Chlamydia pneumoniae: An Important Pathogen in Chronic Bronchitis

Lorenz, Joachim

doi:10.1007/978-88-470-2280-5_14

Cited by 1 publication

(2 citation statements)

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“…Cp was detected in atherosclerotic plaques by transmission electron microscopy (TEM), immunofluorescence, polymerase chain reaction (PCR) and culture [1, 6,7,9,11]. Cp is a well-known pathogen in acute and chronic respiratory infections [10]. Serological evidence of infection is especially found in severe cases of chronic obstructive pulmonary disease [10,19].…”

Section: Introductionmentioning

confidence: 99%

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The role of chlamydia in the pathogenesis of pulmonary emphysema

Theegarten¹,

Mogilevski²,

Anhenn³

et al. 2000

Virchows Archiv

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Chlamydia pneumoniae has been detected in atherosclerotic plaques by various means. Chlamydiae are able to cause persistent infections. Serologically elevated antibody titers are found in severe chronic obstructive pulmonary disease. In atherosclerosis and pulmonary emphysema, inflammatory reactions can be seen by means of light microscopy. Specimens from patients with obliterative arteriosclerosis undergoing thrombendarteriectomy and with advanced emphysema undergoing lung volume reduction surgery were examined using scanning (SEM) and transmission (TEM) electron microscopy, and using immunofluorescence with monoclonal antibodies and antiserum against chlamydiae. SEM shows spherical bodies (SBs) with a diameter from 0.3 microm to 0.6 microm on the surface of the alveoli and bronchioles, as well as in atherosclerotic plaques. In atherosclerosis and emphysema, SBs reveal a double membrane, adherence to collagen fibers, tissue destruction, as well as intracellular and interstitial localization in TEM. They show in parts a densely packed central structure. SBs are seen both in alpha-1-antitrypsin deficiency emphysema and smoker's emphysema. Using immunofluorescence microscopy, spots are seen in corresponding distributions to the SBs. Morphological findings are typical for aberrant chlamydiae seen in persistent infections. Chronic infection and bacterial colonization associated with progressive disease seems to be relevant not only in atherosclerosis but also in pulmonary emphysema.

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Section: Introductionmentioning

confidence: 99%

“…Cp is a well-known pathogen in acute and chronic respiratory infections [10]. Serological evidence of infection is especially found in severe cases of chronic obstructive pulmonary disease [10,19]. In these patients, emphysema is dominant [18].…”

Section: Introductionmentioning

confidence: 99%