Chitosan/gelatin porous scaffolds assembled with conductive poly(3,4-ethylenedioxythiophene) nanoparticles for neural tissue engineering

Abstract

An electrically conductive scaffold was prepared by assembling PEDOT on a chitosan/gelatin porous scaffold via in situ interfacial polymerization.

Highly Conductive, Stretchable, and Cell‐Adhesive Hydrogel by Nanoclay Doping

“…To our knowledge, this is the first report of the use of a nanoclay for doping of conductive polymers. The conductivity (four‐probe) of PEDOT:Laponite–PAAM hydrogels is among some of the highest reported for PEDOT‐containing hydrogels . The percolating scaffold of Laponite nanocrystals in our system ensures PEDOT forms a continuous conductive network.…”

“…Hydrogels are, however, intrinsically nonelectroconductive. Some promising strategies for their electrical functionalization rely on incorporating conductive polymers such as poly(3,4‐ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS), polyaniline, or polypyrrole . Recently, gelation of aqueous emulsions of PEDOT:PSS nanoparticles using ionic liquids has been reported to produce highly conductive hydrogels that have been integrated in cuff‐type sciatic nerve implants in mice .…”

From Dermal Patch to Implants—Applications of Biocomposites in Living Tissues

“…Also in the field of neural tissue engineering, Wang et al [70] developed a conductive scaffold composed of chitosan, gelatin and poly(3,4-ethylene-dioxythiophene) (PEDOT) nanoparticles. Chitosan/gelatin porous scaffolds were immersed in a solution containing ammonium persulfate (APS) and EDOT monomer, as illustrated in Figure 5b.…”

“…Nanohydroxyapatite and glycol chitosan [10] Hydroxyapatite and polymeric blend (fibroin, chitosan and agarose) [11] Calcium silicate, zinc silicate and graphene oxide [15] Collagen, silk fibroin and dECM [26] Boron nitride and boron trioxide [28] Nanohydroxyapatite, calcium sulfate and bioactive molecules [32] Orthopedic Implants PEEK and graphene oxide [39] CFRPEEK, nanohydroxyapatite, carboxymethyl, chitosan and bone forming peptide [41] Polyphenylene sulfide and nanohydroxyapatite [42] Polyimide and tantalum pentaoxide [43] Hydroxyapatite, ceria nanoparticles and silver nanoparticles [44] Wound Healing Polycaprolactone and gelatin [54] Chitosan, polyethylene oxide and fibrinogen [57] Collagen, alginate and silver nanoparticles [60] Polyurethane, keratin and silver nanoparticles [63] Collagen and dextran [65] Tissue Engineering Fibrin, alginate and genipin [68] PEDOT, chitosan and gelatin [70] Polycaprolactone, silk fibroin and carbon nanotubes [71] Silk fibroin and melanin [78] Polycaprolactone and collagen [82] Gelatin, alginate and fibrinogen [88] Collagen type I and gelatin methacryloyl [89] Author Contributions: Conceptualization, K.P.V., A.B., and A.S.; writing-original draft preparation, K.P.V. ; writing-review and editing, K.P.V., A.B., and A.S.; supervision, A.B.…”

“…(b) Schematic of the synthetic route to the PEDOT/Chitosan/Gelatin scaffold. Reprinted with permission from Reference[70]. (c) Design of nanofiber yarns network embedded in hydrogel to create 3D scaffold.…”