Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding

Dentin biomodification: strategies, renewable resources and clinical applications

“…Enhancement of the biomechanical properties of the dentin matrix is directly related to immediate increased dentin-resin bond strength to sound [47, 86, 113, 114] and caries-affected dentin [85]. A closer look at the interface components shows that the mechanical properties of the underlying dentin and hybrid layer are significantly improved and largely attributed to agent-mediated non-enzymatic collagen cross-linking [79, 80].…”

Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cement

“…Low molecular weight and viscosity chitosan (CH), purchased from Fluka, was purified by dissolving in 0.1 mol/L acetic acid, precipitated in 0.1 mol/L NaOH and the precipitate was washed with ethanol/water (70/30 v/v) mixture followed by freeze drying. 28 The solution of chitosan was prepared by dissolving in 0.1 mol/L acetic acid to be used to modify the commercial polyacrylic acid (PAA) liquid of the glass ionomer as described previously. 27 The GIC liquids were modified with chitosan (CH) at different volume percents (v/v %): 0% CH (control; unmodified group), 5% CH, 10% CH, 25% CH, and 50% CH.…”

Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding

“…9 Cross-linkers such as glutaraldehyde (GA), carbodiimide, tannic acid, proanthocyanidine, genipin or chitosan/riboflavin have been proved effective to introduce additional cross-links, thus improving the mechanical properties of dentine collagen, reducing the susceptibility of collagen to enzymatic degradation and increasing the stability of resin-dentine interface. [9][10][11][12][13][14][15][16] Despite the potential benefits of cross-linkers, there have been some concerns regarding their use such as undesirable additional steps 17 , extended application time that may not be clinically applicable 15 , cytotoxicity 18,19 , discoloration 12 and 4 hampering effect on the polymerization of resin monomers. 16 Hence, the effectiveness and actions of these cross-linkers are still under investigations.…”