Chloroformylation of α‐Pyrrolones

Substituted E-3-(3-Indolylmethylene)-1,3-dihydroindol-2-ones with Antitumor Activity. In Depth Study of the Effect on Growth of Breast Cancer Cells

“…The oxindoles 1d , 1j , 1o , the aldehyde 2h and the isatin 3 are commercially available. The following compounds were prepared according to the literature: 1a , 1b , 1c , 1e , 1f , 1g 1i , 1k , 1l , 1m , 1n , 2a , 2b , 2c , 2f , 2g , and 35 …”

“…General Procedure for the Synthesis ofCompounds 5,[7][8][9][10][12][13][14][15][16][17][18][19][20][21][22][23][27][28][29][30][31][32][33][34]and 36. The appropriate 2-indolinone 1 (10 mmol) was dissolved in methanol (100 mL) and treated with the equivalent of the appropriate indole-3-carbaldehyde 2 and piperidine (1 mL).…”

Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells

“…The oxindoles 1c and 1e are commercially available. The following compounds were prepared according to the literature: 1a [9], 1b [10], 1d [11], 1f [12], 1g [13], 1h [14], 1i [15], 1j [16], 2a [17], 2c [4], 2d [6], 2e [18], 2f, hei [19], 2m [20].…”

Imidoyl Halides

“…Thus, formylation of pyrroles (112,220,240,246), tetrahydroquinolines e 38 ), indoles e SO ,306), naphthostyryl e 79), carbazoles (82,84,238), benzazepines e 29 ), thiophenes (86,180, 181,236,301,302), 2,2'-bithenyl e 1 ), thionaphthenes e 79), thiazines (84), dithiadienes e 25 ), sydnones e S ), and other heterocycles e 30 ) are reported. In the pyrrole series ketones are sometimes obtained in good yield e 12).…”