Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?

Pietro, Marisa Di; Schiavoni, Giovanna; Sessa, Vincenzo; Pallotta, Francesco; Costanzo, Giovanna; Sessa, Rosa

doi:10.1007/s00198-012-2217-1

Cited by 18 publications

(19 citation statements)

References 22 publications

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“…They found chlamydial DNA in osteoporotic bone tissue but not in non-osteoporotic bone tissue [5]. In addition, they detected a significant association between the presence of C. pneumoniae DNA, both in bone tissue and in peripheral blood mononuclear cells of osteoporotic women, and an increase in the sRANKL/OPG ratio and circulating resorptive cytokines [5].…”

Section: Discussionmentioning

confidence: 95%

“…In addition, they detected a significant association between the presence of C. pneumoniae DNA, both in bone tissue and in peripheral blood mononuclear cells of osteoporotic women, and an increase in the sRANKL/OPG ratio and circulating resorptive cytokines [5]. Hence, Di Pietro et al [5] considered C. pneumoniae infection as a new risk factor for osteoporosisassociated bone loss.…”

Section: Discussionmentioning

confidence: 95%

“…Very recently, Di Pietro et al [5] evaluated 32 women with osteoporosis and 27 with osteoarthritis who underwent hip joint replacement surgery for femoral neck fracture to determine whether C. pneumoniae infection is a risk factor for osteoporosis-associated bone loss. They found chlamydial DNA in osteoporotic bone tissue but not in non-osteoporotic bone tissue [5].…”

Section: Discussionmentioning

confidence: 98%

“…Indeed, in vitro and in vivo studies have shown that infection with C. pneumoniae produces potentially inflammatory and bone resorptive cytokines and chemokines [3,4]. Very recently, it has been reported that chlamydial DNA was found in osteoporotic bone tissue [5].…”

Section: Introductionmentioning

confidence: 98%

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Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

et al. 2015

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

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Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

et al. 2015

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“…in the development of chronic sequelae since they can evade the host immune response and are more difficult to eradicate by antibiotics (2)(3)(4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

New Insights into Chlamydiae Persistence: An Energy Metabolism Strategy?

Pietro

Filardo

Santis

et al. 2013

Int J Immunopathol Pharmacol

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Chlamydiaceae is a family of obligate intracellular bacteria generally considered energy parasites. Several studies have suggested that Chlamydiae are capable of independently producing energy and, more importantly, several genes involved in the energy metabolism are up-regulated during the persistent state. Thus, it has been suggested that chlamydial persistence could be a complex and flexible metabolic strategy designed to favor a lengthy survival in the host cell by evading the immune response. In conclusion, more detailed studies on the shift in the chlamydial energy metabolism, from the active to the persistent form, may be helpful in future to determine whether chlamydial persistence observed in vitro does occur in vivo and whether chronic sequelae of chlamydial diseases may be related to the persistence.

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Lunate bone loss associated with Chlamydia pneumoniae infection

Rosa

Tosi

Caserta

et al. 2021

Trauma Case Reports

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Respiratory pathogens such as Chlamydia pneumoniae may activate osteoclast cells, thereby inducing bone resorption and joint inflammation. Herein is a case report of a young man with misdiagnosed persistent wrist pain without any major trauma. Investigation of the patient's medical history confirmed a recent systemic C. pneumoniae infection. Preoperative X-ray and magnetic resonance imaging (MRI) showed a substantial decrease in cancellous lunate bone compactness. A stepwise approach was undertaken considering the rapid onset of bone devascularisation and the clinical presentation. Wrist arthroscopy confirmed extensive joint inflammation associated with decreased osteochondral lunate solidity. Microbiological examination excluded joint infection. Histological analysis showed a diffuse inflammatory infiltration. Temporary mediocarpal K-wire stabilization and synovectomy were performed. Postoperative MRI confirmed lunate bone revascularization. At 6 and 12 months' follow-up the young man was pain-free and had good recovery of range of motion. In vitro and in vivo studies demonstrate that inflammatory conditions may promote osteoclast cell activity and induce bone resorption. Moreover, infection with C. pneumoniae could activate specific “osteoporotic” bone pathways. To the authors' knowledge, this is the first published case report of specific lunate bone loss induced by systemic C. pneumoniae infection. The authors proposed an etiologic explanation, and a stepwise approach was associated with good outcome.

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Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?

Abstract: The association between the presence of C. pneumoniae DNA, both in bone tissue and PBMCs, and the increase in sRANKL/OPG ratio as well as in IL-1β and IL-6 levels observed in osteoporotic patients suggests C. pneumoniae infection as a new risk factor for osteoporosis.

Cited by 18 publications

References 22 publications

Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

New Insights into Chlamydiae Persistence: An Energy Metabolism Strategy?

Lunate bone loss associated with Chlamydia pneumoniae infection

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