Chlorhexidine–thymol varnish as an adjunct to scaling and root planing: A clinical observation

Anand, Vishal; Govila, Vivek; Gulati, Minkle; Anand, Bhargavi; Jhingaran, Rajesh; Rastogi, Pavitra

doi:10.1016/j.jobcr.2012.05.006

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Although in patients in group I we noted a reduction in the inflammatory phenomena in the periodontal tissue, we observed no significant changes in the analysis of subgingival plaque samples compared to T0. The use of some antimicrobial agents applied locally to the periodontal pockets after SRP has many benefits in the treatment of periodontal disease [24][25][26]. The data presented in table 2 demonstrate that the topical application of an antiseptic as an adjunct to SRP resulted in reducing the number of samples tested positive for each of the 5 periodontal bacteria: 8 for T. denticola, and 6 for P. intermedia.…”

Section: Resultsmentioning

confidence: 99%

The Use of Polymerase Chain Reaction (PCR) for Indentifying Periodontopathogenic Bacteria - therapeutic Implications in Periodontal Disease

Lazăr¹,

Bică²,

Martha³

et al. 2017

Rev. Chim.

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Polymerase chain reaction (PCR) shows a high specificity and allows us to identify pathogenic periodontal bacteria. We chose 45 patients wich were divided into three groups with various types of treatment: (I) - SRP; (II) - SRP, followed by topical application of antiseptics (SRP + local); (III) - SRP followed by systemic administration of antimicrobial agents (SRP + systemic). We collected samples from the initial time (TO) and one month after the treatment (T1) for each patient. For the microbiological assessment of periodontal therapy, we analyzed 90 subgingival plaque samples using PCR technique which provides qualitative data on five periodontopathogenic bacteria species: A. actinomycetemcomitans, P.gingivalis, P.intermedia, T.forsythia, and T.denticola. The treatment was followed by a qualitative change of the bacteria detected previously in a different ratio depending on the treatment. We found the inefficiency of mechanical treatment regarding the reduction of periodontal bacteria in patients belonging to group I, an improvement in the results of group II, while the treatment in group III proved to be the most effective . In patients detected A.a+ and/ or P.g+ a systemic antibiotic treatment is required because these periodontal bacteria penetrate the tissue and mucosal surfaces of the oral cavity.

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Section: Resultsmentioning

confidence: 99%

The Use of Polymerase Chain Reaction (PCR) for Indentifying Periodontopathogenic Bacteria - therapeutic Implications in Periodontal Disease

Lazăr¹,

Bică²,

Martha³

et al. 2017

Rev. Chim.

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“…11 However, besides proven efficacy in preventing plaque deposition and gingivitis, chlorhexidine-containing products for dental care have been associated with toothsurface discoloration as an apparent side effect. 12,13 An elevated number of chlorhexidine-based preparations for periodontal therapy are available in the market in a variety of formulations including dentifrices (0.4%); mouthwashes in either alcoholbased (ethanol) or non-alcoholic formulations; gelsn 14 thymol-containing varnishes, 15 chewing gums; and sprays. These preparations may appear in the form of gels, mouthwashes and dentifrices that can be selfapplied with or without supervision or administered by a dental healthcare professional.…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact and Cosmetic Acceptability of Chlorhexidineenriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study

Magaz¹,

Llovera²,

Martí³

et al. 2018

The Journal of Contemporary Dental Practice

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Aims: Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed to evaluate the efficacy of two different pharmaceutical forms [toothpaste (TP) and mouthwash (MW)] of a new product containing chlorhexidine, dexpanthenol, allantoin and bioadhesive excipient (CDAB) (Bexident ® Gums Coadjuvant Treatment) on volunteers with PD. Their preferences, acceptability and cosmetic properties, as well as tooth discoloration, were also assessed. Materials and methods:Total 60 subjects showing mildmoderate symptoms of gingivitis were randomly assigned to two different groups: one receiving TP (n = 30) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS).Results: All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP)/36.7% (MW)] and from mild to negative [increase = 56.7% (TP)/50.0% (MW)]. After treatment, all subjects reported to have healthier and/or less bleeding teeth (TP 9.0/9.4; MW 8.0/8.2) and would recommend the product (TP:100%/MW:96.6%) with no specific preference regarding its presentation. No change of teeth color was observed. Conclusion:Subjects with PD who received oral care with a new formulation of either chlorhexidine-containing TP or MW for 21 days, reported a significant improvement of their symptoms and resolution of the gingivitis with no associated tooth discoloration. Patients did not show a specific preference for any of the pharmaceutical presentations.Clinical significance: This new formulation of a chlorhexidinecontaining product in both TP and MW forms resulted effective for PD treatment and well accepted by the patients.

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The potential role of plant secondary metabolites on antifungal and immunomodulatory effect

Zhou

Zeng

Huang

et al. 2023

Appl Microbiol Biotechnol

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With the widespread use of antibiotic drugs worldwide and the global increase in the number of immunodeficient patients, fungal infections have become a serious threat to global public health security. Moreover, the evolution of fungal resistance to existing antifungal drugs is on the rise. To address these issues, the development of new antifungal drugs or fungal inhibitors needs to be targeted urgently. Plant secondary metabolites are characterized by a wide variety of chemical structures, low price, high availability, high antimicrobial activity, and few side effects. Therefore, plant secondary metabolites may be important resources for the identification and development of novel antifungal drugs. However, there are few studies to summarize those contents. In this review, the antifungal modes of action of plant secondary metabolites toward different types of fungi and fungal infections are covered, as well as highlighting immunomodulatory effects on the human body. This review of the literature should lay the foundation for research into new antifungal drugs and the discovery of new targets. Key points • Immunocompromised patients who are infected the drug-resistant fungi are increasing. • Plant secondary metabolites toward various fungal targets are covered. • Plant secondary metabolites with immunomodulatory effect are verified in vivo.

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Chlorhexidine–thymol varnish as an adjunct to scaling and root planing: A clinical observation

Abstract: Subjects with chronic periodontitis significantly benefit from scaling and root planing when used with an adjunct, chlorhexidine-thymol varnish (Cervitec Plus(®)).

Cited by 9 publications

References 14 publications

The Use of Polymerase Chain Reaction (PCR) for Indentifying Periodontopathogenic Bacteria - therapeutic Implications in Periodontal Disease

The Use of Polymerase Chain Reaction (PCR) for Indentifying Periodontopathogenic Bacteria - therapeutic Implications in Periodontal Disease

Clinical Impact and Cosmetic Acceptability of Chlorhexidineenriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study

The potential role of plant secondary metabolites on antifungal and immunomodulatory effect

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