Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Ibrahim, Ibrahim A.; Shalaby, Abeir A.; Elaziz, Raghda T Abd; Bahr, Hoda I.

doi:10.1007/s11356-021-13411-w

Cited by 20 publications

(12 citation statements)

References 97 publications

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“…Furthermore, Huang et al [ 149 ] demonstrated that PbAc induced a dose-dependent reduction in AR expression in the spermatogenic cells, Sertoli cells, and Leydig cells. Given this, Pb is a known endocrine disruptor with estrogenic properties, and it may be responsible for antagonizing AR expression in male Wistar rats [ 42 , 150 , 151 ]. The decrease in testicular AR expression observed in PbAc-exposed rats may also be explained by a reduction in serum testosterone levels [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al2O3NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al2O3NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al2O3NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al2O3NPs and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al2O3NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al2O3NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al2O3NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al2O3NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system.

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Section: Discussionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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“…Phycocyanin can scavenge loose radicals along with alkoxyl, hydroxyl, and peroxyl radicals. It additionally reduces nitrite manufacturing and inhibits the expression of inducible nitric oxide synthase (iNOS), as severa research have shown (Ibrahim et al,2021, Roy and Pabbi,2022,Li et al,2022.…”

Section: 85±015bmentioning

confidence: 99%

Preventive role of spirulina on the some biomarkers in heart aging induced by D- galactose on the male rabbits

Alameri

Albazi

Al-Aameli

2022

ijhs

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The aim of this study is to investigate the preventive role of food supplementation with Spirulina powder in the heart aging. Twenty male rabbits randomly and equally divided into four groups, normal as control group GI, animals received 150 mg/kg BW S/C daily of D-galactos as GII, animals were received 500mg/kg BW orally of Spirulina as GIII while GIV group was recived 150 mg/kg BW daily S/C administration of D-galactos with 500mg/kg BW orally of Spirulina for four weeks. The results of the study showed a significant decrease in Cardiac troponin I and Peroxynitrate with a significant increase in Nitric oxide and Glutathione in group received Spirulina compared with aging group GII. Conclusion, our result indicate the feed supplement of Spirulina powder caused preventive role against heart aging.

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“…Recently, it was highlighted that C. vulgaris or S. platensis can have positive effects on testicular dysfunction provoked by lead acetate due to their antioxidant activity, immunomodulatory ability, and anti-apoptotic activity [182].…”

Section: Microalgae and Algaementioning

confidence: 99%

Natural Products as Protective Agents for Male Fertility

Martins

Silva

Duarte

et al. 2021

BioChem

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The male reproductive system is highly susceptible to noxious influences, such as oxidative stress, inflammation, drugs, and even diseases that can induce germ cell damage and alterations in spermatogenesis. All of these factors, which are caused by actions at the testicular level and/or at the excurrent ducts and accessory glands, significantly affect sperm parameters and male fertility. For this reason, it is of major importance to investigate possible ways to protect the male reproductive system since males are exposed to these toxic factors constantly. For centuries, natural products have been used by humans in folk medicine as therapeutic agents, and because of their beneficial properties for human health, plenty of them have been introduced to the pharmaceutical market as supplementary therapies. The present review aims to compile available information regarding different natural exogenous factors that demonstrate potential useful activity in the male reproductive system. The studies presented here reopen the perspective of using natural products as protective agents and eventually as new supplementary therapeutic options for the recovery of hampered spermatogenesis and/or male infertility.

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Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Cited by 20 publications

References 97 publications

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Preventive role of spirulina on the some biomarkers in heart aging induced by D- galactose on the male rabbits

Natural Products as Protective Agents for Male Fertility

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