses strategies used in the treatment of calcified hard tissues as well as new approaches developed in this field.

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Chitosan-Clay Based (CS-NaBNT) Biodegradable Nanocomposite Films for Potential Utility in Food and Environment

Cited by 12 publications

References 32 publications

Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release

Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

Chitosan Based Biocomposites for Hard Tissue Engineering

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