Chitosan nanoparticles for lipophilic anticancer drug delivery: Development, characterization and in vitro studies on HT29 cancer cells

Gemcitabine Delivered by Fucoidan/Chitosan Nanoparticles Presents Increased Toxicity Over Human Breast Cancer Cells

“…The encapsulation of cisplatin into CH lipid NPs was reported, demonstrating increased apoptosis in cancer cells when compared with free cisplatin [41]. A recent paper reported that CH NPs loaded with curcumin reduced the drug uptake in normal cells, while the same was internalized into cancer cells [42]. Another study reported the internalization of CH-coated NPs loaded with doxorubicin into breast cancer cells cytoplasm and nucleus.…”

A green method for the production of an efficient bioimaging nanotool

“…[9][10][11] Dextran nanovesicles responsive to acidic pH and/ or esterase, and chitosan nanoparticles for cancer targeting are only some examples. [12][13][14] A recent trend is also the development of drug-loaded bioactive nanocarriers made from natural oils (such as grapeseed oil, sh oil and laurel leaf oil) and surfactant mixtures, as these are able to reduce harmful free radicals and eradicate cancer cells. 15 Among the plethora of nature-inspired products that can be exploited as a backbone for delivery systems, cardanol (CA) has received great attention.…”

Cholesterol-Modified Amino-Pullulan Nanoparticles as a Drug Carrier: Comparative Study of Cholesterol-Modified Carboxyethyl Pullulan and Pullulan Nanoparticles

“…The hydrophobic group plays a leading role in the process of self-assembly, whereas the hydrophilic amino and carboxyl groups play an important part in NP formation [16,25]. Due to the repulsive forces between NPs, amino-functionalized NPs with a positive-charge surface can prevent their aggregation [25] and increase the stability of NPs in vitro, with good targeting of tumor tissues and high cellular uptake [27,28]. Therefore, we can improve the drug curative effect by the rational design of high-drug loading with positive-charged NPs.…”