Chitosan tubes can restore the function of resected phrenic nerves

Tanaka, Nobuyoshi; Matsumoto, Isao; Suzuki, M; Kaneko, Mitsuaki; Nitta, Koh‐hei; Seguchi, Ryuta; Ooi, Akishi; Takemura, Hirofumi

doi:10.1093/icvts/ivv091

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…A chitosan hollow tube employed for regeneration of the injured rodent transected sciatic nerve yielded results comparable to autologous nerve graft repair [ 83 ]. Implantation of chitosan nanofiber tube could partially restore the function of a damaged phrenic nerve in beagle dogs as seen in improvement of diaphragm movement, slow phrenic nerve conduction, connection of the damaged nerve by newly regenerating nerve fibers surrounded by granulation tissue within the chitosan nanofiber tube [ 84 ]. The loss of spinal cord tissue and cavity formation impedes the repair of damage to the spinal cord.…”

Section: Applicationsmentioning

confidence: 99%

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

et al. 2015

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Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application. Nevertheless, chemical modification into composites or hydrogels brings to it new functional properties for different applications. Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. This review presents the recent research, trends and prospects in chitosan. Some special pharmaceutical and biomedical applications are also highlighted.

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Section: Applicationsmentioning

confidence: 99%

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

et al. 2015

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“…It was confirmed that the C-tube can be safely and effectively applied in the recovery and regeneration of the damaged phrenic and sympathetic nerves [144]. Tanaka et al conducted similar experiments following Matsumoto's process and reached the same conclusion [145]. Yu et al prepared MC with a chitosan amine group as material, and then formed scaffolds by radical polymerization and cross-linking.…”

Section: Nervous Systemmentioning

confidence: 85%

Research Progress on Emerging Polysaccharide Materials Applied in Tissue Engineering

Chen

Tian

et al. 2022

Polymers

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The development and application of polysaccharide materials are popular areas of research. Emerging polysaccharide materials have been widely used in tissue engineering fields such as in skin trauma, bone defects, cartilage repair and arthritis due to their stability, good biocompatibility and reproducibility. This paper reviewed the recent progress of the application of polysaccharide materials in tissue engineering. Firstly, we introduced polysaccharide materials and their derivatives and summarized the physicochemical properties of polysaccharide materials and their application in tissue engineering after modification. Secondly, we introduced the processing methods of polysaccharide materials, including the processing of polysaccharides into amorphous hydrogels, microspheres and membranes. Then, we summarized the application of polysaccharide materials in tissue engineering. Finally, some views on the research and application of polysaccharide materials are presented. The purpose of this review was to summarize the current research progress on polysaccharide materials with special attention paid to the application of polysaccharide materials in tissue engineering.

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“…Chitosan-based nerve conduits, alone or in combination with other biomaterials, have been found to bridge efficiently peripheral nerve defects (Gnavi et al 2013). Apart from rats (Gonzalez-Perez et al 2015;Fregnan et al 2016), chitosan conduits have been tested in several animal models for nerve regeneration, such as dogs (Tanaka et al 2015) and goats (Muheremu et al 2017). To provide an example, chitosan nerve conduits having an internal longitudinal chitosan membrane were used on a 10-mm sciatic nerve defects in adult healthy and diabetic rats and provide an enhancement in functional and morphological nerve regeneration (Meyer et al 2016).…”

Section: Chitosan As a Promising Materials For Regenerative Medicinementioning

confidence: 99%

Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films

et al. 2019

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Regenerative medicine is continuously facing new challenges and it is searching for new biocompatible, green/natural polymer materials, possibly biodegradable and non-immunogenic. Moreover, the critical importance of the nano/microstructuring of surfaces is overall accepted for their full biocompatibility and in vitro/in vivo performances. Chitosan is emerging as a promising biopolymer for tissue engineering and its application can be further improved by exploiting its nano/microstructuration. Here, we report the state of the art of chitosan films and scaffolds nano/micro-structuration. We show that it is possible to obtain, by solvent casting, chitosan thin films with good mechanical properties and to structure them at the microscale and even nanoscale level, with resolutions down to 100 nm.

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Chitosan tubes can restore the function of resected phrenic nerves

Abstract: Our results suggest that, in addition to morphological improvement, C-tube implantation can functionally improve the injured phrenic nerve by promoting phrenic nerve regeneration.

Cited by 12 publications

References 13 publications

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

Research Progress on Emerging Polysaccharide Materials Applied in Tissue Engineering

Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films

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