Chlamydia trachomatis infection and pregnancy outcome

Rl, Sweet; Landers, DV; Walker, C. H. M.; Schachter, Julius

doi:10.1016/0020-7292(88)90309-8

Cited by 121 publications

(16 citation statements)

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“…The relationship between genital colonization with U. urealyticum and pregnancy complications, such as preterm labor and delivery, is controversial (4)(5)(6)(28)(29)(30)(31). In this study, U. urealyticum was accurately identified by culturing vaginal secretions followed by PCR analysis.…”

Section: Discussionmentioning

confidence: 96%

Vaginal infection with Ureaplasma urealyticum accounts for preterm delivery via induction of inflammatory responses

Harada

Tanaka

Komori

et al. 2008

Microbiology and Immunology

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U. urealyticum, a member of the family Mycoplasmataceae, is often detected in the vagina of pregnant women. In this study, the possible association of ureaplasmal infection with preterm delivery was examined, as was the capacity of ureaplasmal LP to stimulate monocytes in vitro to produce proinflammatory cytokines relevant to preterm delivery. A hundred cases of normal delivery and 45 cases of preterm delivery were randomly selected. A mAb against U. urealyticum urease, that selectively and positively stained it in vaginal secretions of infected women but not in those of uninfected women, was generated. The preterm delivery group showed a significantly higher incidence of vaginal infection with this bacteria than the normal delivery group. Since the LP of Mycoplasma has potent biological activity, ureaplasmal LP was extracted. THP-1 cells, and human monocytic cells, produced IL-8, a potent proinflammatory cytokine associated with preterm delivery, and showed apoptotic cell death in response to the LP in vitro. These results suggest that U. urealyticum infection might play a causative role in preterm delivery via LP-induced IL-8 production and apoptosis.

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Section: Discussionmentioning

confidence: 96%

Vaginal infection with Ureaplasma urealyticum accounts for preterm delivery via induction of inflammatory responses

Harada

Tanaka

Komori

et al. 2008

Microbiology and Immunology

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“…105 Chlamydia is probably associated with preterm birth only in the presence of a maternal immune response, and most probably with a RR of about 2. 106 Syphilis and gonorrhoea are probably associated with preterm birth with a RR of about 2. 107 Vaginal group B streptococcus, U urealyticum, and M hominus colonisations are not associated with increased risk of preterm birth.…”

Section: Pregnancy Characteristicsmentioning

confidence: 99%

Preterm Birth 1: Epidemiology and Causes of Preterm Birth

Goldenberg

Culhane

Iams

et al. 2009

Obstetric Anesthesia Digest

493

725

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This paper is the fi rst in a three-part series on preterm birth, which is the leading cause of perinatal morbidity and mortality in developed countries. Infants are born preterm at less than 37 weeks' gestational age after: (1) spontaneous labour with intact membranes, (2) preterm premature rupture of the membranes (PPROM), and (3) labour induction or caesarean delivery for maternal or fetal indications. The frequency of preterm births is about 12-13% in the USA and 5-9% in many other developed countries; however, the rate of preterm birth has increased in many locations, predominantly because of increasing indicated preterm births and preterm delivery of artifi cially conceived multiple pregnancies. Common reasons for indicated preterm births include pre-eclampsia or eclampsia, and intrauterine growth restriction. Births that follow spontaneous preterm labour and PPROM-together called spontaneous preterm births-are regarded as a syndrome resulting from multiple causes, including infection or infl ammation, vascular disease, and uterine overdistension. Risk factors for spontaneous preterm births include a previous preterm birth, black race, periodontal disease, and low maternal body-mass index. A short cervical length and a raised cervical-vaginal fetal fi bronectin concentration are the strongest predictors of spontaneous preterm birth.

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“…Chlamydial infection has been associated with prematurity in some studies but not in others, with the majority of the studies showing no increased risk [118,127]. Sweet and coworkers [128], however, reported that women who had Chlamydia trachomatis infection and IgM antibodies were more likely to have a spontaneous preterm birth compared with women who have chlamydia infection and IgG, but not IgM, antibodies. In the Preterm Prediction Study [129], women tested for Chlamydia trachomatis at 24 weeks' gestation had about twice as many preterm births associated with the presence of this organism as did uninfected women; however, after adjusting for other risk factors, this association was no longer significant, contributing to the continuing uncertainty about whether chlamydia infection plays a causative role in preterm birth.…”

Section: Sexually Transmitted Diseases and Preterm Birthmentioning

confidence: 99%

Maternal Infection and Adverse Fetal and Neonatal Outcomes

Goldenberg

Culhane

Johnson

2005

Clinics in Perinatology

153

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Adverse pregnancy outcomes can follow direct placental, fetal, or neonatal infection, or preterm birth associated with vaginal, cervical, intrauterine, or even nonpelvic infections. These latter infections appear to be associated with the majority of very early preterm births, and may explain some of the long-term neurologic damage associated with preterm birth. Bacterial vaginosis and its associated intrauterine infections likely contribute far more to the overall burden of adverse pregnancy outcomes than the more classical perinatal infections such as rubella and syphilis.

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Chlamydia trachomatis infection and pregnancy outcome

Cited by 121 publications

References 0 publications

Vaginal infection with Ureaplasma urealyticum accounts for preterm delivery via induction of inflammatory responses

Vaginal infection with Ureaplasma urealyticum accounts for preterm delivery via induction of inflammatory responses

Preterm Birth 1: Epidemiology and Causes of Preterm Birth

Maternal Infection and Adverse Fetal and Neonatal Outcomes

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