Chitosan/β-glycerophosphate in situ gelling mucoadhesive systems for intravesical delivery of mitomycin-C

Kolawole, Oluwadamilola M.; Lau, Wing Man; Khutoryanskiy, Vitaliy V.

doi:10.1016/j.ijpx.2019.100007

Cited by 36 publications

(41 citation statements)

References 51 publications

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“…The retention of CHI and CHI/POZ films containing 0.1% NaFl on freshly isolated bovine cornea was assessed using a flow-through in vitro technique with fluorescent detection. This methodology has been previously used to study the retention of various materials on different mucosal surfaces, including ocular tissues, and it was validated against the other techniques established in assessment of mucoadhesive properties [35,36,38,61,62].…”

Section: Mucosal Retention Of Blend Films On Ex Vivo Corneal Tissuementioning

confidence: 99%

Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies

Abilova

Kaldybekov

Ozhmukhametova

et al. 2019

European Polymer Journal

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Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, wide angle x-ray diffraction, tensile testing and scanning electron microscopy. All these studies indicate that there is a weak intermacromolecular hydrogen bonding between these polymers, which facilitates their complete miscibility in solid state. These films were formulated with sodium fluorescein as a model drug and were evaluated for their potential application in ocular drug delivery both in vitro and in vivo. It was established that the films are biocompatible and mucoadhesive; they are capable of providing a sustained drug release when administered topically on the cornea.

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Section: Mucosal Retention Of Blend Films On Ex Vivo Corneal Tissuementioning

confidence: 99%

Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies

Abilova

Kaldybekov

Ozhmukhametova

et al. 2019

European Polymer Journal

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“…By plotting the variation of G and G as a function of the frequency applied, the intersection of the two plots depicts the gelation point [71]. A gelation temperature in the range of 30-36 • C is preferable, especially for in situ gelling systems [68,72].…”

Section: Natural Polymer-based Hydrogels In Anti-cancer Therapymentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

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The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

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“…Chitosan is a polysaccharide with a chemical structure similar to vegetable fibre cellulose that exhibits antifungal and antimicrobial activity, the inhibition of tumour cell growth and imparts controlled release activity to delivery technologies [ 257 ]. Chitosan has been used to sustain the release of APIs [ 258 , 259 ], is a mucoadhesive [ 260 , 261 , 262 ] and a positive charge inducer [ 238 , 263 ]. The biocompatibility of chitosan and ability to induce the production of endotoxins has been reported when using scaffold implants in a mammalian model [ 264 ].…”

Section: Biocompatibility Of Biomaterials Used For Nanoencapsulatimentioning

confidence: 99%

Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches

et al. 2020

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Nanoencapsulation is an approach to circumvent shortcomings such as reduced bioavailability, undesirable side effects, frequent dosing and unpleasant organoleptic properties of conventional drug delivery systems. The process of nanoencapsulation involves the use of biomaterials such as surfactants and/or polymers, often in combination with charge inducers and/or ligands for targeting. The biomaterials selected for nanoencapsulation processes must be as biocompatible as possible. The type(s) of biomaterials used for different nanoencapsulation approaches are highlighted and their use and applicability with regard to haemo- and, histocompatibility, cytotoxicity, genotoxicity and carcinogenesis are discussed.

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Chitosan/β-glycerophosphate in situ gelling mucoadhesive systems for intravesical delivery of mitomycin-C

Abstract: Graphical abstract

Cited by 36 publications

References 51 publications

Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies

Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches

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