Chitosan/HPMC Polymer Blends for Developing Transdermal Drug Delivery Systems

Siddaramaiah,; Kumar, Pramod; Divya, K.; Mhemavathi, B. T.; Manjula, D.

doi:10.1080/10601320600575231

Cited by 29 publications

(14 citation statements)

References 9 publications

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“…Owing to their biodegradability and bioactivity, homopolymers and copolymers of chitosan have been widely used in packaging material applications (Arvanitoyannis, Nakayama, & Aiba, 1998;Coma, 2008;Coma et al, 2002;Fimbeau, Grelier, Copinet, & Coma, 2005;Möller, Grelier, Pardon, & Coma, 2004). In parallel, there is an increased interest in preparing chitosan/polymer blends for different applications, such as biomaterial applications (Arvanitoyannis, Kolokuris, Nakayama, Yamamoto, & Aiba, 1997;Luo, Yin, Khutoryanskaya, & Khutoryanskiy, 2008;Molinaro, Leroux, Damas, & Adam, 2002;Park et al, 2001;Siddaramaiah, Divya, Mhemavathi, & Manjula, 2006;Zhao, Mitomo, & Yosh, 2008). The presence of amino groups makes chitosan soluble in dilute aqueous solutions of common acids.…”

Section: Introductionmentioning

confidence: 96%

Chitosan, sisal cellulose, and biocomposite chitosan/sisal cellulose films prepared from thiourea/NaOH aqueous solution

Almeida¹,

Frollini²,

Castellan³

et al. 2010

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 96%

Chitosan, sisal cellulose, and biocomposite chitosan/sisal cellulose films prepared from thiourea/NaOH aqueous solution

Almeida¹,

Frollini²,

Castellan³

et al. 2010

Carbohydrate Polymers

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“…The combination of polymers as materials for controlled drug‐delivery applications may offer significant advantages because it allows the adjustment of the mechanical properties of the material, the desired drug‐release pattern, and the drug‐release mechanism of the drug. For example, Siddaramaiah et al proposed the use of chitosan and hydroxypropyl methylcellulose blends in different compositions for the delivery of propranolol HCl, and Abd El‐Bary et al used a blend of chitosan with different proportions of poly(vinyl alcohol) to study drug delivery with brilliant blue dye as the model drug.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Pardini

Amalvy

2013

J of Applied Polymer Sci

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Polyurethane (PU)/poly[2‐(diethylamino)ethyl methacrylate] hybrids, having a chemical bond between the PU and acrylic moieties and with different compositions, were prepared by the dispersion polymerization of 2‐(diethylamino)ethyl methacrylate (DEA) in the presence of preformed PU chains with polymerizable terminal vinyl groups. The PU dispersion was synthesized according to a prepolymer mixing process by the polyaddition of isophorone diisocyanate, poly(propylene glycol), 2‐hydroxyethyl methacrylate, and dimethylol propionic acid (DMPA). Then, it was dispersed in water by the prior neutralization of the carboxylic acid groups of DMPA with triethylamine, chain‐extended with ethylenediamine. The effect of the DEA content on the swelling properties (water uptake and dynamic swelling degree) at different pHs and at 37°C was determined. The samples were also characterized by Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. The experimental results indicate a higher water uptake when the DEA content was increased on the hybrid materials and a significant change in the kinetics of swelling at pH 4 compared to those at pH 7. The water content of the hydrogels depended on the DEA content, and it was inversely proportional to the pH value. The pure PU film did not show important changes over the pH range examined in this study. The synthesized hybrids were useful as drug‐delivery, pH‐sensitive matrices. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39799.

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“…Chitosan is the soluble derivative of chitin obtained by Ndeacetylation, which biocompatibility and non-toxicity make it an excellent candidate as a raw material in the biomedical field (Kumar, 2000). Chitosan has been proposed for a range of controlled drug release formulations (Prabaharan and Mano, 2005;Wang et al, 2007), as rate controlling membranes in transdermal delivery systems (Siddaramaiah et al, 2006;Thacharodi and Panduranga Rao, 1996), as a biomaterial (Lopez-Perez et al, 2007;Silva et al, 2004a,b) and for tissue engineering (Baran et al, 2004;Mano and Reis, 2007;Patel et al, 2007;Silva et al, 2007;Tuzlakoglu et al, 2004). We previously developed chitosan membranes that possess adequate permeation properties for the rapid elimination or delivery of small molecules (da Silva et al, accepted).…”

mentioning

confidence: 99%

Poly(N‐isopropylacrylamide) surface‐grafted chitosan membranes as a new substrate for cell sheet engineering and manipulation

Silva

López-Pérez

Elvira

et al. 2008

Biotech & Bioengineering

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The immobilization of poly(N-isopropylacrylamide) (PNIPAAm) on chitosan membranes was performed in order to render membranes with thermo-responsive surface properties. The aim was to create membranes suitable for cell culture and in which confluent cell sheets can be recovered by simply lowering the temperature. The chitosan membranes were immersed in a solution of the monomer that was polymerized via radical initiation. The composition of the polymerization reaction solvent, which was a mixture of a chitosan non-solvent (isopropanol) and a solvent (water), provided a tight control over the chitosan membranes swelling capability. The different swelling ratio, obtained at different solvent composition of the reaction mixture, drives simultaneously the monomer solubility and diffusion into the polymeric matrix, the polymerization reaction rate, as well as the eventual chain transfer to the side substituents of the pyranosyl groups of chitosan. A combined analysis of the modified membranes chemistry by proton nuclear magnetic resonance ((1)H-NMR), Fourier transform spectroscopy with attenuated total reflection (FTIR-ATR) and X-ray photoelectron spectroscopy (XPS) showed that it was possible to control the chitosan modification yield and depth in the solvent composition range between 75% and 100% of isopropanol. Plasma treatment was also applied to the original chitosan membranes in order to improve cell adhesion and proliferation. Chitosan membranes, which had been previously subjected to oxygen plasma treatment, were then modified by means of the previously described methodology. A human fetal lung fibroblast cell line was cultured until confluence on the plasma-treated thermo-responsive chitosan membranes and cell sheets were harvested lowering the temperature.

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Chitosan/HPMC Polymer Blends for Developing Transdermal Drug Delivery Systems

Cited by 29 publications

References 9 publications

Chitosan, sisal cellulose, and biocomposite chitosan/sisal cellulose films prepared from thiourea/NaOH aqueous solution

Chitosan, sisal cellulose, and biocomposite chitosan/sisal cellulose films prepared from thiourea/NaOH aqueous solution

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Poly(N‐isopropylacrylamide) surface‐grafted chitosan membranes as a new substrate for cell sheet engineering and manipulation

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