Chlorinated Biphenyls in Fish, Mussels and Birds from the River Rhine and the Netherlands Coastal Area

Koeman, J.H.; Brauw, M.C. ten Noever de; Vos, R.H. de

doi:10.1038/2211126a0

Cited by 290 publications

(52 citation statements)

References 7 publications

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“…A significant difference in toxicity between 3 samples of commercial PCB preparations was found in a previous study (Vos and Koeman,I970), despite the marked resemblance of the gas chromatograms and the mass spectra (Koeman et al, 1969). One hundred per cent mortality, centrolobular liver necrosis, and SC and abdominal edema were found only in chicks fed the samples of Clophen A60 and Phenoclor DP6.…”

mentioning

confidence: 61%

Dermal toxicity studies of technical polychlorinated biphenyls and fractions thereof in rabbits

Vos

Beems

1971

Toxicology and Applied Pharmacology

115

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A significant difference in toxicity between 3 polychlorinated biphenyl (PCB) preparations was found in a prior study: Clophen A 60 and Phenoclor DP6 showing the highest, Aroclor 1260 the lowest, toxicity . A subsequent study revealed the presence of tetra-and pentachlorodibenzofuran in Phenoclor and Clophen . In the present study, application of 118 mg of the 3 PCB's (5 times per wk, for 38 days) on the back skin of rabbits also resulted in differences in toxicity.PCB-induced skin lesions were hyperplasia and hyperkeratosis of the epidermal and follicular epithelium. Histopathology of the liver included centrolobular degeneration, centrolobular liver cell atrophy, focal necrosis, and cytoplasmic hyalin degeneration. Definite hyperplasia and hyperkeratosis of the follicular epithelium of the ear skin were seen after the topical application of fractions of Phenoclor and Clophen eluted from chromatographic columns with 25 ",/, diethylether in hexane. The fraction from Aroclor caused a minimal hyperplasia and hyperkeratosis of the follicular epithelium. PCB-induced kidney lesions were hydropic degeneration of the convoluted tubules and tubular dilatation with the presence of casts. This dilatation was demonstrated also by a significantly increased relative percentage of the diameter which corresponds to the space of Bowman. Moreover, thymus atrophy and lymphopenia were found. Fecal coproporphyrin and protoporphyrin excretion was increased.

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confidence: 61%

Dermal toxicity studies of technical polychlorinated biphenyls and fractions thereof in rabbits

Vos

Beems

1971

Toxicology and Applied Pharmacology

115

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“…Polychlorinated biphenyls (PCBs) have been found in fish and wildlife from many parts of the world at levels which may adversely affect aquatic organisms and interfere with pesticide residue analyses (1,2,3,4). The environmental occurrence, uses, and present toxicological aspects of PCBs were recently reviewed by Peakall and Lincer (5), Gustaffson (6), and Risebrough (7).…”

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confidence: 99%

Toxicities of PCBs to Fish and Environmental Residues

Stalling¹,

Mayer²

1972

Environmental Health Perspectives

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“…Effects of the latter are liver damage (7), chloracne (7,8) and edema formation (9 toxicity of three commercial PCB samples (containing 60% chlorine on the average): Phenoclor DP6 (sample I), Clophen A60 (sample II) and Aroclor 1260 (sample III). These three mixtures showed a marked resemblance in their gas chromatograms and mass spectra (10). In this comparative feeding test in one-day-old chicks (11), it was found that 100% mortality, subcutaneous and abdominal edema, and centrolobular liver necrosis occured in only two groups (fed the samples I and II).…”

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confidence: 92%

Toxicology of PCBs for Mammals and for Birds

Vos¹

1972

Environmental Health Perspectives

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IntroductonIn the early days of its use, little work was done on the toxicology of the PCBs, and this was only in relation to the risks of occupational exposure. As will be shown many more studies were made as soon as it appeared that the extremely stable PCB's became a threat to the environment and its wildlife, and accidents occurred of acute poisoning in man and animals. These studies have been made with material with different contents of chlorine, from different manufacture, and-as we can now say in retrospect-with different and unknown contents of toxic impurities. For this reason the toxicological information of PCB's is difficult to summarize, but since the character of some important impurities has recently been elucidated, it is well to discuss these first in order to be able to consider their contribution to the overall toxicity of the different preparations studied.These studies were started because of the analogy between the effects of the PCBs (1-6) and some toxic effects associated with toxic factors in crude chlorophenols and in "toxic fat". Effects of the latter are liver damage (7), chloracne (7,8) and edema formation (9).

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Chlorinated Biphenyls in Fish, Mussels and Birds from the River Rhine and the Netherlands Coastal Area

Cited by 290 publications

References 7 publications

Dermal toxicity studies of technical polychlorinated biphenyls and fractions thereof in rabbits

Dermal toxicity studies of technical polychlorinated biphenyls and fractions thereof in rabbits

Toxicities of PCBs to Fish and Environmental Residues

Toxicology of PCBs for Mammals and for Birds

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