Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

Mattaveewong, Tharinee; Wongkrasant, Preedajit; Chanchai, Sumalee; Pichyangkura, Rath; Chatsudthipong, Varanuj; Muanprasat, Chatchai

doi:10.1016/j.carbpol.2016.02.077

Cited by 99 publications

(62 citation statements)

References 30 publications

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“…It has been reported that the p65 subunit of NF-jB binding to the promoter of the MMP-9 gene could be suppressed by AMPK activation [65]. In addition, it has been found that chitosan oligosaccharides treatment increased AMPK activity, suppressed the NF-jB-mediated MMP-9 production [66]. Therefore, it is believed that NF-jB might be related to AMPK-induced MMP-9 decrease.…”

Section: Discussionmentioning

confidence: 99%

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Zhang

Tang

Zheng

et al. 2017

J Cellular Molecular Medi

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Blood‐spinal cord barrier (BSCB) disruption is a major process for the secondary injury of spinal cord injury (SCI) and is considered to be a therapeutic target for SCI. Previously, we demonstrated that metformin could improve functional recovery after SCI; however, the effect of metformin on BSCB is still unknown. In this study, we found that metformin could prevent the loss of tight junction (TJ) proteins at day 3 after SCI in vivo, but in vitro there was no significant difference of these proteins between control and metformin treatment in endothelial cells. This indicated that metformin‐induced BSCB protection might not be mediated by up‐regulating TJ proteins directly, but by inhibiting TJ proteins degradation. Thus, we investigated the role of metformin on MMP‐9 and neutrophils infiltration. Neutrophils infiltration is the major source of the enhanced MMP‐9 in SCI. Our results showed that metformin decreased MMP‐9 production and blocked neutrophils infiltration at day 1 after injury, which might be related to ICAM‐1 down‐regulation. Also, our in vitro study showed that metformin inhibited TNF‐α‐induced MMP‐9 up‐regulation in neutrophils, which might be mediated via an AMPK‐dependent pathway. Together, it illustrated that metformin prevented the breakdown of BSCB by inhibiting neutrophils infiltration and MMP‐9 production, but not by up‐regulating TJ proteins expression. Our study may help to better understand the working mechanism of metformin on SCI.

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Section: Discussionmentioning

confidence: 99%

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Zhang

Tang

Zheng

et al. 2017

J Cellular Molecular Medi

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“…Chitosan oligosaccharide (COS), derived through hydrolysis of chitosan [6], is a water-soluble compound and has been proved as an effective elicitor of plant immunity. Generally, elicitor pretreatment is an advanced method for plant resistance because it costs less energy than directly induced defense and is less harmful to plant growth [7].…”

Section: Introductionmentioning

confidence: 99%

Pre-Harvest Treatment of Chitosan Oligosaccharides Improved Strawberry Fruit Quality

Bose

Wang

et al. 2018

IJMS

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Chitosan oligosaccharide (COS), derived through hydrolysis of chitosan, has been proved to be an effective plant immunity elicitor, eco-friendly, and easily soluble in water, and influenced several secondary metabolites content to improve fruit qualities. COS are widely used in agriculture to improve the defense response in plants. The purpose of this study was to investigate the pre-harvest treatment effect of COS on the quality of strawberry (Fragaria × ananassa cv. qingxiang). COS was dissolved in distilled water at a concentration of 50 mg·L−1 and sprayed at four different growth stages of strawberry plants, namely seedling stage, before flowering, fruit coloring (the stage of fruit from white to red) and full bloom. Uniform size, shape, color, without any visible damage, and disease-free fruits were harvested for determining the quality. The results showed that the fruit firmness, viscosity, lignin, sugars, protein, total soluble solid, and titratable acidity content increased in COS-treated fruits compared to control. In addition, COS pre-harvest treatment had a positive effect on anthocyanin, total phenol, flavonoid, vitamin C content and DPPH(2,2-diphenyl-1-picrylhydrazyl) scavenging activity of strawberry. Moreover, COS also increased the cell wall composition and regulated gene expression of some important enzymes involved in ethylene compound biosynthesis and cell wall degradation. The finding of this study suggests that pre-harvest application of COS is very useful for improving quality and antioxidant capacity of strawberry.

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“…Chitooligosaccharides (COS), the degraded products of chitosan or chitin, are oligomers of β-(1-4)-linked-d-glucosamine with remarkable biological activities at molecular and cellular levels. It has been reported that COS possess a wide range of biological activities, including anti-inflammatory (Huang et al, 2016;Molteni, Gemma, & Rossetti, 2016;Muanprasat et al, 2015;Paul-Clark et al, 2012), anti-obesity and lipid-lowering (Egan, Sweeney, Hayes, & O'Doherty, 2015;Pokhis, Bitterlich, Cornelli, & Cassano, 2015;Trivedi et al, 2016;Zou et al, 2016a), antidiabetic (Kondo, Nakatani, Hayashi, & Ito, 2000;Liu, Cai, & Chiang, 2015), antihypertensive (Huang, Mendis, & Kim, 2005;Ngo, Qian, Je, Kim, & Kim, 2008), immunostimulatory (Bahar, O'Doherty, Maher, McMorrow, & Sweeney, 2012;Seo et al, 2000;Xing et al, 2017;Zhang, Liu, Peng, Han, & Yang, 2014), and anticancer effects (Fernandes et al, 2012;Masuda et al, 2014;Mattaveewong et al, 2016;Muanprasat et al, 2015;Zou et al, 2016;Zou, Yuan, Yang, Zhai, & Wang, 2018). Among them, the enhancement of immune functions might be substantially effective to those suffering from declining immunity, such as the elderly people (Muanprasat & Chatsudthipong, 2017).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Chitosan Oligosaccharides Against Cyclophosphamide‐Induced Immunosuppression and Irradiation Injury in Mice

Zhai

Yang

Pan

et al. 2018

Journal of Food Science

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Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

Cited by 99 publications

References 30 publications

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Pre-Harvest Treatment of Chitosan Oligosaccharides Improved Strawberry Fruit Quality

Protective Effect of Chitosan Oligosaccharides Against Cyclophosphamide‐Induced Immunosuppression and Irradiation Injury in Mice

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