Chlorhexidine varnishes: a review

Matthijs, S.; Adriaens, Patrick A.

doi:10.1034/j.1600-051x.2002.290101.x

Cited by 99 publications

(103 citation statements)

References 56 publications

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“…With regard to S. mutans levels, the largest reduction was also observed in group G2 (CHX + XYL) (91.3%), whereas group G3 (CHX) had 85.9%, a value close to that from G1 (XYL) (91.3%). These results support other previous studies 3,26,28 which showed that individuals using chlorhexidine had the best results regarding biofilm reduction compared to those using either fluoride or only xylitol (G4 and G1, respectively).…”

Section: Discussionsupporting

confidence: 92%

“…3,4,26,29 In our study, we observed that in those groups where chlorhexidine was one of the agents (G2 and G3), the levels of S. mutans continued to decrease even during the three month interval between the second and sixth month evaluations. This finding confirms its substantivity.…”

Section: Discussionmentioning

confidence: 48%

“…With regard to the amount of chlorhexidine in the varnish, different concentrations can be used, although 1% chlorhexidine yields better results according to the literature. 3,26,[29][30][31] The varnish vehicle was also justified due to the recommendation of not using gels or mouthwashes for young children.…”

Section: Discussionmentioning

confidence: 99%

“…1 The biofilm produced by this pathogen accounts for S. mutans adhesion, and is therefore considered to be cariogenic as well. 2 Chlorhexidine (CHX) 3,4 and xylitol (XYL) 5 have been used as strategies to prevent and reduce carious lesions. 6,7 Aims To assess the effect of combining 1% chlorhexidine varnish (CHX) with xylitol chewing gum (XYL) on Streptococcus mutans and biofilm levels in 6-8-year-old children.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial effects of the combination of chlorhexidine and xylitol

et al. 2010

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial effects of the combination of chlorhexidine and xylitol

et al. 2010

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“…However, this side effect can be eliminated with the use of local CHX varnish application 29 . In the selected articles, different concentrations of CHX varnishes were used.…”

Section: Discussionmentioning

confidence: 99%

Effects of chlorhexidine varnish on caries during orthodontic treatment: a systematic review and meta-analysis

et al. 2016

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This study aimed to perform a systematic review and meta-analysis to evaluate the effectiveness of chlorhexidine varnish on the reduction of caries incidence during fixed orthodontic treatment. The literature searches involved The Cochrane Library, Medline, Scopus, OpenSigle databases and manual searches. The search on OpenSigle did not produce any additional articles. Clinical studies conducted in patients with orthodontic fixed appliances that used professional application of chlorhexidine varnish were included. The effect-size was calculated and a metaanalysis was performed. From 182 abstracts, a total of six articles fulfilled the inclusion criteria. After reading the full articles, one was excluded because of lack of a control group. Three articles were used for continuous data analysis, and two articles were used for the dichotomous data analysis. The pooled meta-analysis with continuous data demonstrated chlorhexidine varnish effectiveness on caries reduction (p = 0.003), with a mean difference and confidence interval of −1.49 [−2.47, −0.51]. On the basis of the pooled meta-analysis of continuous data, we were able to conclude that professional application of chlorhexidine varnish is effective in caries incidence reduction during fixed orthodontic treatment.

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