Chitosan for the delivery of antibiotics

Harris, Michael A.; Alexander, Christopher; Wells, Carlos M.; Bumgardner, Joel D.; Carpenter, Daniel; Jennings, Jessica Amber

doi:10.1016/b978-0-08-100228-5.00006-7

Cited by 12 publications

(4 citation statements)

References 137 publications

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“…Chitosan nanoparticles are synthesized for different purposes by various methods, such as ionotropic gelation, polyelectrolyte complexation, emulsification solvent diffusion, microemulsion, and reverse micelle formation [ 204 , 205 ]. Moreover, the antimicrobial effects of chitosan-based nanoparticles for drug and drug-free delivery systems have been intensively investigated against bacteria and fungi [ 56 , 57 , 58 , 60 , 63 , 67 , 68 , 106 , 119 , 203 , 206 , 207 , 208 , 209 , 210 , 211 , 212 ]. For example, chitosans of different DDAs and MWs exhibited synergistic activity with sulfamethoxazole against P. aeruginosa [ 213 ].…”

Section: Applications Of Chitosan-based Nanoparticles and Films Inmentioning

confidence: 99%

Antimicrobial Actions and Applications of Chitosan

et al. 2021

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Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism. In this review article, the fundamental properties, modes of antimicrobial action, and antimicrobial effects-related factors of chitosan are discussed. We further summarize how microorganisms genetically respond to chitosan. Finally, applications of chitosan-based biomaterials, such as nanoparticles and films, in combination with current clinical antibiotics or antifungal drugs, are also addressed.

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Section: Applications Of Chitosan-based Nanoparticles and Films Inmentioning

confidence: 99%

Antimicrobial Actions and Applications of Chitosan

et al. 2021

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“…In this regard, CA electrospun NFs have indicated striking properties to dermal/transdermal or wound dressing applications [9,23]. Moreover, CS NPs have brought great bene ts for the loading/delivery of therapeutics agents and wound dressing materials due to its unique physicochemical and inherent antibacterial properties [41][42][43]. Herein, we attempt to present the bene ts of CA NFs concurrent with the therapeutic effects of CS NPs to delivery of Ery for enhancing antibacterial wound healing applications.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

Doostan

Maleki

Doostan

et al. 2020

Preprint

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This study attempts to fabricate the antibacterial nanofibrous mats composed of cellulose acetate (CA) nanofibers loaded with erythromycin-chitosan nanoparticles (Ery-CS NPs) intended for infected wound dressing. The Ery-loaded CS NPs were prepared by ionic gelation process and then incorporated into the CA electrospun nanofibers (NFs). The characterization of the NPs and mats were investigated by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) to show the size distribution, morphology and surface chemistry along with other physiochemical properties including hydrophilicity property, porosity, and water absorption capacity. The antimicrobial activity and cell viability of fibroblast cells were also evaluated. The results indicated that Ery was loaded into CS NPs with high encapsulation efficiency (95%). The CA NFs (17%) incorporated with the Ery-CS NPs (12 wt%) displayed smooth homogenous morphology with 141.7 ± 91.7 nm average diameter. The relevant analyses revealed that the NPs incorporated in NFs and provided high water holding capacity with high porosity. Finally, Ery-CS NPs/CA mats were able to inhibit the growth of both Gram-positive and Gram-negative bacteria as well as showed no cytotoxic effect on the human dermal fibroblast cells. Overall, our findings concluded that the proposed system could be potentially applied as the proper antibacterial mats for infected wound dressing applications.

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“…Chemical modification is a powerful tool to enhance drug load capability, to control polymer-drug interaction, and to improve CS bulk properties to prepare sustained drug release systems. The hydroxyl and amine groups of CS allow to attach CS coatings to different materials as well as to form antimicrobial derivatives [27]. Moreover, the antioxidant activity of CS and its derivatives is attributed to its ability to easily abstract hydrogen atoms from free radicals.…”

Section: Cs Production and Modificationsmentioning

confidence: 99%

Chitosan Applications on Pharmaceutical Sciences: A Review

Villegas

Cid

Romero

et al. 2019

DDL

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Background: Chitosan (CS) is a biomaterial derived from chitin, known for its excellent biological properties. One of the most interesting features of CS is its potential for chemical derivatization, which makes it a versatile material and allows to expand its applications. In the last years, the interest on this polymer and its pharmaceutical applications has notably increased. This biopolymer is being widely studied for its interesting properties, such as bioadhesion, antimicrobial activity, biocompatibility, and biodegradability. Other promising properties of CS include its modulation of immunological response, hemostasis, and wound and bone healing activity. Objective: In this work, a critical review is performed covering its conventional and novel applications, specially focused on pharmaceutical area, providing a clear picture of the current state of art to serve as a basis to direct future research in this field. Conclusion: Despite all the qualities of this polymer, there are only few CS-based products in the market, so it is a priority to enhance the research to develop new technologies and CS-based systems to enforce this biopolymer in the industry.

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Chitosan for the delivery of antibiotics

Cited by 12 publications

References 137 publications

Antimicrobial Actions and Applications of Chitosan

Antimicrobial Actions and Applications of Chitosan

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

Chitosan Applications on Pharmaceutical Sciences: A Review

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