Chitosan/silk fibroin composite scaffolds for wound dressing

Abstract

Three‐dimensional (3D) chitosan/silk fibroin (CS/SF) porous composite scaffolds have been prepared by simply coating a thin layer of CS onto spunlaced SF scaffolds via hydrogen‐bonding assembly technique, and they were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X‐ray diffraction (XRD), and mechanical property measurements. The results show that porous scaffolds have a pore diameter around 50–200 μm, and improved mechanical property compared with SF, resulting from strong intermolecular hydrogen bonding interactions between CS and SF, together with the maintained β‐sheet structure of SF. The medical and biological properties of the composite scaffolds were further evaluated. The results demonstrate that they possess good biocompatibility and a broad spectrum of antimicrobial properties. The in vivo animal experiments show that the composite scaffolds promote skin regeneration of rats without any teratogenic effect and inflection, thus they are very promising in the application of wound dressings. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42503.

Efficient Wound Healing Using a Synthetic Nanofibrous Bilayer Skin Substitute in Murine Model

“…61 In addition, the intermolecular cross-linkage among components of hybrid scaffolds was found responsible for improvement of the mechanical and biological performance of these scaffolds compared with single component scaffold. 62,63 Conclusively, this study supports proceeding to a randomized clinical trial to examine the effectiveness of this bilayer scaffold in patients with full-thickness wounds.…”

Silk fibroin/amniotic membrane 3D bi-layered artificial skin

“…Table 1 here applications. [12][13][14][15][16][17][18]. A number of silk containing products are used in plastic surgery applications, which are approved by FDA [19].…”

Biomaterials for Skin Substitutes

“…Chitosan alone and in combination with other materials has been widely used for wound dressings and skin substitutes . It has been used in the form of both freeze‐dried sponges and hydrogels, mainly in combination with other biomaterials like collagen, gelatin, and fibrin .…”