Chitosan facilitates structure formation of the salivary gland by regulating the basement membrane components

Yang, Ting‐Hua; Hsiao, Ya‐Chuan

doi:10.1016/j.biomaterials.2015.06.028

Cited by 30 publications

(26 citation statements)

References 59 publications

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“…Available biomaterials that support branching morphogenesis of embryonic salivary glands include PVDF, 66 chitosan, 67, 68 alginate gel, 69 fibrous PLGA scaffold, 26 and polyacrylamide gel. 16 For alginate and polyacrylamide gels, surface conjugation with a cell adhesive peptide (RGD) or fibronectin is necessary to improve cell/tissue adhesion.…”

Section: Biomaterials Strategymentioning

confidence: 99%

Biomaterials-based strategies for salivary gland tissue regeneration

et al. 2016

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The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to harvest the regenerative potential of stem/progenitor cells found in the adult glands and combine them with biomimetic and cell-instructive materials to assemble implantable tissue modules.

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Section: Biomaterials Strategymentioning

confidence: 99%

Biomaterials-based strategies for salivary gland tissue regeneration

et al. 2016

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“…This manuscript version is made available under the Elsevier user license http://www.elsevier.com/open-access/userlicense/1.0/ of these coatings, chitosan consists of a large number of hydroxy and amino groups, and possesses outstanding properties, such as non-toxicity, biodegradability and biocompatibility [4][5][6]. The above advantages make the chitosan-based material has been widely used in the field of tissue engineering [7][8]. However, its application is limited due to the hydrophobic property and common bacterial infection after surgery.…”

Section: Introductionmentioning

confidence: 99%

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Yang

et al. 2017

International Journal of Biological Macromolecules

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Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications.

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“…To prevent this risk, the surfaces of these implants are usually protected by a bioactive coating [2][3][4][5][6]. Among these coating materials, chitosan possesses outstanding properties, such as non-toxicity, biodegradability, biocompatibility, and antimicrobial [7][8][9][10][11]. As one of the most abundant polysaccharides in crustacean exoskeletons and is commonly found in the cell walls of several fungi and algae, chitosan consists of a large number of hydroxy and amino groups [12].…”

Section: Introductionmentioning

confidence: 99%

Chemical modification of chitosan film via surface grafting of citric acid molecular to promote the biomineralization

Liu

Shen

Zhou

et al. 2016

Applied Surface Science

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We develop a novel chitosan-citric acid film (abbreviated as CS-CA) suitable for biomedical applications in this study. In this CS-CA film, the citric acid, which is a harmless organic acid has been extensively investigated as a modifying agent on carbohydrate polymers, was cross-linked by 1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) onto the surface of chitosan (CS) film. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) confirms the graft copolymerization of the modified chitosan film (CS-CA). Surface wettability, moisturizing performance, the capacity of mineralization in vitro and biocompatibility of the films were characterized. After modification, this CS-CA film has good hydrophilicity. It is very evident that the citric acid grafting treatment significantly promotes the biomineralization of the chitosan based substrates. Cell experiments show that the MC3T3-E1 osteoblasts can adhere and proliferate well on the surface of CS-CA film. This CS-CA film, which can be prepared in large quantities and at low cost, should have potential application in bone tissue engineering.

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Chitosan facilitates structure formation of the salivary gland by regulating the basement membrane components

Cited by 30 publications

References 59 publications

Biomaterials-based strategies for salivary gland tissue regeneration

Biomaterials-based strategies for salivary gland tissue regeneration

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Chemical modification of chitosan film via surface grafting of citric acid molecular to promote the biomineralization

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