Chitosan/silk fibroin/nitrogen-doped carbon quantum dot/α-tricalcium phosphate nanocomposite electrospinned as a scaffold for wound healing application: In vitro and in vivo studies

Dehghani, Niloofar; Haghiralsadat, Fateme; Yazdian, Fatemeh; Sadeghian‐Nodoushan, Fatemeh; Ghasemi, Nasrin; Mazaheri, Fahime; Pourmadadi, Mehrab; Naghib, Seyed Morteza

doi:10.1016/j.ijbiomac.2023.124078

Cited by 29 publications

(10 citation statements)

References 68 publications

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“…One important factor in the design of CS-based biomaterials is represented by the mechanisms of its degradation in the biological environment [ 106 ]. Numerous synthesis methods have been studied to create CS, which degrades over days, weeks, or even months, depending on the needs of the specific application or biodevice [ 105 , 106 , 107 , 108 ]. Furthermore, studies [ 109 , 110 , 111 , 112 ] reported that by adding bioactive components to functionalized nanomaterials, accelerated healing was achieved by regulating the metabolic pathway and growth factors.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Stoica

Albuleț

Bîrcă

et al. 2023

IJMS

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Injuries and diseases of the skin require accurate treatment using nontoxic and noninvasive biomaterials, which aim to mimic the natural structures of the body. There is a strong need to develop biodevices capable of accommodating nutrients and bioactive molecules and generating the process of vascularization. Electrospinning is a robust technique, as it can form fibrous structures for tissue engineering and wound dressings. The best way of forming such meshes for wound healing is to choose two polymers that complement each other regarding their properties. On the one hand, PVA is a water-soluble synthetic polymer widely used for the preparation of hydrogels in the field of biomedicine owing to its biocompatibility, water solubility, nontoxicity, and considerable mechanical properties. PVA is easy to subject to electrospinning and can offer strong mechanical stability of the mesh, but it is necessary to improve its biological properties. On the other hand, CS has good biological properties, including biodegradability, nontoxicity, biocompatibility, and antimicrobial properties. Still, it is harder to electrospin and does not possess as good mechanical properties as PVA. As these structures also allow the incorporation of bioactive agents due to their high surface-area-to-volume ratio, the interesting point was to incorporate usnic acid into the structure as it is a natural and suitable alternative agent for burn wounds treatment which avoids an improper or overuse of antibiotics and other invasive biomolecules. Thus, we report the fabrication of an electrospun nanofibrous mesh based on PVA, chitosan, and usnic acid with applications in wound healing. The obtained nanofibers mesh was physicochemically characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). In vitro biological assays were performed to evaluate the antimicrobial properties of the samples using the MIC (minimum inhibitory concentration) assay and evaluating the influence of fabricated meshes on the Staphylococcus aureus biofilm development, as well as their biocompatibility (demonstrated by fluorescence microscopy results, an XTT assay, and a glutathione (GSH) assay).

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Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Stoica

Albuleț

Bîrcă

et al. 2023

IJMS

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“… 184,185 When applied to wound treatment, nanofibers can release drugs, promoting wound healing and preventing infection. 186,187 …”

Section: Functionality Of Electrostatically Spun Nanofiber Materialsmentioning

confidence: 99%

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Zheng,

Xi,

Weng

2024

RSC Adv.

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“…In recent years, more and more research has been devoted to developing SF scaffolds with antibacterial properties for wound dressings (Babu et al, 2018;Tariq et al, 2021;Chizari et al, 2022;Dong et al, 2022;Dehghani et al, 2023;Li et al, 2024). Interestingly, Sen et al immobilized SF into the surface of polyurethane (PU) scaffolds.…”

Section: Skin Tissue Regenerationmentioning

confidence: 99%

Silk fibroin-based scaffolds for tissue engineering

Ma,

Dong,

Lai

et al. 2024

Front. Bioeng. Biotechnol.

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Silk fibroin is an important natural fibrous protein with excellent prospects for tissue engineering applications. With profound studies in recent years, its potential in tissue repair has been developed. A growing body of literature has investigated various fabricating methods of silk fibroin and their application in tissue repair. The purpose of this paper is to trace the latest developments of SF-based scaffolds for tissue engineering. In this review, we first presented the primary and secondary structures of silk fibroin. The processing methods of SF scaffolds were then summarized. Lastly, we examined the contribution of new studies applying SF as scaffolds in tissue regeneration applications. Overall, this review showed the latest progress in the fabrication and utilization of silk fibroin-based scaffolds.

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Chitosan/silk fibroin/nitrogen-doped carbon quantum dot/α-tricalcium phosphate nanocomposite electrospinned as a scaffold for wound healing application: In vitro and in vivo studies

Cited by 29 publications

References 68 publications

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Silk fibroin-based scaffolds for tissue engineering

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