2017
DOI: 10.1111/jre.12510
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Chitosan‐triclosan particles modulate inflammatory signaling in gingival fibroblasts

Abstract: Our results show that chitosan-triclosan particles are able to modulate the inflammatory response in gingival fibroblasts. This effect might be useful in the prevention and/or treatment of inflammation in periodontal diseases.

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Cited by 16 publications
(11 citation statements)
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“…In a related report, TCS also reduced the capacity of natural killer (NK) lymphocytes to lyse chronic myelogenous leukemia K562 cells [154]. Recently, chitosan-TCS particles reduced the expression of IL-1 β -induced Cox2 and Il6 , among other immune molecules in gingival fibroblasts (Table 4) [155], showcasing the vast amenability of this antimicrobial to nanoparticle manipulation.…”
Section: Immunity and Inflammationmentioning
confidence: 99%
“…In a related report, TCS also reduced the capacity of natural killer (NK) lymphocytes to lyse chronic myelogenous leukemia K562 cells [154]. Recently, chitosan-TCS particles reduced the expression of IL-1 β -induced Cox2 and Il6 , among other immune molecules in gingival fibroblasts (Table 4) [155], showcasing the vast amenability of this antimicrobial to nanoparticle manipulation.…”
Section: Immunity and Inflammationmentioning
confidence: 99%
“…Pavez et al 13 sintetizaram partículas de quitosana-triclosana e avaliaram sua morfologia, carga, biocompatibilidade e análise de expressão gênica em fibroblastos gengivais humanos. Seus resultados apontaram que a quitosana-triclosan induziu uma resposta transcricional anti-inflamatória nos fibroblastos gengivais de IL-1 β13.…”
Section: Discussionunclassified
“…However, PMPC-CS did not have any intrinsic antibiofilm capability. Thus, the hydrophobic antimicrobial drug triclosan 66,67 was encapsulated into these nanocapsules with a drug loading content (DLC) and drug loading efficiency (DLE) of 46% and 61%, respectively. All the loaded nanocapsules substantially prohibited S. aureus biofilm formation after 3 h of treatment and their activity was considerably higher at low pH 5.0 compared with physiological pH 7.4.…”
Section: Biomaterials Science Reviewmentioning
confidence: 99%