Chitosan in Surface Modification for Bone Tissue Engineering Applications

Abinaya, Balakrishnan; Prasith, Tandiakkal Prakash; Ashwin, Badrinath; Chandran, S. Viji; Selvamurugan, N.

doi:10.1002/biot.201900171

Cited by 49 publications

(25 citation statements)

References 138 publications

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“…Scaffolds used in bone tissue engineering can be from natural or synthetic polymers or bioceramics. Natural polymers such as collagen [ 8 ], silk [ 9 ], chitosan [ 10 ], and alginate [ 11 ] have been used in bone tissue engineering. These are known to cause a minimal immune reaction, but at the same time, their use is hindered due to reduced mechanical stability [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration

Hassan

Yuvaraju

Galiwango

et al. 2022

JFB

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Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel technique. Sr/Zn n-HAp and poly (lactide-co-glycolide) (PLGA) were used to fabricate composite scaffolds by supercritical carbon dioxide technique. FTIR, XRD, TEM, SEM, and TGA were used to characterize Sr/Zn n-HAp and the composite scaffolds. The synthesized scaffolds were adequately porous with an average pore size range between 189 to 406 µm. The scaffolds demonstrated bioactive behavior by forming crystals when immersed in the simulated body fluid. The scaffolds after immersing in Tris/HCl buffer increased the pH value of the medium, establishing their favorable biodegradable behavior. ICP-MS study for the scaffolds detected the presence of Sr, Ca, and Zn ions in the SBF within the first week, which would augment osseointegration if implanted in the body. nHAp and their composites (PLGA-nHAp) showed ultimate compressive strength ranging between 0.4–19.8 MPa. A 2.5% Sr/Zn substituted nHAp-PLGA composite showed a compressive behavior resembling that of cancellous bone indicating it as a good candidate for cancellous bone substitute.

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Section: Introductionmentioning

confidence: 99%

Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration

Hassan

Yuvaraju

Galiwango

et al. 2022

JFB

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“…SM refers to a process for achieving new surface properties, such as hydrophilicity, biocompatibility and antistatic properties, while maintaining the original properties of materials or products. In recent years, with the good integration of scaffold materials and the improvement of interfacial interactions between materials in scaffolds, SM has been widely studied by researchers and is mainly achieved through physical and chemical methods, such as plasma spraying, flame spraying, microarc oxidation, laser ablation, sol-gel, surface grafting and electrodeposition [262]. In recent years, from the perspective of bone tissue development, anatomy and physiology, biomimetic SM technology has been favoured by a large number of scholars.…”

Section: Interface Reinforcement and Nanotechnologymentioning

confidence: 99%

Biodegradable materials for bone defect repair

et al. 2020

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Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers. In the treatment of bone defects, scaffolds made of biodegradable materials can provide a crawling bridge for new bone tissue in the gap and a platform for cells and growth factors to play a physiological role, which will eventually be degraded and absorbed in the body and be replaced by the new bone tissue. Traditional biodegradable materials include polymers, ceramics and metals, which have been used in bone defect repairing for many years. Although these materials have more or fewer shortcomings, they are still the cornerstone of our development of a new generation of degradable materials. With the rapid development of modern science and technology, in the twenty-first century, more and more kinds of new biodegradable materials emerge in endlessly, such as new intelligent micro-nano materials and cell-based products. At the same time, there are many new fabrication technologies of improving biodegradable materials, such as modular fabrication, 3D and 4D printing, interface reinforcement and nanotechnology. This review will introduce various kinds of biodegradable materials commonly used in bone defect repairing, especially the newly emerging materials and their fabrication technology in recent years, and look forward to the future research direction, hoping to provide researchers in the field with some inspiration and reference.

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“…Although investigators have fabricated a variety of biomaterials that mimic the morphology and functions of natural bone tissue and have verified the effectiveness in promoting bone regeneration at the cellular and animal levels, there are still many obstacles and challenges in the BTE application of modified CS [ 164 , 305 ]. Future implant designs should give an even greater consideration to local cellular responses.…”

Section: Challenges and Future Prospectsmentioning

confidence: 99%

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

Zhu

Zhang

Zhou

2022

IJMS

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In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since bone is such a complex and dynamic structure, the construction of bone tissue composite materials has become an attractive strategy to guide bone growth and regeneration. Chitosan and its derivatives have been promising vehicles for BTE owing to their unique physical and chemical properties. With intrinsic physicochemical characteristics and closeness to the extracellular matrix of bones, chitosan-based composite scaffolds have been proved to be a promising candidate for providing successful bone regeneration and defect repair capacity. Advances in chitosan-based scaffolds for BTE have produced efficient and efficacious bio-properties via material structural design and different modifications. Efforts have been put into the modification of chitosan to overcome its limitations, including insolubility in water, faster depolymerization in the body, and blood incompatibility. Herein, we discuss the various modification methods of chitosan that expand its fields of application, which would pave the way for future applied research in biomedical innovation and regenerative medicine.

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Chitosan in Surface Modification for Bone Tissue Engineering Applications

Cited by 49 publications

References 138 publications

Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration

Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration

Biodegradable materials for bone defect repair

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

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