Chitosan/xanthan gum porous scaffolds incorporated with in-situ-formed poly(lactic acid) particles: Their fabrication and ability to adsorb anionic compounds

Inphonlek, Supharat; Niamsiri, Nuttawee; Sunintaboon, Panya; Sirisinha, Chakrit

doi:10.1016/j.colsurfa.2020.125263

Cited by 18 publications

(10 citation statements)

References 46 publications

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“…Then the polymer material and the porogen mixed emulsion are added to the mold for evaporative solidification. Finally, residual porogen particles are removed 43–53 . The technology relies on molds and porogens, and different shapes of scaffolds can be constructed using different molds.…”

Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

“…In addition, multifunctional modification of the surface is often required to compensate for the lack of bioactivity and biocompatibility of the scaffold. Birru et al selected human mesenchymal stem cells or natural polymer materials to combine on the scaffold surface to accelerate bone regeneration after scaffold implantation in vivo 51–53 …”

Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

“…Birru et al selected human mesenchymal stem cells or natural polymer materials to combine on the scaffold surface to accelerate bone regeneration after scaffold implantation in vivo. [51][52][53]…”

Section: Solvent Casting-particulate Leaching Techniquementioning

confidence: 99%

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Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

Lin

et al. 2022

MedComm – Biomaterials and Applications

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Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the structure and composition of cancellous bone, building a bionic 3D scaffold via customized‐3D printing technology is the key to solving the problem. As the earliest degradable medical polymer material approved by Food and Drug Administration, polylactic acid has been proved to have excellent biosafety and can be copolymerized or blended with other synthetic polymers, natural polymers, and inorganic materials to improve its performance to better meet clinical applications. A series of biodegradable bone repair scaffolds based on polylactic acid composites and 3D printing technology are developed to achieve large bone defects. Here, we review the composition and structure of cancellous bone, highlighting the relationship to the requirements of bone repair scaffolds. The different types of polylactic‐acid‐based materials applied in 3D printing technology are described, emphasizing the connection between materials, preparation methods, and applications.

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Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

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Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

Lin

et al. 2022

MedComm – Biomaterials and Applications

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“…The secondary structure of XG can be formed at low salt concentrations or high temperatures and can be depicted as a five-fold right-hand helical arrangement with a diameter of 1.9 nm and a pitch of 4.7 nm, capable of thermally induced configurational conversion [ 184 ]. XG is stable in a wide span of ionic strength, pH, and temperature and is also soluble both in hot and cold water, requiring vigorous shaking when exposed to aqueous environment to prevent the chump appearance [ 185 ]. The solutions of XG comport as non-Newtonian fluids and have a greatly pseudoplastic behavior, where the apparent viscosity altered considerably with the shear rate and/or with time [ 186 ].…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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“…A three-dimensional porous structure can improve the permeability of the wound dressing, and at the same time provide sufficient space for cell growth. It has previously been reported that porous structures promote skin regeneration and wound healing [ 5 , 10 ]. Furthermore, porous structures offer a larger surface area that could allow active agents to diffuse outwards from the matrix in an extremely efficient manner [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

et al. 2021

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: This study explores the feasibility of modifying the surface liquid spraying method to prepare porous bioscaffolds intended for wound dressing applications. For this purpose, gentamicin sulfate was loaded into polylactide-polyvinyl alcohol bioscaffolds as a highly soluble (hygroscopic) model drug for in vitro release study. Moreover, the influence of inorganic salts including NaCl (10 g/L) and KMnO4 (0.4 mg/L), and post-thermal treatment (T) (80 °C for 2 min) on the properties of the bioscaffolds were studied. The bioscaffolds were characterized by scanning electron microscopy, Fourier Transform infrared spectroscopy, and differential scanning calorimetry. In addition, other properties including porosity, swelling degree, water vapor transmission rate, entrapment efficiency, and the release of gentamicin sulfate were investigated. Results showed that high concentrations of NaCl (10 g/L) in the aqueous phase led to an increase of around 68% in the initial burst release due to the increase in porosity. In fact, porosity increased from 68.1 ± 1.2 to 94.1 ± 1.5. Moreover, the thermal treatment of the Polylactide-polyvinyl alcohol/NaCl (PLA-PVA/NaCl) bioscaffolds above glass transition temperature (Tg) reduced the initial burst release by approximately 11% and prolonged the release of the drug. These results suggest that thermal treatment of polymer above Tg can be an efficient approach for a sustained release.

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Chitosan/xanthan gum porous scaffolds incorporated with in-situ-formed poly(lactic acid) particles: Their fabrication and ability to adsorb anionic compounds

Cited by 18 publications

References 46 publications

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

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