Chitosan/poly(lactic acid) blends as drug delivery systems

Marudova, Maria; Yorov, Tsvetan

doi:10.1080/00914037.2018.1525728

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Chitosan (CS) is a cationic polysaccharide widely and abundantly distributed in nature, 2 offering the advantages of excellent film‐forming properties 3 and biological properties (such as biodegradability, biocompatibility, 4 good gases permeability, 5 antibacterial activity, 6 and nontoxicity 7 ). Consequently, the last decade has witnessed significant development of CS applications in fruit/vegetable preservation 8 and food packaging 9 …”

Section: Introductionmentioning

confidence: 99%

Hydrophobic chitosan/salicylic acid blends film with excellent tensile properties for degradable food packaging plastic materials

Liu

Wang

et al. 2022

J of Applied Polymer Sci

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Degradable plastic materials made from biopolymer Chitosan (CS) present one of the alternatives to plastic bags for food packaging, but the stability and durability limits its application. Herein, we demonstrated a facile method of producing hydrophobic CS/salicylic acid (SA) film in organic phase for the first time. SA, which can destruct hydrogen bonds of CS was initially blended with CS in N, N-dimethylacetamide using a catalyst. On this basis, CS/SA blend was crosslinked via isocyanate to the hydrophobic CS-SA film. The derivatives structures were characterized using SEM, FTIR, UV-Vis, and fluorescence spectrum. The film-forming ability of CS was maintained, while the hydrophobicity, mechanical strength, and thermal stability of films were improved.These dramatic improvements occurred with the blending effects of CS and SA and the crosslinking effects of organic isocyanate cross linker. The permeabilities to water vapor and water-soluble substances of film were promoted, which are conducive to the application of the film as food packaging. The demonstration of bacteriostatic and grape preservation properties featured the super performance of the synthetic CS/SA film. Our work provides novel food preservation materials, which can replace the commonly used packaging materials and promote the development of the degradable food packaging plastic bags field.

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Section: Introductionmentioning

confidence: 99%

Hydrophobic chitosan/salicylic acid blends film with excellent tensile properties for degradable food packaging plastic materials

Liu

Wang

et al. 2022

J of Applied Polymer Sci

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Section: Chitosan Films In Drug Delivery Applicationsmentioning

confidence: 99%

“…[116] Controlled release of salicylic acid from chitosan polylactic acid blended film was investigated and found that the release was influenced by the ratio of chitosan and PLA, hydrophobic nature of chitosan and the complex formed between the drug and chitosan. [117] Ascorbic acid crosslinked chitosan films were employed by Kristó et al [118] for the buccal administration of cationic and anionic drugs. The cationic drug cetirizine hydrochloride and anionic diclofenac were used for the study.…”

Section: Chitosan Films In Drug Delivery Applicationsmentioning

confidence: 99%

Chitosan‐Based Films in Drug Delivery Applications

2022

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The idea of controlled release of the pharmaceutical active ingredients in the human body has become a major thrust for designing sophisticated drug delivery systems. The mandatory requirement for developing these delivery vehicles is to support the delivery of pharmaceutical drugs in a pharmokinetically controlled manner. Though a variety of synthetic polymers address the above mentioned conditions, their toxicity and high cost have ultimately hampered their role. Consequently, natural polymers owing to their biocompatibility, biodegradability, and nontoxicity can be used for the successful designing of drug delivery supports. One such natural polymer extracted from crustaceans, is chitosan. Chitosan can be used in drug delivery in various forms like hydrogels, nanoparticles, nanofibers, films, etc. This review presents the properties of chitosan films and their pivotal role in various drug delivery approaches.

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“…176 During recent years, various PLA blends have been introduced for CDDSs as beneficial copolymers for a wide range of medical and pharmaceutical applications. 173,177,178 In the last years, many PEGylated PLA hydrogels have been synthesized and investigated for their application in CDDSs. 151 Sirc et al have demonstrated the controlled release of some drugs based on PLA/PEG hydrogels.…”

Section: Applications Of Pla Blends In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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Chitosan/poly(lactic acid) blends as drug delivery systems

Cited by 10 publications

References 22 publications

Hydrophobic chitosan/salicylic acid blends film with excellent tensile properties for degradable food packaging plastic materials

Hydrophobic chitosan/salicylic acid blends film with excellent tensile properties for degradable food packaging plastic materials

Chitosan‐Based Films in Drug Delivery Applications

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

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