Chlamydia trachomatis infection may increase the risk of preeclampsia

Haggerty, Catherine L.; Panum, Inge; Uldum, Søren A.; Bass, Debra C.; Olsen, Jørn; Darville, Toni; Eastman, Jamie M.; Simhan, Hyagriv N.; Roberts, James M.; Ness, Roberta B.

doi:10.1016/j.preghy.2012.09.002

Cited by 18 publications

(21 citation statements)

References 33 publications

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“…25 Our subset has similar characteristics compared to primiparous/singleton women in the DNBC. For example, in both groups most women had a maternal age between 26–30 (52.9% vs. 52.2%) and a high socio-occupational status (67.5% vs. 64.9%).…”

Section: Methodsmentioning

confidence: 83%

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

Taylor

Ness²,

Olsen

et al. 2015

Hypertension

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Leptin, an adipocyte-derived hormone, plays an important role in reproduction and angiogenesis. Studies examining leptin in preeclampsia are inconsistent, possibly due to small sample sizes and variability in sampling and outcome. We conducted a nested case-control study to examine associations between serum leptin (measured: 9–26 weeks gestation) and preeclampsia among 430 primiparous preeclamptic women and 316 primiparous normotensive controls from the Danish National Birth Cohort. Median [interquartile range] leptin concentrations were calculated. Associations between leptin and preeclampsia (blood pressure ≥ 140/90mmHg), term preeclampsia (preeclampsia and delivery ≥ 37 weeks gestation), or preterm (preeclampsia and delivery < 37 weeks gestation) preeclampsia were examined using generalized linear models adjusting for body mass index, gestational age at blood draw, maternal age, smoking, and socio-occupational status. As leptin is increased in obese women and the risk of preeclampsia increases with body mass index, we used the Sobel test to examine if leptin is a mediator of this relationship. After adjustments, leptin concentrations were significantly higher in women with preeclampsia [30.5(24.6) p=0.0117] and term preeclampsia [30.4(24.9) p=0.0228] compared to controls [20.9(28.3)]. There was no significant difference between preterm preeclampsia [30.6(23.4) p=0.2210] and controls. Leptin is a possible mediator of the association between body mass index and preeclampsia (p=0.0276). Leptin concentrations are higher in women with preeclampsia compared to normotensive controls and may mediate some of the relationship between body mass index and preeclampsia.

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Section: Methodsmentioning

confidence: 83%

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

Taylor

Ness²,

Olsen

et al. 2015

Hypertension

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“…This study was part of a previously completed nested case control study of 562 women with preeclampsia and 377 normotensive controls from the Danish National Birth Cohort (DNBC) [27]. In this study, both cases and controls were primiparous with singleton pregnancies, had no gestational hypertension and no history of hypertension.…”

Section: Methodsmentioning

confidence: 99%

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Taylor

Tang

Ness

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

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Objectives To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. Study Design Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9–26). Main Outcome Measures Preeclampsia was defined by blood pressure ≥ 140/90mmHg and proteinuria ≥3g/24h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; 1) biomarkers were dichotomized by the limit of detection (LOD): 2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking. Results IL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1–2.3) and term preeclampsia (ORadj 1.7, 95% CI 1.1–2.5) but not preterm preeclampsia. Detectable IL6 was significantly associated with term preeclampsia only (ORadj 1.5, 95% CI 1.1–2.2). Conclusion Mid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk.

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“…Some specific infections found to be associated with the development of pre-eclampsia include Chlamydia trachomatis ,16 Helicobacter pylori ,18 Chlamydia pneumoniae ,17 19 urinary tract infections,20 21 infection associated with periodontal disease,9 cytomegalovirus,10 and parasitic infections including Plasmodium spp and Toxoplasma gondii 10…”

Section: Discussionmentioning

confidence: 99%

Hsv Infection is Associated with Gestational Hypertension: Results from the Us National Inpatient Sample

Shi¹,

Wu²

2018

Journal of Investigative Medicine

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The purpose of this study was to determine if there is an association between maternal herpes simplex virus (HSV) infection and pre-eclampsia/eclampsia or gestational hypertension. The US Nationwide Inpatient Sample database was searched for women aged 15-44 years who delivered in a hospital between 2005 and 2014. The patients were categorized into those with and without HSV and pre-eclampsia/eclampsia and gestational hypertension were compared between the groups. The analytic sample size (n=8 264 076) was equivalent to a population-based sample size of 40 653 030 patients. After adjusting for significant variables including age, race, income, insurance status, diabetes mellitus (DM), gestational DM, obesity, and multiple gestations, multivariate regression analysis indicated that HSV was associated with a higher OR for gestational hypertension (adjusted OR 1.038; 95% CI 1.004 to 1.072). However, HSV was not associated with pre-eclampsia/eclampsia (OR 1.001; 95% CI 0.968 to 1.035) in univariate regression analysis. The results of the current study suggest that HSV infection is associated with gestational hypertension but not pre-eclampsia. Given the prevalence of HSV infection and its potential association with hypertensive disorders of pregnancy, further study of HSV and hypertension in pregnancy is warranted.

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Chlamydia trachomatis infection may increase the risk of preeclampsia

Cited by 18 publications

References 33 publications

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Hsv Infection is Associated with Gestational Hypertension: Results from the Us National Inpatient Sample

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