Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases

Panonnummal, Rajitha; Gopinath, D.; Biswas, Raja; Sabitha, M.; Jayakumar, R.

doi:10.1080/17425247.2016.1178232

Cited by 109 publications

(43 citation statements)

References 99 publications

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“…Regarding the previous section, CS is a unique cationic biocompatible and biodegradable (see Section 5) polysaccharide that can be modified, as required, according to the needed end-use application. This is particularly true for biomedical and pharmaceutical applications ranging from drug delivery systems [164] to functional biomaterials [165], also considering tissue engineering [166], cell culturing [167], regenerative scaffolds [168], wound healing [169], smart hydrogels [170], active nanoparticles [171], anticoagulants [172], gene therapy [173], etc. (Figure 9).…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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“…The key advantage of chitosan-based nanoparticles is their strong affinity for negatively charged cell surfaces and in vivo site-specific drug delivery. The release of therapeutic agents from chitosan-based nanoparticles is dependent upon polymer erosion, polymer-drug interactions, and their swelling potential, which are affected by the pH of the medium [87, 88]. In a recent study, Wu et al designed both recombinant human interleukin-2 (rhIL-2) and doxorubicin-loaded chitosan-based nanoparticles for the enhanced anticancer activity [89].…”

Section: Polymeric Nanomaterialsmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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“…Many beneficial pharmacological properties have been suggested for chitosan due to its biocompatibility, non-toxicity, biodegradability, antibacterial activity, antioxidant activity and muco-adhesive properties [5]. Furthermore, it has been introduced extensively in the pharmaceutical industry including the formation of tablets as a controlled release dosage form [6], a gel absorption enhancer [7], for drug dissolution in wound-healing products and in developing micro/nanoparticles. Chitosan is a weak polybase with a pKa around 6.5, implying that its charge density varies in the pH range of 6-6.5.…”

Section: Introductionmentioning

confidence: 99%

Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels

et al. 2019

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Hydrogel-based polymers are represented by those hydrophilic polymers having functional groups in their chain such as amine (NH2), hydroxyl [-OH], amide (-CONH-, -CONH2), and carboxyl [COOH]. These hydrophilic groups raise their potential to absorb fluids or aqueous solution more than their weights. This physicochemical mechanism leads to increased hydrogel expansion and occupation of larger volume, the process which shows in swelling behavior. With these unique properties, their use for biomedical application has been potentially raised owing also to their biodegradability and biocompatibility. Chitosan as a natural copolymer, presents a subject for hydrogel structures and function. This review aimed to study the structure as well as the function of chitosan and its hydrogel properties.

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Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases

Abstract: The authors believe that chitosan-based nanosystems, due to the special and specific advantages, will have a promising role in the management of infectious and inflammatory diseases.

Cited by 109 publications

References 99 publications

Modification of Chitosan for the Generation of Functional Derivatives

Modification of Chitosan for the Generation of Functional Derivatives

Evolution and clinical translation of drug delivery nanomaterials

Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels

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