Chlorine Dioxide is a Better Disinfectant than Sodium Hypochlorite against Multi-Drug Resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt;, &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;, and &lt;i&gt;Acinetobacter baumannii&lt;/i&gt;

Hinenoya, Atsushi; Awasthi, Sharda Prasad; Yasuda, Noritomo; Shima, Ayaka; Morino, Hirofumi; Koizumi, Tomoko; Fukuda, Takashi; Miura, Takanori; Shibata, Takashi; Yamasaki, Shinji

doi:10.7883/yoken.jjid.2014.294

Cited by 28 publications

(21 citation statements)

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“…However, a ClO 2 solution of 10 mg/L drastically reduced the number of MDR-P. aeruginosa and MDR-A. baumannii bacteria within 60 s under conditions of a mixture containing a high concentration of bovine serum albumin and sheep erythrocytes [8]. Furthermore, the effect of inactivation by a ClO 2 solution of 10 mg/L against drug-sensitive P. aeruginosa (1.4 log 10 reductions, within 15 s) was lower than that against MDR-P. aeruginosa (3.6 log 10 reductions, within 15 s).…”

Section: Discussionmentioning

confidence: 97%

Effect of extremely low-concentration gaseous chlorine dioxide against surface Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii in wet conditions on glass dishes

et al. 2020

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Objective: Healthcare-associated infections due to Gram-negative bacteria (GNB) are a major cause of mortality and morbidity throughout the world. The purpose of the research described here was to evaluate the possibility of using an extremely low-concentration gaseous chlorine dioxide (ClO 2 , 0.01 ppmv, 0.028 mg/m 3) as a technique to reduce the risk of environmental infection by GNB. In this study we set up an exposure chamber (1 m 3) and used three types of GNB, namely Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii. Results: The extremely low-concentration gaseous ClO 2 inactivated E. coli (> 2 log 10 reductions, within 2 h), P. aeruginosa (> 4 log 10 reductions, within 2 h) and A. baumannii (> 2 log 10 reductions, within 3 h) in wet conditions on glass dishes. Treatment of moist environments with extremely low-concentration gaseous ClO 2 may help to reduce the risk of environmental infection by GNB without harmful effects.

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Section: Discussionmentioning

confidence: 97%

Effect of extremely low-concentration gaseous chlorine dioxide against surface Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii in wet conditions on glass dishes

et al. 2020

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“…Supporting this, the addition of 100 ppm ClO 2 to a suspension of MRSA was shown to reduce the number of CFUs from 10 7 to below the detection limit after a 15 s incubation period. This compares favourably to sodium hypochlorite, where 100 ppm of this agent had no effect on the number of MRSA CFUs after a 120 s incubation period; however, the strength of the disinfectant solutions used in this study were not reflective of that used in the hospital environment 11. The effectiveness of ClO 2 against C. difficile spores in a laboratory setting has also been demonstrated 13.…”

Section: Introductionmentioning

confidence: 59%

Reduction in the incidence of hospital-acquired MRSA following the introduction of a chlorine dioxide 275 ppm based disinfecting agent in a district general hospital

et al. 2015

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BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile are major nosocomial pathogens whose control relies on effective antimicrobial stewardship and infection control practices. This study evaluates the impact of a chlorine dioxide-based disinfectant (275 ppm) on the incidence of hospital-acquired (HA) MRSA and HA-Clostridium difficile infection (CDI) in a district general hospital.MethodsThis study was carried out from November 2009 to September 2013. From November 2009 to October 2011 sodium dichloroisocyanurate was used for routine environmental disinfection. In November 2011, this was changed to a chlorine dioxide 275 ppm based disinfectant. This product was introduced into the hospital in a phased manner with intensive training on its use provided to all nursing, nursing auxiliary and hotel services staff. The effect of this change on the incidence of HA-MRSA and HA-CDI was assessed using segmented regression analysis of interrupted time series. In addition, the potential cost savings as a result of this intervention were assessed.ResultsThe HA-MRSA trend from November 2009 to October 2011 significantly increased (p=0.006). Following the introduction of the chlorine dioxide-based disinfectant there was significant decrease in the HA-MRSA trend, with the monthly incidence being reduced by 0.003 cases/100 bed days (p=0.001), equating to an average of four cases per month after 12 months of use This resulted in an annual potential cost saving of £276 000. No significant effect on the incidence of HA-CDI was observed (coefficient −0.03; p=0.873).ConclusionThis study highlights the importance of effective environmental inanimate surface decontamination in controlling the spread of MRSA and the potential cost savings that can be achieved through decreasing HA-MRSA rates.

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“…Chlorine dioxide is more suitable for soil disinfection than NaClO. 43 It evaporates rapidly from an aqueous solution as a gas and then permeates the soil to contact and kill bacteria. However, HOCl and other liquid disinfectants have less permeability in the soil.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of antibiotic-resistant bacteria by chlorine dioxide in soil and shifts in community composition

Xu²

2019

RSC Adv.

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Chlorine Dioxide is a Better Disinfectant than Sodium Hypochlorite against Multi-Drug Resistant <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i>

Cited by 28 publications

References 12 publications

Effect of extremely low-concentration gaseous chlorine dioxide against surface Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii in wet conditions on glass dishes

Effect of extremely low-concentration gaseous chlorine dioxide against surface Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii in wet conditions on glass dishes

Reduction in the incidence of hospital-acquired MRSA following the introduction of a chlorine dioxide 275 ppm based disinfecting agent in a district general hospital

Inactivation of antibiotic-resistant bacteria by chlorine dioxide in soil and shifts in community composition

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