Chitosan-covered liposomes as a promising drug transporter: nanoscale investigations

Lemaalem, Mohammed; Hadrioui, Nourddine; Saad, El Fassi; Derouiche, A.; Ridouane, H.

doi:10.1039/d0ra08305d

Cited by 17 publications

(7 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, graft density affected the diffusion and arrangement of liposomes, the polymer grafting densities increases and the diffusion coefficients decrease. Studies found that the polymers have a normal diffusion after a short regime of sub‐diffusion, and then move freely and increase the dynamic flexibility of the liposomes (Lemaalem et al, 2020; Mohammed et al, 2021).…”

Section: Characteristics Of Polysaccharide‐coated Liposomal Drug Deli...mentioning

confidence: 99%

Polysaccharide‐modified liposomes and their application in cancer research

Peng

Chen²,

Wang

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

Nanodrug delivery systems have been widely used in cancer treatment. Among these, liposomal drug carriers have gained considerable attention due to their biocompatibility, biodegradability, and low toxicity. However, conventional liposomes have several shortcomings, such as poor stability, rapid clearance, aggregation, fusion, degradation, hydrolysis, and oxidation of phospholipids. Polysaccharides are natural polymers of biological origin that exhibit structural stability, excellent biocompatibility and biodegradability, flexibility, non‐immunogenicity, low toxicity, and targetability. Therefore, they represent a promising class of polymers for the modification of the surface properties of liposomes to overcome their shortcomings. In addition, polysaccharides can be readily combined with other materials to develop new composite materials. Hence, they represent the optimal choice for liposomal modification to improve pharmacokinetics and clinical utility. Polysaccharide‐coated liposomes exhibit better stability, drug release kinetics, and cellular uptake than conventional liposomes. The oncologic application of polysaccharide‐coated liposomes has become a research hotspot. We summarize the preparation, physicochemical properties, and antineoplastic effects of polysaccharide‐coated liposomes to facilitate antitumor drug development.

show abstract

Section: Characteristics Of Polysaccharide‐coated Liposomal Drug Deli...mentioning

confidence: 99%

Polysaccharide‐modified liposomes and their application in cancer research

Peng

Chen²,

Wang

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

“…The energyminimised systems further undergo a constant enthalpy (NPH) simulation for 2000 fs using a Langevin thermostat at the desired temperature. This step is used to expedite the process of equilibration [50,56]. Following that, the system is further equilibrated under NPT conditions where Nosé-Hoover thermostat and corresponding barostat are applied to maintain temperature and pressure, respectively.…”

Section: Simulation Detailsmentioning

confidence: 99%

Dilute viscoelastic polymer solutions for dielectric heat transfer applications: A molecular dynamics study

Ravikumar¹,

Karathanassis²,

Smith³

et al. 2023

International Journal of Thermofluids

View full text Add to dashboard Cite

“…CS and related derivatives may have significant impact on the secondary structure of keratin, increase the water content in the SC, reduce the potential of the human immortalized keratinocyte cell membrane and increase its fluidity. Such liposomal complexes with CS are called chitosomes [218]. CS can interact with the negatively charged liposome by an electrostatic mechanism due to the CS positive charge.…”

Section: Chitosomesmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

View full text Add to dashboard Cite

This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

show abstract

Chitosan-covered liposomes as a promising drug transporter: nanoscale investigations

Abstract: In this paper, we studied the graft chitosan conformation and its influence on the liposome membrane structure and dynamics as a function of the grafting molar-fraction.

Cited by 17 publications

References 82 publications

Polysaccharide‐modified liposomes and their application in cancer research

Polysaccharide‐modified liposomes and their application in cancer research

Dilute viscoelastic polymer solutions for dielectric heat transfer applications: A molecular dynamics study

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Contact Info

Product

Resources

About