Chitosan-poly(aminopropyl/phenylsilsesquioxane) hybrid nanocomposite membranes for antibacterial and drug delivery applications

Kummari, Subba Venkata Krishna Rao; Kummara, Madhusudana Rao; Palem, Ramasubba Reddy; Nagellea, Sivagangi Reddy; Shchipunov, Yu. A.; Ha, Chang‐Sik

doi:10.1002/pi.4789

Cited by 23 publications

(5 citation statements)

References 41 publications

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“…While considering particular purposes, this modification of the physical and chemical properties of nano-clay embedded polymeric hydrogels is critical. As a result, the inflating characteristics, heat withstandability, and mechanical durability of the augmented hydrogel may be tuned using nano-clay embedded polymer hydrogel systems [25,26].…”

Section: Introductionmentioning

confidence: 99%

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Rahmani

Pourmadadi

Ghorbanian

et al. 2022

Engineering in Life Sciences

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Despite its widespread usage as a chemotherapy drug in cancer treatment, doxorubicin (DOX) has limitations such as short in vivo circulation time, low solubility, and poor permeability. In this regard, a pH-responsive chitosan (CS)-montmorillonite (MMT)-nitrogen-doped carbon quantum dots (NCQDs) nanocomposite was first developed, loaded with DOX, and then incorporated into a double emulsion to further develop the sustained release. The incorporated NCQDs into the CS-MMT hydrogel exhibited enhanced loading and entrapment efficiencies. The presence of NCQDs nanoparticles in the CS-MMT hydrogel also resulted in an extended pH-responsive release of DOX over a period of 96 h compared to that of CS-MMT-DOX nanocarriers at pH 5.4. Based on the Korsmeyer-Peppas model, there was a controlled DOX release at pH 5.4, while no diffusion was observed at pH 7.4, indicating fewer side effects. MTT assay showed that the cytotoxicity of DOX-loaded CS-MMT-NCQDs hydrogel nanocomposite was significantly higher than those of free DOX (p < 0.001) and CS-MMT-NCQDs (p < 0.001) on MCF-7 cells. Flow cytometry results demonstrated that a higher

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Section: Introductionmentioning

confidence: 99%

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Rahmani

Pourmadadi

Ghorbanian

et al. 2022

Engineering in Life Sciences

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“…Utilizing the plethora of functional groups on GO, recently it has been covalently functionalized to enhance compatibility and impart bioactivity. This covalent functionalization has been done with traditional types of polymers, natural polymers, conductive polymers, and systems containing polypeptides . While creating interesting materials, they are typically fibers or films, not robust fully three‐dimensional (3‐D) materials.…”

Section: Introductionmentioning

confidence: 99%

Peptide‐functionalized reduced graphene oxide as a bioactive mechanically robust tissue regeneration scaffold

Holt

Arnold

Sydlik

2017

Polymer International

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Bioactive, synthetic materials represent next-generation composites for tissue regeneration. Design of contemporary materials attempts to recapitulate the complexities of native tissue; however, few successfully mimic the order in nature. Recently, graphene oxide (GO) has emerged as a scaffold due to its potential for bioactive functionalization and long-range order instilled by the self-assembly of graphene sheets. Chemical reduction of GO results in a more compatible material with enhanced properties but compromises the ability to functionalize the graphenic backbone. However, using Johnson-Claisen rearrangement chemistry, functionalization is achieved that is not liable to reduction. From reduced Claisen graphene, we polymerized short homopeptides from -amino acid N-carboxyanhydride monomers of glutamate and lysine to result in functionalized graphenes (pGlu-rCG and pLys-rCG) that are cytocompatible, degradable, and bioactive. Exposure to NIH-3T3 fibroblasts and RAW 264.7 macrophages revealed that the materials are cytocompatible and do not alter important sub-cellular compartments. Powders were hot pressed to form mechanically stiff (E ′ : 41 and 49 MPa), strong (UCS: 480 and 140 MPa), and tough (U T : 2898 and 584 J m −3 × 10 4 ) three-dimensional constructs (pGlu-rCG and pLys-rCG, respectively). Overall, we report a robust chemistry and processing strategy for facile bioactive functionalization of compatible, reduced Claisen graphene for three-dimensional biomedical applications.

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“…The first step has 1.28% of weight loss between 30-80 • C attributed to the loss of moisture from the nanogels. While the second stage was observed in the temperature range of 204-375 • C accounting for 72.44% of weight loss, which is due to the decomposition of the grafted polymer side chains and Cs [37]. The final stage of decomposition observed in the temperature range of 375-519 • C accounted for up to 15.24% of weight loss in nanogels, which is due to the decomposition of the main chain of the polymer network.…”

Section: Ftirmentioning

confidence: 96%

“…Chitosan (Cs), one of the most abundant naturally occurring cellulose polymers, which is generally obtained by the deacetylation of chitin extracted from the shells of crustaceans [36,37], has been used as an effective material in various applications including DDS. It is an amino polysaccharide made up of the copolymers of D-glucosamine and N-acetylated D-glucosamine which are linked via β-1,4-glycosidic linkages [37], and used because of the many attractive properties such as excellent biocompatibility, biodegradability, muco-adhesivity, non-toxicity, and non-immunogenicity. Furthermore, Cs could be depolymerized by treating with NaNO 2 to obtain highly soluble lower molecular weight polymer chains without any structural changes [38].…”

Section: Introductionmentioning

confidence: 99%

Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine

Nagella,

Choi,

Park

et al. 2023

IJMS

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This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH) nanogels were prepared by varying the composition of comonomers such as MMA, HEMA, and redox initiator CAN. The nanogels were then characterized using FTIR, TGA, SEM, and TEM. The CsPMH nanogels showed greater encapsulation efficiencies from 43.20–91.77%. Computational studies were also conducted to evaluate the interaction between the drug and CsPMH nanoparticles. Finally, BPV-loaded nanoparticles were used to examine their in vitro release behavior. At pH 7.4, all the drug carriers displayed the “n” value around 0.7, thus the BPV release follows anomalous diffusion. Drug carrier 7 demonstrated a steady and sustained release of BPV for approximately 24 h and released about 91% of BPV, following the K-P mechanism of drug release. On the other hand, drug carrier 6 exhibited controlled release for approximately 12 h and released only 62% of BPV.

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Chitosan-poly(aminopropyl/phenylsilsesquioxane) hybrid nanocomposite membranes for antibacterial and drug delivery applications

Abstract: The incorporation of poly(aminopropyl/phenylsilsesquioxane) (PAPSQ) into chitosan gave membranes exhibiting high thermal stability and tunable swelling property, and that were good templates for loading of 5‐fluorouracil (5‐FU) and production of Ag nanoparticles around PAPSQ.

Cited by 23 publications

References 41 publications

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Peptide‐functionalized reduced graphene oxide as a bioactive mechanically robust tissue regeneration scaffold

Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine

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