Chitosan–magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential

Khunawattanakul, Wanwisa; Puttipipatkhachorn, Satit; Rades, Thomas; Pongjanyakul, Thaned

doi:10.1016/j.ijpharm.2007.09.038

Cited by 53 publications

(26 citation statements)

References 21 publications

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“…The decrease in viscosity of the composite dispersion might be caused by a reduction of intra-molecular hydrogen bonding of chitosan and a decrease in hydrogen-bonded hydration of chitosan, while heating did not affect the hydration of magnesium aluminum silicate, because magnesium aluminum silicate dispersions were prepared and hydrated using hot water in the preparation process. [13]…”

Section: Resultsmentioning

confidence: 99%

Rheological behavior and stability of ciprofloxacin suspension: Impact of structural vehicles and flocculating agent

Moghimipour¹,

Rezaee²,

Salimi³

et al. 2013

J Adv Pharm Technol Res

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Ciprofloxacin is a fluoroquinolone and is used against a broad spectrum of gram-negative and gram-positive bacteria. The aim of the study is to investigate the effect of structural vehicles and other formulating factors on physical stability and rheological behavior of ciprofloxacin suspension. To formulate the suspensions, the effect of glycerin and polysorbate 80 as wetting agents was evaluated. Then to achieve controlled flocculation, different concentrations of sodium chloride and calcium chloride were added. After choosing suitable wetting and flocculating agents, structural vehicles such as sodium carboxyl methyl cellulose (NaCMC), hydroxypropylmethylcellulose (HPMC) and Veegum were evaluated. Physical stability parameters such as sedimentation volume, the degree of flocculation and the ease of redispersion of the suspensions and growth of crystals were evaluated. After incorporation of structural vehicles, the rheological properties of formulations containing were also studied to find out their rheological behavior. According to the results, suspension containing glycerin (0.2% w/v) and sodium chloride (0.05% w/v) as wetting agent and flocculating agent, respectively, were the most stable formulations regarding their F and N. Microscopic observations showed the growth of crystals in ciprofloxacin suspension in formulation without excipients and the minimum amount of crystal growth was seen in suspension containing NaCMC (0.25% w/v), Veegum (0.1% w/v) and NaCl (0.05% w/v). Rheological studies showed that almost all of the formulations had psuedoplastic behavior with different degree of thixotropy. The formulation containing NaCMC (0.25% w/v), Veegum (0.1% w/v) and NaCl (0.05% w/v) was the most stable formulation. It may be concluded that by altering the amount ratios of formulation factors, the best rheological behavior and the most proper thixotropy may be achieved.

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Section: Resultsmentioning

confidence: 99%

Rheological behavior and stability of ciprofloxacin suspension: Impact of structural vehicles and flocculating agent

Moghimipour¹,

Rezaee²,

Salimi³

et al. 2013

J Adv Pharm Technol Res

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“…Heat treatment also caused a decrease in viscosity and hysteresis loop of high molecular weights of chitosan-magnesium aluminum silicate dispersion. The decrease in viscosity of the composite dispersion might have been caused by a reduction of intra-molecular hydrogen bonding of chitosan and a decrease in hydrogen-bonded hydration of chitosan, while heating did not affect the hydration of magnesium aluminum silicate, because magnesium aluminum silicate dispersions were prepared and hydrated using hot water in the preparation process (16). Li et al in 2005 reported that hydroxyethyl cellulose in combination with bromododecane increased viscosity and caused thermal stability (17).…”

Section: Discussionmentioning

confidence: 99%

Influence of Flocculating Agents and Structural Vehicles on the Physical Stability and Rheological Behavior of Nitrofurantoin Suspension

Moghimipour

Salimi

Rezaee³

et al. 2014

Jundishapur J Nat Pharm Prod

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Background:Nitrofurantoin is a nitrofuran antibiotic that has been used for treatment of urinary tract against positive and negative bacteria. Objectives: The aim of this study was to evaluate the effect of structural vehicles and flocculating agents on physical stability and rheological behavior of nitrofurantoin suspension. Materials and Methods: To formulate the suspensions, the effect of glycerin and polysorbate 80 as wetting agents was evaluated and their particle sizes were determined using the sieve method. Then to achieve controlled flocculation, sodium citrate and aluminum chloride were added. After choosing the suitable wetting and flocculating agents, structural vehicles such as sodium carboxyl methyl cellulose and Veegum were evaluated individually and in combination. In addition, the effect of sorbitol on density of continuous phase and some physical stability parameters such as sedimentation volume, degree of flocculation and ease of redispersion of the suspensions were evaluated. After incorporation of structural vehicles, the rheological properties of formulations were also determined to find their flow behavior. Results: According to the results, glycerin (0.2%) and sodium citrate (0.3%) had the best effect on the suspension stability as wetting and flocculating agents, respectively. Rheological properties of formulations showed pseudoplastic behavior with some degree of thixotropy. Conclusions: In conclusion, the suspension containing Veegum 1%, sodium carboxy methyl cellulose 1%, glycerine 0.2%, sodium citrate 0.3% and sorbitol 20 % was chosen as the most physically stable formulation.

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“…Inorganic substances such as clays are also commonly employed as gelling agents to alter the viscosity of a formulation. One example is the use of magnesium aluminum silicate, an anionic clay, which can interact with polymers such as sodium alginate and chitosan to change their aqueous flow characteristics [4,5]. Similar to how solid particles are characterized, polymers are described by certain parameters, most notably their molecular weight and morphology.…”

Section: Stokes Equationmentioning

confidence: 99%

Rheology in Pharmaceutical Formulations-A Perspective

Mastropietro¹,

Nimroozi²,

Omidian³

2013

J Dev Drugs

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Medications produced as semi-solids type product such as creams, ointments and lotions are based on emulsion or suspension type systems consisting of two or more incompatible materials. In order to be manufactured, these dosage forms need specific flow properties so they can be placed into a container, remain stable over time, dispensed, handled and properly applied to the affected area by patients. Rheology is therefore crucially important as it will directly affect the way a drug is formulated and developed, the quality of the raw and finished product, the drug efficacy, the way a patient adheres to the prescribed drug, and the overall healthcare cost. It can be concluded that there are inherent and independent factors that affect the flow property of a medicated material during every stage of its manufacturing all the way to its use.

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Chitosan–magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential

Cited by 53 publications

References 21 publications

Rheological behavior and stability of ciprofloxacin suspension: Impact of structural vehicles and flocculating agent

Rheological behavior and stability of ciprofloxacin suspension: Impact of structural vehicles and flocculating agent

Influence of Flocculating Agents and Structural Vehicles on the Physical Stability and Rheological Behavior of Nitrofurantoin Suspension

Rheology in Pharmaceutical Formulations-A Perspective

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