“…An intense band that split into two peaks at 629 and 582 cm −1 present in the spectra of MNPs corresponds to Fe–O bending vibrations 15 . Coating of SiO 2 onto Fe 3 O 4 MNPs was confirmed by the presence of a strong and broad stretching vibration band of the siloxane groups at 1085 cm −1 16 . Grafting of chitosan onto MNPs was confirmed by the bands at 1098, 1387, and 2925 cm −1 which are assigned to C–O, C–N, and C–H stretching vibrations respectively 20,21 .…”
Section: Resultsmentioning
confidence: 92%
“…Silica‐coated Fe 3 O 4 nanoparticles were prepared by sol–gel process according to previously reported method 16 . Fe 3 O 4 MNPs (1 g) was dispersed in a mixture of deionized water (225 ml) and EtOH (60 ml) by sonication for 1 h. Then 5 ml of ammonia aqueous solution (20%) and TEOS (1 ml) were added to the mixture at room temperature for and stirred for 12 h to achieve core–shell MNPs (SiO 2 @Fe 3 O 4 MNPs).…”
Silymarin (SIL) contains a various flavonolignans extracted from Silybum marianum and has an anti-cancer properties against a variety of cancers. In this study, two types of improved nanocarriers based on iron oxide magnetic nanoparticles (MNPs) including chitosan anchored onto silica coated and uncoated Fe 3 O 4 MNPs (Cs-f-SiO 2 @Fe 3 O 4 MNPs and Cs-f-Fe 3 O 4 MNPs) were successfully fabricated and characterized. Next, silymarin was loaded into the nanocarriers (SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs and SIL-Cs-f-Fe 3 O 4 MNPs). These systems were characterized and silymarin content, antioxidant activity and intrinsic cytotoxicity were assessed. The functionalization degree of silymarin was assessed by the Folin-Ciocalteu method, finding 120 mg of SIL/g of Cs-f-SiO 2 @Fe 3 O 4 MNPs and 99 mg of SIL/g of Cs-MNPs. The antioxidant activity of the silymarin after loading into Cs-f-SiO 2 @Fe 3 O 4 MNPs and Cs-f-Fe 3 O 4 MNPs was proved by DPPH method. These compounds have high antioxidant effect and their radical scavenging activity increased with increasing these concentrations. SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs showed higher antioxidant activity than the SIL-Cs-f-Fe 3 O 4 MNPs in same concentrations. The cytotoxicity of Cs-f-SiO 2 @Fe 3 O 4 MNPs and SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs against MCF-7 was investigated by MTT assay and IC50 values were 110.03 and 73.56 μgml À1 respectively. In conclusion, SIL-loaded MNPs can be used as drug delivery system on target in the treatment of cancer cells.
“…An intense band that split into two peaks at 629 and 582 cm −1 present in the spectra of MNPs corresponds to Fe–O bending vibrations 15 . Coating of SiO 2 onto Fe 3 O 4 MNPs was confirmed by the presence of a strong and broad stretching vibration band of the siloxane groups at 1085 cm −1 16 . Grafting of chitosan onto MNPs was confirmed by the bands at 1098, 1387, and 2925 cm −1 which are assigned to C–O, C–N, and C–H stretching vibrations respectively 20,21 .…”
Section: Resultsmentioning
confidence: 92%
“…Silica‐coated Fe 3 O 4 nanoparticles were prepared by sol–gel process according to previously reported method 16 . Fe 3 O 4 MNPs (1 g) was dispersed in a mixture of deionized water (225 ml) and EtOH (60 ml) by sonication for 1 h. Then 5 ml of ammonia aqueous solution (20%) and TEOS (1 ml) were added to the mixture at room temperature for and stirred for 12 h to achieve core–shell MNPs (SiO 2 @Fe 3 O 4 MNPs).…”
Silymarin (SIL) contains a various flavonolignans extracted from Silybum marianum and has an anti-cancer properties against a variety of cancers. In this study, two types of improved nanocarriers based on iron oxide magnetic nanoparticles (MNPs) including chitosan anchored onto silica coated and uncoated Fe 3 O 4 MNPs (Cs-f-SiO 2 @Fe 3 O 4 MNPs and Cs-f-Fe 3 O 4 MNPs) were successfully fabricated and characterized. Next, silymarin was loaded into the nanocarriers (SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs and SIL-Cs-f-Fe 3 O 4 MNPs). These systems were characterized and silymarin content, antioxidant activity and intrinsic cytotoxicity were assessed. The functionalization degree of silymarin was assessed by the Folin-Ciocalteu method, finding 120 mg of SIL/g of Cs-f-SiO 2 @Fe 3 O 4 MNPs and 99 mg of SIL/g of Cs-MNPs. The antioxidant activity of the silymarin after loading into Cs-f-SiO 2 @Fe 3 O 4 MNPs and Cs-f-Fe 3 O 4 MNPs was proved by DPPH method. These compounds have high antioxidant effect and their radical scavenging activity increased with increasing these concentrations. SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs showed higher antioxidant activity than the SIL-Cs-f-Fe 3 O 4 MNPs in same concentrations. The cytotoxicity of Cs-f-SiO 2 @Fe 3 O 4 MNPs and SIL-Cs-f-SiO 2 @Fe 3 O 4 MNPs against MCF-7 was investigated by MTT assay and IC50 values were 110.03 and 73.56 μgml À1 respectively. In conclusion, SIL-loaded MNPs can be used as drug delivery system on target in the treatment of cancer cells.
“…In addition, the higher adsorption capacity (52.14 mg/g) was recorded at pH 12 which might be due to the electrostatic interaction ( Fig. 8 b ) ( Danalıoğlu et al, 2018 ). Fig.…”
Section: Antibiotics Removal By Chitosan Composites-based Adsorbentsmentioning
confidence: 98%
“…pH Ref. MCsGO CIP 282.9 4-9 ( Wang et al, 2016 ) MACCs CIP 90.01 — ( Danalıoğlu et al, 2017 ) MgO/Cs/GO CIP 1111 7 ( Nazraz et al, 2019 ) Fe-CS NCs CIP 142.85 6 ( Rasoulzadeh et al, 2019 ) Cs/BC CIP >76 3 ( Afzal et al, 2018 ) CoFe 2 O 4 /AC@Cs CIP 188.68 5 ( Malakootian et al, 2018 ) Cs/kaolin/Fe 3 O 4 CIP 47.85 6 ( Ma et al, 2014 ) Cs-grafted SiO 2 /Fe 3 O 4 CIP 100.74 12 ( Danalıoğlu et al, 2018 ) Zn(II)–Impregnated Cs/GO CIP 210.96 6.5 ( Rahman and Varshney 2021 ) Cs-EDTA-β-CD CIP 49.37 4-6 ( Zhao et al, 2017 ) Humic acid/BC@Cs CIP 153.00 8 ( Afzal et al, 2019 ) …”
Section: Antibiotics Removal By Chitosan Composites-based Adsorbentsmentioning
confidence: 99%
“… Fig. 8 BET of (a) Cs, SiO 2 /Fe 3 O 4 and Cs-grafted SiO 2 /Fe 3 O 4 and (b) effect of pH on the adsorption of CIP onto Cs-grafted SiO 2 /Fe 3 O 4 ( Danalıoğlu et al, 2018 ). Copyright, Elsevier, 2021.…”
Section: Antibiotics Removal By Chitosan Composites-based Adsorbentsmentioning
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