Chlamydial Infection and Its Role in Male Infertility

Samplaski, Mary K.; Domes, Trustin; Jarvi, Keith

doi:10.1155/2014/307950

Cited by 11 publications

(9 citation statements)

References 109 publications

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“…Because PCR diagnostic method is the most sensitive test for the detection of C. trachomatis and L. monocytogenes, in the current study the presence of these two bacteria in semen specimens of infertile men was assessed using this method. In a study conducted by Samplaski and colleagues on infertile men using the PCR assay at Toronto's Mount Sinai Hospital, the presence of C. trachomatis was estimated to be about 0.3% (34). The prevalence of C. trachomatis reported in the aforementioned studies is lower than the current study.…”

Section: Discussioncontrasting

confidence: 73%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

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Background: Infertility is one of the serious problems in gynecology and one of the most important issues of concern in couples. Meanwhile, a significant rise in infertility is recently reported in Iran due to the infections and harsh environmental conditions. Objectives: The current study aimed to detect Chlamydia trachomatis and Listeria monocytogenes in males with infertility using PCR, and to evaluate bacteriospermia effects of the studied bacteria on semen parameters. Methods: Semen specimens of 100 infertile men were collected. Then, each specimen was divided into two parts: the first part was tested by semen analysis according to the WHO guidelines and the second was tested using the PCR method. The PCR intended to identify C. trachomatis and L. monocytogenes. Results: Out of 100 semen samples, 20% were positive for C. trachomatis, 3% were positive for L. monocytogenes, and 3% were positive for both bacteria (coinfection). The leukocyte count was higher than the normal range (0 - 1 Mil/mL) in all semen specimens. The prevalence of C. trachomatis in azoospermic patients was significantly higher than that of nonazoospermic (P < 0.05). However, there was no significant difference between the two groups in terms of the detection of L. monocytogenes (P > 0.05). Detection of C. trachomatis and L. monocytogenes had no significant association with abnormal semen parameters in asymptomatic patients (P > 0.05). Conclusions: The results indicated that precise analysis of semen parameters and diagnosis of leukocytospermia in patients using the PCR can be considered as a rapid and accurate technique to detect bacteria such as C. trachomatis and L. monocytogenes in semen specimens. Therefore, the utilization of this technique in the screening programs for asymptomatic infertile couples can be helpful for early treatment.

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Section: Discussioncontrasting

confidence: 73%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

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“…There are significant variations in the prevalence of C. trachomatis infections in men with infertility ranging from 0% to 42.3%, depending on the methodology, type of sample and differences of infection rates in different populations. In a recently published Canadian study16 the prevalence of C. trachomatis infection in 5588 infertile men, was 0.3%. The author concluded that this low prevalence clearly demonstrates that a small proportion of male infertility is caused by C. trachomatis 17…”

Section: Discussionmentioning

confidence: 95%

Unusually low prevalence ofMycoplasma genitaliumin urine samples from infertile men and healthy controls: a prevalence study

et al. 2014

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ObjectiveTo detect Mycoplasma genitalium in urine samples of infertile men and men without any signs of infection in order to investigate whether M. genitalium and other genital mycoplasmas (Mycoplasma hominis and Ureaplasma spp) are found more often in urine samples of infertile men than in asymptomatic controls and to determine resistance to macrolides.MethodsThe study included first void urine samples taken from 145 infertile men and 49 men with no symptoms of urethritis. M. genitalium, Chlamydia trachomatis and Neisseria gonorrhoeae were detected by commercial PCR. Trichomonas vaginalis was detected by microscopy and culture. M. hominis and Ureaplasma spp were detected by culture. M. genitalium was detected by in-house conventional and real-time PCR.ResultsTwo M. genitalium positive samples were found among samples obtained from infertile men. All asymptomatic men were M. genitalium negative. Macrolide resistance was not found in either of the two positive samples.ConclusionsIn comparison with reported data, an unusually low prevalence of M. genitalium was found in infertile men. The reasons for this unexpected result are not known; possibly, local demographic and social characteristics of the population influenced the result. Further studies to investigate M. genitalium in infertile and other groups of patients are needed.

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“…On the other hand, in some literature it has been reported that Chlamydia trachomatis affects semen quality. These contradictory results could be due to the different methodologies and techniques used, which can be difficult to compare [36,37].…”

Section: Chlamydia Trachomatismentioning

confidence: 99%

Decrease in Sperm Quality due to Infection of Human Papilloma Virus and Chlamydia trachomatis

Colín-Ferreyra¹,

Domínguez-García²,

Flores-Merino³

2016

Genital Infections and Infertility

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Male infertility can have different causes, one of which may be the presence of etiologic agents that cause sexually transmitted infections. Among the most important sexually transmitted infections are human papillomavirus and Chlamydia trachomatis, which are associated with infertility in females -whether they cause infertility in men is controversial. The purpose of the chapter is to review the effect of these two pathogens on male fertility, the evidence suggests that the most important infertility effect is linked to the condition of the sperm. However, it is noteworthy that there are few studies with respect to infertility in regard to both pathogens, so it is important to further research this to elucidate the mechanisms by which these pathogens act on male infertility.

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Chlamydial Infection and Its Role in Male Infertility

Cited by 11 publications

References 109 publications

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Unusually low prevalence ofMycoplasma genitaliumin urine samples from infertile men and healthy controls: a prevalence study

Decrease in Sperm Quality due to Infection of Human Papilloma Virus and Chlamydia trachomatis

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